National Institute of Allergy and Infectious Diseases (NIAID): Infections trials

The registry lists 308 Infections studies with National Institute of Allergy and Infectious Diseases (NIAID) as lead sponsor. 12 are open to participants now and 41 have results posted.

Phase 1 72Phase 2 88Phase 3 44Phase 4 5No phase 108(a study in two phases counts in both)

Studies

Page 3 of 4. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• The Safety and Effectiveness of a Two-Drug Combination in the Treatment of Patients With Hepatitis C Plus Advanced HIV InfectionsCompletedNCT00001035Phase 1
• The Treatment of Tuberculosis in HIV-Infected PatientsCompletedNCT00001033Phase 3
• A Study of Dideoxycytidine Plus Zidovudine (AZT) in HIV-Infected Children Who Have Taken AZTCompletedNCT00001032Phase 2
• The Safety and Effectiveness of Clarithromycin and Rifabutin Used Alone or in Combination to Prevent Mycobacterium Avium Complex (MAC) or Disseminated MAC Disease in HIV-Infected PatientsCompletedNCT00001030Phase 3
• The Safety and Effectiveness of Rifabutin, Combined With Clarithromycin or Azithromycin, in HIV-Infected PatientsCompletedNCT00001023Not applicable
• A Study of AL721 in HIV-Infected Patients With Swollen Lymph NodesCompletedNCT00001012Phase 1
• A Study of Zidovudine Plus Acyclovir in HIV-Infected PatientsCompletedNCT00001010Phase 1
• A Study of Zidovudine Plus Interleukin-2 in HIV-Infected Patients Who Have No Symptoms of Infection But Who Have Tender Lymph NodesCompletedNCT00001005Phase 1
• A Study of Foscarnet in the Treatment of HIV Infection in Patients Who Have Taken Zidovudine for a Long TimeCompletedNCT00001002Phase 1
• A Study of Zidovudine in HIV-Infected Patients With Liver DiseaseCompletedNCT00001001Not applicable
• A Study of Atvogen in Healthy Volunteers and HIV-Infected Patients Who Have No Symptoms of InfectionCompletedNCT00001000Not applicable
• The Safety and Effectiveness of Zidovudine (AZT) in the Treatment of HIV Infection in Patients With AIDS and Advanced ARCCompletedNCT00000999Phase 1
• A Study of Dideoxycytidine in HIV-Infected PatientsCompletedNCT00000997Not applicable
• A Study of AZT Plus Ganciclovir in Patients With AIDS and Cytomegalovirus (CMV) InfectionCompletedNCT00000995Not applicable
• A Study of AZT in HIV-Infected Patients With AIDS-Related Kaposi's SarcomaCompletedNCT00000994Phase 3
• A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDSCompletedNCT00000992Phase 1
• A Study of Three Drugs Plus Zidovudine in the Prevention of Infections in HIV-Infected PatientsCompletedNCT00000991Phase 3
• Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With AcyclovirCompletedNCT00000985Phase 3
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 (rCD4) in Infants and Children Infected With or at Risk for HIV InfectionCompletedNCT00000984Phase 1
• A Study of Azidothymidine in HIV-Infected ChildrenCompletedNCT00000982Phase 2
• The Safety and Effectiveness of FIAC in the Treatment of Cytomegalovirus (CMV) in Patients With AIDSCompletedNCT00000981Phase 2
• Comparison of ddI Versus Zidovudine in HIV-Infected PatientsCompletedNCT00000979Phase 2
• A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDSCompletedNCT00000975Phase 2
• A Study of Two Forms of Pentamidine in HIV-Infected Children Who May Have Pneumocystis Carinii PneumoniaCompletedNCT00000974Phase 1
• A Study of Pyrimethamine in the Treatment of Infection by a Certain Parasite in HIV-Positive PatientsCompletedNCT00000973Phase 1
• A Study of Foscarnet Plus Ganciclovir in the Treatment of Cytomegalovirus of the Eye in Patients With AIDS Who Have Already Been Treated With GanciclovirCompletedNCT00000970Phase 1
