M.D. Anderson Cancer Center: Brain Neoplasms trials

The registry lists 77 Brain Neoplasms studies with M.D. Anderson Cancer Center as lead sponsor. 13 are open to participants now and 13 have results posted.

Early Phase 1 3Phase 1 21Phase 2 29Phase 3 6Phase 4 2No phase 24(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• OBSERVE: A Pilot Study Of Omission Of Brain Metastasis Stereotactic Radiosurgery Following Resection With CNS-Active Systemic TherapyRecruitingNCT07655583Phase 1
• A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain CancersRecruitingNCT07467109
• Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)RecruitingNCT07053033Phase 2
• EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-activeRecruitingNCT06649058Phase 2
• Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)RecruitingNCT05700721Phase 2
• A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)RecruitingNCT05673928Phase 2
• A Comprehensive Clinical fMRI Software Solution to Enable Mapping of Critical Functional Networks and Cerebrovascular Reactivity in the BrainRecruitingNCT05342454
• Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain MetastasesRecruitingNCT05064280Phase 2
• A Phase II Study of Nivolumab With Ipilimumab and Cabozantinib in Patients With Untreated Renal Cell Carcinoma Brain MetastasesRecruitingNCT05048212Phase 2
• Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-OncologyRecruitingNCT04988009
• HSV G207 in Children With Recurrent or Refractory Cerebellar Brain TumorsRecruitingNCT03911388Phase 1
• Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain TumorsRecruitingNCT03830151Phase 1
• Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain TumorsRecruitingNCT02754544Not applicable
• Bintrafusp Alfa and Pimasertib for the Treatment of Patients With Brain MetastasesTerminatedNCT04789668Phase 1/2Results posted
• Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the BrainCompletedNCT03873818Phase 2Results posted
• Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With GlioblastomaCompletedNCT02661282Phase 1/2Results posted
• Glioblastoma Multiforme (GBM) Proton vs. Intensity Modulated Radiotherapy (IMRT)CompletedNCT01854554Phase 2Results posted
• Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent GlioblastomaTerminatedNCT01582152Phase 1/2Results posted
• TPI 287 in Patients With Recurrent Glioblastoma MultiformeTerminatedNCT01113463Phase 2Results posted
• Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)TerminatedNCT01110876Phase 1/2Results posted
• Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)CompletedNCT01067469Phase 2Results posted
• Bevacizumab and Lapatinib in Children With Recurrent or Refractory EpendymomaCompletedNCT00883688Phase 2Results posted
• Tarceva With Whole Brain Radiation Therapy - Brain Mets From Non-Small Cell Lung CancerCompletedNCT00871923Phase 2Results posted
• 6-TG, Capecitabine and Celecoxib Plus TMZ or CCNU for Anaplastic Glioma PatientsCompletedNCT00504660Phase 2Results posted
• Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain TumorsTerminatedNCT00488644Not applicableResults posted
• Effects of Methylphenidate Versus Sustained Release Methylphenidate on Cognitive FunctioningTerminatedNCT00418691Phase 3Results posted
• Study of Lenvatinib Plus Pembrolizumab in IO Refractory mRCC Patients With Brain MetastasesWithdrawnNCT07011849Phase 2
• A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on ImmunotherapyTerminatedNCT06015295Not applicable
• A Virtually Delivered Exercise Intervention To Mitigate Cognitive Deficits From Radiotherapy In AYAs With Brain TumorsTerminatedNCT05554159Not applicable
• The Effects of Spiritual Needs on Spiritual Well-Being in Patients With Brain Tumors: A Structural Equation Modeling ApproachWithdrawnNCT05356507
• A Phase 1a/1b Study to Determine the Recommended Phase 2 Dose, of Tepotinib in Participants With MET Alterations and Brain TumorsWithdrawnNCT05120960Phase 1
• MRI and Blood Biomarkers for the Prediction of Neurocognitive Decline Following Brain RadiationTerminatedNCT05087888
• Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain MetastasesCompletedNCT05054998Phase 4
• Study of Laser Interstitial Thermal Therapy (LITT) Treatment Response Assessment With Fluciclovine PET MRWithdrawnNCT05054400Early Phase 1
• Comprehensive Evaluation of Tumor Oxygenation, Metabolism and Blood Supply of High Grade Glioma and Cervical Cancers Using Dynamic FAZA PET and Multiparametric MRActive, not recruitingNCT05047913Early Phase 1
• Seizure Control as a New Metric in Assessing Efficacy of Tumor Treatment in Patients With Low Grade GliomaActive, not recruitingNCT04553757
