Ottawa Hospital Research Institute: Breast Neoplasms trials

The registry lists 37 Breast Neoplasms studies with Ottawa Hospital Research Institute as lead sponsor. 4 are open to participants now and 6 have results posted.

Phase 2 7Phase 3 1Phase 4 18No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic Breast and Prostate CancersRecruitingNCT07252726Phase 4
• PD-1 +/- IL-4 Inhibition in ER+ Breast CancerNot yet recruitingNCT05967884Phase 2
• Evaluating Omission of Granulocyte Colony-stimulating Factors in Breast Cancer Patients Receiving Paclitaxel Portion of Dose-dense Adriamycin-cyclophosphamide and Paclitaxel ChemotherapyRecruitingNCT05753618Phase 4
• Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast CancerRecruitingNCT04921137Phase 4
• Evaluating the Dose Timing (Morning vs Evening) of Endocrine Therapy and Its Effects on Tolerability and ComplianceCompletedNCT04864405Phase 4Results posted
• Evaluating Whether Integration of Prognostic and Predictive Algorithms Into Routine Clinical Practice Effect Whether Oncologists Order Multigene Assays in Patients With Early Stage Breast CancerCompletedNCT04131933Results posted
• An Integrated Consent Model Study to Compare Two Standard of Care Schedules for Monitoring Cardiac Function in Patients Receiving Trastuzumab for Early Stage Breast CancerCompletedNCT02696707Phase 4Results posted
• Multicentre Study to Determine the Feasibility of Using an Integrated Consent Model to Compare Three Standard of Care Regimens for The Treatment of Triple-Negative Breast Cancer in the Neoadjuvant/Adjuvant Setting (REaCT-TNBC)TerminatedNCT02688803Phase 4Results posted
• Reducing Pain and Disability After Breast Cancer SurgeryCompletedNCT01089933Not applicableResults posted
• Post-operative Radiation With IMRT in the Management of Stage IIB-III Breast CancerCompletedNCT00508352Not applicableResults posted
• Evaluating an Endocrine Therapy Dose-frequency Escalation Strategy and Its Effects on Tolerability and ComplianceActive, not recruitingNCT05754528Phase 4
• A Randomized Trial Evaluating Personalized vs Guideline-based Well Follow-up Strategies for Patients With Early-stage Breast CancerCompletedNCT05365230Phase 4
• Utilizing MyChart to Assess the Effectiveness of Interventions for Vasomotor Symptoms: A Feasibility StudyCompletedNCT05222464Phase 4
• Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic TherapyActive, not recruitingNCT04928261Phase 4
• A Randomized, Multicenter Pragmatic Trial Comparing Bone Pain From a Single Dose of Pegfilgrastim to 5 Doses of Daily Filgrastim in Breast Cancer Patients Receiving Neoadjuvant/Adjuvant ChemotherapyCompletedNCT04781959Phase 4
• INVINCIBLE TRIAL: Intratumoral INT230-6 in Breast CancerStatus unknownNCT04781725Phase 2
• A Phase II Window of Opportunity Trial of PRMT5 Inhibitor, GSK3326595, in Early Stage Breast CancerCompletedNCT04676516Phase 2
• Comparing Continuation or De-escalation of Bone Modifying Agents (BMA) in Patients Treated for Over 2 Years for Bone Metastases From Either Breast or Castration-resistant Prostate CancerActive, not recruitingNCT04549207Phase 4
• Evaluating Optimal Timing of Endocrine Therapy and Radiation Therapy in Early-stage Breast Cancer (REaCT-RETT)CompletedNCT03948568Phase 4
• Mid-point Transverse Process to Pleura Block for Breast Cancer Surgery: A Randomized Controlled TrialStatus unknownNCT03713255Not applicable
• Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer (REaCT-ZOL)CompletedNCT03664687Phase 4
• Comparing Tapering Low Dose Dexamethasone to Other Standard of Care Therapies for TAPS in Breast Cancer PatientsCompletedNCT03348696Phase 4
• The EMPOwER Study Evaluating Multiparameter Gene Testing as a Predictor of Short Term Endocrine Therapy Response in Hormone Receptor Positive Breast CancersStatus unknownNCT03211572Phase 2
• Individualised Versus Standard Care for Breast Cancer Patients at High-risk for Chemotherapy-induced Nausea and Vomiting The ILIAD StudyCompletedNCT02861859Phase 3
• A Study to Compare Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Febrile NeutropeniaCompletedNCT02816164Phase 4
• 4-weekly Versus 12-weekly Administration of Bone-targeted Agents in Patients With Bone MetastasesCompletedNCT02721433Phase 4
• REaCT-vascular Access Her2 Negative Vascular Access Strategies for (Neo) Adjuvant Breast Cancer Treatment Without TrastuzumabCompletedNCT02688998Not applicable
• Randomized Trial Standard of Care Vascular Access Strategies for (Neo)Adjuvant Trastuzumab-based Breast Cancer Treatment.CompletedNCT02632435Not applicable
• Tumor Bed Dose Delivery Using A Breast Specific Radiosurgery Device, The Gammapod: (A Clinical Feasibility Study)Status unknownNCT02627313Not applicable
• A Multi Centre Study to Determine the Feasibility of Using an Integrated Consent Model to Compare Standard of Care Administration Schedules of G-CSF (Filgrastim) for Primary Prophylaxis of Chemotherapy-Induced Febrile Neutropenia in Early Stage Breast Cancer (React-G Study)CompletedNCT02428114
• A Phase 2 Randomized, Double-blind Trial Evaluating the Effects of Chloroquine in Breast CancerStatus unknownNCT02333890Phase 2
• FAST MRI Study in Breast Cancer SurvivorsCompletedNCT02244593Not applicable
• The Effect of an Inter-Disciplinary Program, Including MBSR, in Breast Cancer Survivors With Chronic Neuropathic PainCompletedNCT02125006Not applicable
• Feasibility Study of Presurgical Hormone Therapy (Anastrozole) in Breast Cancer PatientsCompletedNCT01972984Phase 2
• Effects of Vitamin D in Patients With Breast CancerCompletedNCT01948128Phase 2
• The ODYSSEY TRIAL Phase IV Trial Evaluating the Palliative Benefit of Pamidronate or Zoledronic Acid in Breast CancerCompletedNCT01907880Phase 4
• Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast CancerCompletedNCT00260975