• A Study of Dideoxyinosine (ddI) in HIV-Infected Children Who Have Not Had Success With Zidovudine or Who Cannot Take ZidovudineCompletedNCT00000963Phase 2
• The Safety and Effectiveness of BI-RG-587 in HIV-Infected PatientsCompletedNCT00000962Phase 1
• The Safety and Effectiveness of Hyperimmune Anti-HIV Intravenous Immunoglobulin (HVIG) Plus Zidovudine in HIV-Infected InfantsTerminatedNCT00000961Phase 2
• Prophylaxis Against Tuberculosis (TB) in Patients With Human Immunodeficiency Virus (HIV) Infection and Suspected Latent Tuberculous InfectionCompletedNCT00000959Not applicable
• A Placebo-Controlled, Phase I, Pilot Clinical Trial to Evaluate the Safety and Immunogenicity of ENV 2-3, a Yeast-Derived Recombinant Envelope Protein of Human Immunodeficiency Virus-1, in Combination With MTP-PE/MF59 in Individuals With HIV Infection (Placebo Patients Receive MF59 Emulsion Only)CompletedNCT00000958Phase 1
• Two-Stage Tuberculin (PPD) Skin Testing in Individuals With Human Immunodeficiency Virus (HIV) InfectionCompletedNCT00000955Not applicable
• A Study to Evaluate the Effects of Giving Proleukin (rIL-2) to HIV-Positive Patients With CD4 Counts Greater Than 300 Cells/mm3CompletedNCT00000949Phase 3
• Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3CompletedNCT00000948Phase 2
• A Study to Evaluate the Effects of Azithromycin on MAC Disease Prevention in HIV-Positive PatientsCompletedNCT00000947Not applicable
• Five-Drug Anti-HIV Treatment Followed by Treatment Interruption in Patients Who Have Recently Been Infected With HIVCompletedNCT00000940Phase 2
• Effects of MAC Preventive Therapy on Disease-Causing Bacteria in HIV-Infected Patients: A Substudy of CPCRA 048CompletedNCT00000933
• A Study of Nonoxynol-9 (N-9) and HIV InfectionCompletedNCT00000926Phase 3
• The Effects of Prednisone on HIV Levels and the Immune SystemCompletedNCT00000921Phase 2
• A Study to Evaluate Various Combinations of Anti-HIV Medications to Treat Early HIV InfectionCompletedNCT00000919Not applicable
• A Study to Compare Two Anti-HIV Combination Therapies Each Containing Saquinavir in HIV-Positive ChildrenCompletedNCT00000913Phase 2
• A Study to Monitor Patients With Primary or Early HIV InfectionCompletedNCT00000911
• A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV TherapyCompletedNCT00000909Phase 2
• Safety and Effectiveness of Giving Indinavir Plus Stavudine Plus Lamivudine to HIV-Infected ChildrenCompletedNCT00000901Phase 1
• A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV InfectionCompletedNCT00000895Not applicable
• A Study to Evaluate the Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3CompletedNCT00000889Phase 2
• Long-Term Assessment for Metabolic, Cardiovascular and Neurologic Problems in HIV-Infected Patients With Increased CD4 Cells Counts Following Anti-HIV TherapyCompletedNCT00000883Not applicable
• A Study of Cidofovir in HIV-Infected Children With Cytomegalovirus (CMV) DiseaseWithdrawnNCT00000881Phase 1
• Controlled Clinical Trial of Antiviral Cytotoxic T Lymphocyte (CTL) Infusion Following Combination Antiretroviral Drug Therapy for Asymptomatic HIV-1 InfectionTerminatedNCT00000875Not applicable
• Treatment With Combinations of Several Antiviral Drugs in Infants and Young Children With HIV InfectionCompletedNCT00000872Phase 2
• A Phase II Study of Intermittent Recombinant Human Interleukin-2 (rhIL-2) by Intravenous or Subcutaneous Administration in Subjects With HIV Infection on Highly Active Antiretroviral Therapy (HAART) Compared to HAART AloneCompletedNCT00000870Phase 2
• The Safety and Effects of 1592U89 Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Infants and ChildrenCompletedNCT00000865Phase 1
• A Study of WR 6026 in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected PatientsCompletedNCT00000863Phase 2
