LEO Pharma: Psoriasis trials

The registry lists 76 Psoriasis studies with LEO Pharma as lead sponsor. 1 are open to participants now and 35 have results posted.

Phase 1 19Phase 2 25Phase 3 19Phase 4 5No phase 9(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A 16-week Trial to Investigate the Efficacy and Safety of Delgocitinib Cream 20 mg/g in Adult Participants With Mild to Severe Palmoplantar PustulosisRecruitingNCT07013201Phase 2
• Efficacy and Safety of Brodalumab Compared With Guselkumab in the Treatment of Plaque Psoriasis After Inadequate Response to UstekinumabTerminatedNCT04533737Phase 4Results posted
• Efficacy and Safety of Brodalumab in Adolescents From 12 to 17 Years of Age With Moderate-to-severe Plaque PsoriasisTerminatedNCT04305327Phase 3Results posted
• Efficacy and Safety of LEO 90100 Foam in Japanese Subjects With Psoriasis VulgarisCompletedNCT03806790Phase 3Results posted
• A Trial Comparing the Efficacy of Subcutaneous Injections of Brodalumab to Oral Administrations of Fumaric Acid Esters in Adults With Moderate to Severe Plaque PsoriasisCompletedNCT03331835Phase 4Results posted
• LEO 90100 Twice Weekly Maintenance Regimen for Psoriasis VulgarisCompletedNCT02899962Phase 3Results posted
• LEO 80185 Gel (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With PsoriasisCompletedNCT02668692Phase 3Results posted
• A Psoriasis Plaque Test Trial With LEO 90100 Compared to Betesil® in Patients With Psoriasis VulgarisCompletedNCT02518048Phase 2Results posted
• Safety and Efficacy of Once Daily Topical Treatment With LEO 90100 Aerosol Foam in Adolescent Subjects With Plaque PsoriasisCompletedNCT02387853Phase 2Results posted
• Patient Insights Following Use of LEO 90100 Aerosol Foam and Daivobet® Gel in Subjects With Psoriasis VulgarisCompletedNCT02310646Phase 3Results posted
• LEO 90100 Aerosol Foam Compared to Calcipotriol Plus Betamethasone Dipropionate Gel in Subjects With Psoriasis VulgarisCompletedNCT02132936Phase 3Results posted
• An International, Multi-centre, Prospective, Non-controlled, Open, Single-group, 8-week Trial in Adolescent SubjectsCompletedNCT02038569Phase 2Results posted
• LEO 90100 Compared to Vehicle in Subjects With Psoriasis VulgarisCompletedNCT01866163Phase 3Results posted
• The Pharmacokinetics of LEO 90105 (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Japanese Subjects With Extensive Psoriasis VulgarisCompletedNCT01768013Phase 1/2Results posted
• Non-interventional Study of Long-term Treatment of Psoriasis With Calcipotriol Plus Betamethasone in Gel FormulationCompletedNCT01707368Results posted
• A Short-contact Plaque Test Study With Daivobet® Gel in Psoriasis VulgarisCompletedNCT01607853Phase 2Results posted
• Effect of LEO 90100 on the HPA Axis and Calcium Metabolism in Subjects With Extensive Psoriasis VulgarisExtensive Psoriasis VulgarisCompletedNCT01600222Phase 2Results posted
• A Plaque Test Study With LEO 35299 in Psoriasis VulgarisCompletedNCT01580488Phase 1Results posted
• LEO 90100 in the Treatment of Psoriasis VulgarisCompletedNCT01536938Phase 2Results posted
• LEO 90100 Compared With Calcipotriol Plus Betamethasone Dipropionate Ointment, LEO 90100 Vehicle and Ointment Vehicle in Subjects With Psoriasis VulgarisCompletedNCT01536886Phase 2Results posted
• LEO 90105 Ointment in Japanese Subjects With PsoriasisCompletedNCT01422434Phase 3Results posted
• A Psoriasis Plaque Test Study With LEO 90100 Cutaneous Spray, Ointment, in Psoriasis VulgarisCompletedNCT01347255Phase 2Results posted
