Mclean Hospital: Depressive Disorder, Major trials

The registry lists 32 Depressive Disorder, Major studies with Mclean Hospital as lead sponsor. 7 are open to participants now and 11 have results posted.

Early Phase 1 2Phase 1 5Phase 2 3Phase 3 1Phase 4 5No phase 18(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101Not yet recruitingNCT07785102Early Phase 1
• Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive DisorderNot yet recruitingNCT07593222Phase 1/2
• Synaptic Mechanisms of Continuous Theta Burst Stimulation in DepressionRecruitingNCT07560878Early Phase 1
• Stress Dynamics and Familial Risk for Depression in Female AdolescentsRecruitingNCT06816329Not applicable
• Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major DepressionRecruitingNCT05630963
• Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Pharmacological ManipulationRecruitingNCT05232032Phase 2
• Neural Correlates of Stress and Perceived Control in Adolescent DepressionRecruitingNCT04788524Not applicable
• Fixed Dose Intervention Trial of New England Enhancing Survival in SMI PatientsCompletedNCT02188121Phase 4Results posted
• Brain Mechanisms of Human MotivationCompletedNCT01976975Results posted
• An Investigation of Early Life Stress and DepressionCompletedNCT01701258Phase 1Results posted
• Internet Based Cognitive Behavioral Therapy Effects on Depressive Cognitions and Brain FunctionCompletedNCT01598922Not applicableResults posted
• Glutamatergic and GABAergic Mediators of Antidepressant Response in Major DepressionCompletedNCT01557946Phase 4Results posted
• The Effects of Dopamine on Reward ProcessingCompletedNCT01253421Phase 1Results posted
• Lisdexamfetamine Dimesylate in Residual Symptoms and Cognitive Impairment in Major Depressive Disorder.CompletedNCT01148979Phase 4Results posted
• Low Field Magnetic Stimulation in Mood Disorders Using the LFMS DeviceCompletedNCT00578383Not applicableResults posted
• AndroGel in Men With Major Depression and Incomplete Response to Antidepressant TreatmentCompletedNCT00304746Phase 4Results posted
• Magnetic Resonance Imaging Study of Geriatric DepressionCompletedNCT00245557Not applicableResults posted
• The Effects of Wellbutrin (Bupropion) on Residual and Cognitive Symptoms in SSRI-treated DepressionCompletedNCT00125957Phase 3Results posted
• SMART Trial to Predict Anhedonia Response to Antidepressant TreatmentCompletedNCT05537584Phase 4
• Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant DepressionCompletedNCT04239963
• Biomarkers of Response to Treatment With Frontal Cortex Stimulation for Anxious DepressionTerminatedNCT03999736Phase 1/2
• Electrophysiological Correlates of Cognition in DepressionTerminatedNCT03998748Not applicable
• McLean and Genomind Prospective StudyCompletedNCT03113890Not applicable
• Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in DepressionCompletedNCT03031665
• Neuroimaging Studies of Reward Processing in DepressionCompletedNCT03026036
• Functional Brain Imaging Study of Response to Repetitive TMS (rTMS) Treatment of Major DepressionStatus unknownNCT01768052
• Genetic and Neural Predictors of Adolescent DepressionCompletedNCT01743716
• Neural Components Underlying the Treatment of Adolescent DepressionCompletedNCT01717508Not applicable
• Depression and Dopamine Transporter Function Study Using C-11 AltropaneCompletedNCT01701141
• Dopamine Neurotransmission in Major DepressionCompletedNCT01659814
• Functional and Neurochemical Correlates of Treatment Response in Major Depressive DisorderTerminatedNCT01598324
• Treatment Resistant Geriatric Depression in Primary CareCompletedNCT01392287Phase 1