• The Effects of Treatment for Mycobacterium Avium Complex (MAC) on the Cells of HIV-Infected PatientsCompletedNCT00000860
• Detection of Human Immunodeficiency Virus Type 1 (HIV-1) in Vaginocervical Secretions: Correlation With Clinical Status, Virologic and Immunologic Parameters, and the Presence of Other InfectionsCompletedNCT00000858
• A Phase I/II Pilot Treatment Study Of CSF Penetration And Response To Ganciclovir And Foscarnet In CMV Neurologic Disease.WithdrawnNCT00000856Phase 1
• A Pilot Study of Allogeneic Lymphocyte Transfer in HIV InfectionCompletedNCT00000852Not applicable
• The Safety and Effectiveness of Adefovir Dipivoxil in HIV-Infected ChildrenCompletedNCT00000843Phase 1
• A Study of Indinavir Sulfate Plus Zidovudine (AZT) Plus Lamivudine in HIV-Infected Patients Who Have Taken AZT for Six or More MonthsCompletedNCT00000841Phase 3
• A Phase I Study of Methotrexate for HIV InfectionCompletedNCT00000834Phase 1
• A Double-Blind Placebo-Controlled Trial of the Safety and Immunogenicity of a Seven Valent Pneumococcal Conjugate Vaccine in Presumed HIV-Infected InfantsCompletedNCT00000829Phase 1
• Effect of Fluconazole, Clarithromycin, and Rifabutin on the Pharmacokinetics of Sulfamethoxazole-Trimethoprim and Dapsone and Their Hydroxylamine MetabolitesCompletedNCT00000826Phase 1
• The Effects of Giving Interleukin-2 (IL-2) Plus Anti-HIV Therapy to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3CompletedNCT00000825Phase 2
• A Multicenter Phase II Double-Blind Exploratory Study to Evaluate Differences Among Various Zidovudine/Didanosine Regimens on Quantitative Measures of Viral Burden in Relatively Early HIV-1 InfectionCompletedNCT00000823Phase 2
• A Phase II Study of Low-Dose Interleukin-2 by Subcutaneous Injection in Combination With Antiretroviral Therapy Versus Antiretroviral Therapy Alone in Patients With HIV-1 Infection and at Least 3 Months Stable Antiretroviral TherapyCompletedNCT00000820Phase 2
• A Phase I, Placebo-Controlled, Dose-Escalation Study of the Safety, Tolerability, and Pharmacokinetics of Thalidomide in Subjects With HIV-1 InfectionCompletedNCT00000812Phase 1
• A Study to Compare Different Drugs Used to Prevent Serious Bacterial Infections in HIV-Positive ChildrenCompletedNCT00000811Phase 2
• A Pharmacokinetic and Tolerance Study of Oral Ganciclovir in HIV-Infected Children With Asymptomatic Cytomegalovirus Infection and Low CD4 Cell Counts or Quiescent Cytomegalovirus DiseaseCompletedNCT00000805Phase 1
• A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV InfectionCompletedNCT00000793Phase 2
• Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV InfectionCompletedNCT00000790Phase 2
• A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV InfectionCompletedNCT00000789Phase 2
• Pilot Study to Evaluate the Efficacy of Zidovudine in Preventing CD4+ Lymphocyte Decline in Patients With Primary HIV Infection. (One Treatment Arm Receives Placebo)CompletedNCT00000765Not applicable
• Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection.CompletedNCT00000764Phase 1
• A Placebo-Controlled, Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant Envelope Proteins of HIV-1 gp160 and gp120 in Children >= 1 Month Old With Asymptomatic HIV InfectionCompletedNCT00000762Phase 1
• A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV InfectionCompletedNCT00000760Phase 1
• Neurodevelopmental and Neurological Study of Infants and Children With HIV-1 Infection and AIDS in Clinical TrialsCompletedNCT00000759
• A Randomized Phase II Study of Two Doses of Interferon Alfa-2a (IFN Alfa-2a) in Combination With Zidovudine (AZT) and Dideoxycytidine (ddC) Versus AZT and ddC Only in Patients With HIV Infection and Less Than 400 CD4 Cells/mm3CompletedNCT00000754Phase 2