• Efficacy and Safety of Xamiol® Gel Compared to Calcipotriol Scalp Solution in Patients With Scalp PsoriasisCompletedNCT01195831Phase 3Results posted
• LEO 80185 in the Treatment of Psoriasis Vulgaris on the Non-scalp Regions of the Body (Trunk and/or Limbs)CompletedNCT01188928Phase 3Results posted
• Safety and Efficacy of LEO 80185 Gel in Adolescent Subjects (Aged 12 to 17) With Scalp PsoriasisCompletedNCT01120223Phase 2Results posted
• A Proof of Concept Study Comparing Three Doses of an Oral Solution of LEO 22811 With a Placebo Oral Solution for the Treatment of Psoriasis VulgarisCompletedNCT01116895Phase 2Results posted
• Safety and Efficacy of LEO 80185 Topical Suspension in Adolescent Subjects (Aged 12 to 17) With Scalp PsoriasisCompletedNCT01083758Phase 2Results posted
• A Study Comparing LEO 80190 Ointment With Hydrocortisone Ointment, Both Applied Once Daily in the Treatment of Psoriasis Vulgaris on the Face and Intertriginous AreasCompletedNCT01007591Phase 3Results posted
• A Psoriasis Plaque Test With LEO 29102 Cream and Its Combination ProductsCompletedNCT00875277Phase 2Results posted
• A Plaque Test Comparing the Anti-psoriatic Effect of Marketed Products for Topical Use for Psoriasis VulgarisCompletedNCT00845481Phase 2Results posted
• Safety and Efficacy of TACLONEX Ointment in Adolescent Patients (Aged 12 to 17 Years) With Psoriasis VulgarisCompletedNCT00817219Phase 2Results posted
• Efficacy and Safety of LEO 19123 Cream in the Treatment of Psoriasis VulgarisCompletedNCT00764751Phase 2Results posted
• Effect of Calcipotriol Plus Hydrocortisone Ointment on the Adrenal Hormone Balance and Calcium Metabolism in Patients With Psoriasis Vulgaris on the Face and Skin FoldsCompletedNCT00704262Phase 2Results posted
• Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment in Psoriasis Vulgaris on the Face and Skin FoldsCompletedNCT00691002Phase 3Results posted
• Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel Compared With Tacalcitol Ointment and the Gel Vehicle Alone in Patients With Psoriasis VulgarisCompletedNCT00670241Phase 3Results posted
• Efficacy and Safety of Calcipotriol Plus Hydrocortisone Ointment Compared With Tacalcitol Ointment in Patients With Psoriasis on the Face and Skin FoldsCompletedNCT00640822Phase 3Results posted
• A Study to Test Whether Spesolimab Helps People With Generalized Pustular Psoriasis (GPP) Who Need Treatment for Repeated FlaresActive, not recruitingNCT06013969Phase 4
• Clinical Trial to Assess Safety, Tolerability and the Pharmacodynamics Effect of Calcipotriol/Betamethasone Dipropionate in a New Administration Form in Subjects With Chronic Plaque Psoriasis.CompletedNCT03898583Phase 1
• Effisayil™ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous StudyActive, not recruitingNCT03886246Phase 2
• Clinical Trial to Assess Safety, Tolerability and the Pharmacodynamic Effect of Different Concentrations of a New Anti-inflammatory Substance in Subjects With Chronic Plaque PsoriasisCompletedNCT03669757Phase 1
• Skin Irritation of LEO 90100 Foam (Calcipotriol Hydrate Plus Betamethasone Dipropionate) in Healthy Japanese SubjectsCompletedNCT03442244Phase 1
• Body PSOriasis: Long-term Relapse CONTROLCompletedNCT03402828
• Multiple Dose Study With Incremental Dosing to Evaluate the Safety, Tolerability, and Pharmacokinetics of Oral Doses of LEO 32731 in Healthy Male Japanese Subjects.CompletedNCT03231124Phase 1
• Vasoconstriction Trial With LEO 90100 Aerosol FoamCompletedNCT02973776Phase 1
• PSOREAL - Managing PSOriasis in the REAL WorldCompletedNCT02935582
• LEO 32731 for the Treatment of Moderate to Severe Psoriasis VulgarisCompletedNCT02888236Phase 2