• Chemotherapy and Donor Stem Transplant for the Treatment of Patients With High Grade Brain CancerWithdrawnNCT04521946Phase 1
• Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain MetastasisActive, not recruitingNCT04516070Phase 2
• Novel MRI Techniques for the Characterization and Treatment Assessment of High Grade Brain LesionsCompletedNCT04132843Not applicable
• nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor CortexActive, not recruitingNCT04062305Not applicable
• Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain MetastasesActive, not recruitingNCT03741673Phase 3
• Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Brain TumorsActive, not recruitingNCT03606161Not applicable
• Mind-Body Intervention in Glioma CouplesActive, not recruitingNCT03244995Not applicable
• Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain MetastasesActive, not recruitingNCT03175432Phase 2
• Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV MelanomaActive, not recruitingNCT02910700Phase 2
• Frameless Fractionated Stereotactic Radiation in Treating Patients With Brain MetastasesCompletedNCT02798029Phase 2
• Radiation Therapy in Treating Patients With Recurrent Brain Tumors Who Have Undergone Previous Radiation TherapyActive, not recruitingNCT02698254Not applicable
• Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung CancerActive, not recruitingNCT02696993Phase 1/2
• Dasatinib, Temsirolimus, and Cyclophosphamide in Treating Patients With Advanced, Recurrent, or Refractory Solid TumorsActive, not recruitingNCT02389309Phase 1
• Fluoro-L-Thymidine Positron Emission Tomography (FLT PET) vs. Adv. Magnetic Resonance (MR) Techniques in Recurrent GliomaWithdrawnNCT02241668Not applicable
• Use of Navigated Transcranial Magnetic Stimulation (nTMS) in Generated Motor and Language Mapping to Evaluate Brain Recovery Following SurgeryWithdrawnNCT02165995Not applicable
• STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the BrainCompletedNCT01904123Phase 1
• Phase I/II Cabazitaxel for Recurrent Malignant GliomaWithdrawnNCT01740570Phase 1/2
• Methotrexate Infusion Into the Fourth Ventricle in Children With Malignant Fourth Ventricular Brain Tumors: A Pilot StudyCompletedNCT01737671Early Phase 1
• Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain MetastasesActive, not recruitingNCT01644591Phase 2
• Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain MetastasesActive, not recruitingNCT01592968Phase 3
• Diffuse Intrinsic Pontine Glioma (DIPG) Reirradiation (ReRT)CompletedNCT01469247Phase 1/2
• 18-F-Fluoroacetate as PET Imaging AgentWithdrawnNCT01320787Phase 1
• Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain MetastasesActive, not recruitingNCT00950001Phase 3
• Fatigue, Sleep and Cytokines in Primary Brain Tumor (PBT) PatientsCompletedNCT00876499
• Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the UrotheliumActive, not recruitingNCT00756639Phase 2
• Brain Tumor Patient-Caregiver Congruence, MD Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT)CompletedNCT00748774
• Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain TumorsTerminatedNCT00720837Not applicable
• Intraoperative Optical Imaging of Brain FunctionWithdrawnNCT00632437
• Randomized Trial Comparing Radiosurgery With vs Without Whole Brain RadiotherapyCompletedNCT00548756Phase 3
• Temozolomide, Thalidomide, and Lomustine (TTL) in Melanoma PatientsCompletedNCT00527657Phase 1
• Valproate and Etoposide for Patients With Neuronal Tumors and Brain MetastasesCompletedNCT00513162Phase 1
• RTA 744 Injection in Patients With Leptomeningeal DiseaseTerminatedNCT00512460Phase 1
• Cognitive Training in Attenuating Attention Deficits/Child Treatment for CancerActive, not recruitingNCT00498719
• Nuclear Imaging of Human CSF Flow Using Ga-67 Citrate and In-111 DTPATerminatedNCT00477503Phase 1
• Surgery Versus Stereotactic Radiosurgery in the Treatment of Single Brain Metastasis: A Randomized TrialCompletedNCT00460395Phase 3
• Gliogene: Brain Tumor Linkage StudyStatus unknownNCT00418899
• Treatment of Resectable Malignant Brain TumorsTerminatedNCT00415467Phase 4
• Experience of Brain Tumor CaregiversCompletedNCT00352820
• Capecitabine and Pegylated Interferon Alfa-2a in Treating Patients With Recurrent or Progressive Brain Metastases Due to Breast CancerTerminatedNCT00227656Phase 2
• Phase I Trial of Intramural Injection of DTI-015 for Recurrent Malignant GliomasCompletedNCT00038441Phase 1/2
• Study of Vioxx and Radiation Therapy for Brainstem GliomaTerminatedNCT00038389Phase 1