• Preventing Frequent Sinus Infections in HIV-Infected PatientsWithdrawnNCT00000752Phase 2
• A Phase III Study to Evaluate the Safety, Tolerance, and Efficacy of Early Treatment With Zidovudine (AZT) in Asymptomatic Infants With HIV InfectionCompletedNCT00000750Phase 3
• Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV InfectionCompletedNCT00000739Phase 1
• Foscarnet Treatment of Serious CMV Retinitis Infection in Patients With Acquired Immunodeficiency SyndromeCompletedNCT00000726Phase 1
• A Double-Blind, Placebo-Controlled Trial To Evaluate Intravenous Gamma Globulin in Children With Symptomatic HIV Infection Receiving ZidovudineCompletedNCT00000720Phase 3
• A Multicenter Trial To Evaluate Oral Retrovir in the Treatment of Children With Symptomatic HIV InfectionCompletedNCT00000716Phase 2
• A Multicenter, Double Blind, Comparative Study of Zidovudine Alone Versus Zidovudine and Acyclovir as Treatment for HIV-Infected Patients With CD4+ Counts Less Than 200 Cells/mm3CompletedNCT00000712Phase 2
• Aerosols in the Treatment of Asymptomatic Pneumocystis Pneumonia: A Pilot Study Assessing the Effectiveness of Aerosolized Pentamidine as Treatment of Subclinical Pneumocystis Infection in Patients With No Clinical SymptomsCompletedNCT00000707Not applicable
• Safety and Effectiveness of Azidothymidine (AZT) in HIV-Positive Patients With HemophiliaCompletedNCT00000705Phase 1
• A Multicenter Placebo-Controlled Double-Blind Trial to Evaluate Azidothymidine (AZT) Treatment of the AIDS Dementia Complex and Central Nervous System (CNS) Human Immunodeficiency Virus (HIV) InfectionCompletedNCT00000702Phase 3
• A Multi-Center Clinical Trial To Evaluate Azidothymidine (AZT) in the Treatment of Human Immunodeficiency Virus (HIV) Infection in Patients With AIDS Post First Episode PCPCompletedNCT00000700Phase 3
• A Treatment Protocol for the Use of Intravenous Ganciclovir in AIDS Patients With Immediately Sight-Threatening CMV RetinitisCompletedNCT00000698Phase 3
• A Study of Foscarnet in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS Who Cannot Use GanciclovirWithdrawnNCT00000697Phase 2
• A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment FailureCompletedNCT00000691Phase 2
• Randomized Comparative Study of Fluconazole Versus Clotrimazole Troches in the Prevention of Serious Fungal Infection in Patients With AIDS or Advanced AIDS-Related Complex. (A Nested Study of ACTG 081)CompletedNCT00000676Phase 3
• A Phase I/II Open-Labelled Trial of Intravitreal Ganciclovir Salvage Therapy for AIDS Patients With Active CMV Retinitis Who Are Intolerant of Systemic TherapyCompletedNCT00000673Phase 1
• A Phase II Efficacy Study Comparing 2',3'-Dideoxyinosine (ddI) (BMY-40900) and Zidovudine Therapy of Patients With HIV Infection Who Have Been on Long Term Zidovudine TreatmentCompletedNCT00000671Phase 2
• A Phase I Safety and Pharmacokinetics Study of 2',3'-Dideoxyinosine (ddI) Administered Twice Daily to Infants and Children With AIDS or Symptomatic HIV InfectionCompletedNCT00000669Phase 1
• A Phase I Pharmacokinetic and Tolerance Study of 28-Day Regimens of Oral GanciclovirCompletedNCT00000668Phase 1
• A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii InfectionCompletedNCT00000666Not applicable
• Studies of the Ocular Complications of AIDS (SOCA) CMV Retinitis Trial: Foscarnet-Ganciclovir ComponentCompletedNCT00000665Not applicable
• A Phase I Study of the Safety and Pharmacokinetics of Recombinant CD4 Immunoglobulin G (rCD4-IgG) in Infants and Children With Documented HIV-1 InfectionCompletedNCT00000663Phase 1
• The Tolerance of HIV-Infected Patients With Herpes Group Virus Infections to Oral Doses of FIAUCompletedNCT00000654Phase 2