• Efficacy and Tolerability of Enstilar® in Daily PracticeCompletedNCT02881346
• Real-life Evaluation of the Daivobet® Gel ApplicatorCompletedNCT02856542
• A Phase I Study With LEO 32731 and Midazolam in Healthy Male SubjectsTerminatedNCT02753218Phase 1
• Trial Twice Daily Application of LEO 124249 Ointment 30 mg/g in Treatment of Mild to Moderate Inverse PsoriasisCompletedNCT02695940Phase 2
• Xamiol®Gel in BODY Psoriasis: A One-year Non-interventional StudyCompletedNCT02636101
• Dermatopharmacokinetic Trial of LEO 80185 GelCompletedNCT02605057Phase 1
• Long-term Treatment of Scalp Psoriasis With Xamiol® Gel in a Large Adult Chinese PopulationCompletedNCT02533973Phase 4
• LEO 32731 - A Phase I Study in Healthy SubjectsCompletedNCT02514694Phase 1
• A Psoriasis Plaque Test Trial With LP0113 Spray in Patients With Psoriasis Vulgaris (LP0113-1123)CompletedNCT02416258Phase 2
• LP0058-1005 - A Open-Label, Four-Way Crossover and Food-Effect Study of LEO 32731 in Healthy SubjectsCompletedNCT02126371Phase 1
• An Observational Study to Assess Patient Satisfaction and Control of Psoriasis With Calcipotriene/Betamethasone Dipropionate (Taclonex®) Topical Suspension, and Effect on Quality of LifeCompletedNCT01982552
• A Vasoconstriction Study With LEO 90100CompletedNCT01946386Phase 1
• Combined Cumulative Irritation Potential and Repeat Insult Patch Test of LEO 90100CompletedNCT01935869Phase 1
• An Exploratory Psoriasis Plaque Test Study With Different Dose Combinations of Calcipotriol Plus Betamethasone Dipropionate in the Daivobet® Gel Vehicle in Psoriasis VulgarisCompletedNCT01837576Phase 1
• Cromoglicate in PsoriasisCompletedNCT01722812Phase 2
• An Exploratory Psoriasis Plaque Test Study With LEO 29102 Plus Calcipotriol, Ointment, in Psoriasis VulgarisCompletedNCT01466478Phase 1
• Efficacy, Tolerability and Handling of Daivobet® Gel in Patients With Psoriasis VulgarisCompletedNCT01320774
• A Psoriasis Plaque Test on LEO 27989 Ointment and Calcipotriol Plus LEO 27989 Ointment in Patients With Psoriasis VulgarisCompletedNCT01297166Phase 1
• Effect of LEO 80185 Gel on the HPA Axis and Calcium Metabolism in Subjects With Extensive Psoriasis VulgarisCompletedNCT01229098Phase 2
• A Psoriasis Plaque Test Comparing Eight Different Formulations of Vitamin D Analogues for the Treatment of PsoriasisCompletedNCT01105286Phase 1
• Topical Treatment of Scalp Psoriasis With the Fixed Combination of Calcipotriol and Betamethason (Xamiol® Gel)CompletedNCT01052467
• A Psoriasis Plaque Test Comparing Products for the Treatment of Psoriasis VulgarisCompletedNCT01043224Phase 1
• LEO 22811 - A Phase 1, Double-Blind, Placebo-controlled, Single and Multiple Oral Dose Study in Healthy SubjectsCompletedNCT00833872Phase 1
• Efficacy and Safety of Calcipotriene/Betamethasone Gel/Ointment in PsoriasisCompletedNCT00279162Phase 3
• Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel in Psoriasis VulgarisCompletedNCT00263718Phase 2
• Efficacy of Calcipotriol Plus Betamethasone Gel Versus Calcipotriol Scalp Solution in Scalp PsoriasisCompletedNCT00243464Phase 3
• Efficacy and Safety of Calcipotriol Cream and (Calcipotriol + Betamethasone Dipropionate) Ointment in Psoriasis VulgarisCompletedNCT00216892Phase 4
• Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel for up to a Year in Scalp PsoriasisCompletedNCT00216879Phase 3
• Efficacy and Safety of Calcipotriol Plus Betamethasone Dipropionate Gel in Scalp PsoriasisCompletedNCT00216840Phase 3
• Efficacy and Safety of Calcipotriol Plus Betamethasone Gel in the Treatment of Scalp PsoriasisCompletedNCT00216827Phase 3