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TerminatedNCT00704782Updated Dec 10, 2015

Study of Combination Therapy With Dimebon and Donepezil (Aricept) in Patients With Alzheimer's Disease

A Phase 2 interventional study of dimebon in Alzheimer's Disease, sponsored by Medivation, Inc.. Terminated at 4 sites in United States. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2015-12-10.

Sponsored by Medivation, Inc. · Phase 2, Interventional, and Treatment

Why this study was terminated
The study was halted after a Phase 3 study of dimebon failed to show efficacy.
Phase
Phase 2
Study type
Interventional
Enrollment
50
Allocation
Not applicable
Ages
50 Years and older
Sex
All
01

Study summary

The purpose of this study is to assess the safety and efficacy of Dimebon in combination with donepezil (Aricept) in the treatment of Alzheimer's disease.

02

Conditions studied

  • Alzheimer's Disease

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03

In context

Alzheimer Disease

3,678 studies on the registry are indexed under Alzheimer Disease; 872 are open to participants now.

This study's enrollment of 50 is below the median of 70 across 2,808 interventional studies indexed under Alzheimer Disease.

Browse Alzheimer Disease studies →

Lead sponsor

Medivation, Inc. is the lead sponsor of 14 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Alzheimer's disease
  • On donepezil (Aricept)
  • Caregiver who cares for the patient at least 5 days per week

Exclusion criteria

Exclusion Criteria:

  • Unstable medical illnesses or significant hepatic or renal disease
  • Other primary psychiatric or neurological disorders
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
50 participants (actual)

Study arms

  • Experimental
    Dimebon

    20 mg by mouth 3 times a day

    Drug: dimebon

Interventions

  • Drugdimebon
06

What researchers measure

Primary outcomes

  1. To assess the safety of Dimebon in combination with donepezil (Aricept)

    Time frame: week 6, 9, 12, 26 and every 13 weeks thereafter until study discontinuation

07

Study locations

4 sites
  • Xenoscience, Inc.
    Phoenix, Arizona 85004, United States
  • Banner Alzheimer's Institute
    Phoenix, Arizona 85006, United States
  • Barrow Neurological Institute
    Phoenix, Arizona 85013, United States
  • Sun Health Research Institute
    Sun City, Arizona 85351, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 10, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00704782
Lead sponsor
Medivation, Inc.
Responsible party
Sponsor
First posted
Jun 25, 2008
Start date
Apr 2008
Primary completion
Aug 2010
Completion
Aug 2010
Last update
Dec 10, 2015
View the source record on ClinicalTrials.gov ↗

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This study is terminated, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.

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