Eisai Co., Ltd.: Seizures trials

The registry lists 51 Seizures studies with Eisai Co., Ltd. as lead sponsor. 2 are open to participants now and 27 have results posted.

Phase 2 8Phase 3 19Phase 4 9No phase 15(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• A Study to Evaluate the Safety of Fycompa Injection in Participants With Partial-Onset Seizures or Primary Generalized Tonic- Clonic SeizuresRecruitingNCT06657378
• An Extended Access Program (EAP) for Participants Who Have Completed Rufinamide Study E2080-G000-303AvailableNCT03778424
• A Study of Lorcaserin as Adjunctive Treatment in Participants With Dravet SyndromeTerminatedNCT04572243Phase 3Results posted
• A Study of Intravenous Perampanel in Japanese Participants With EpilepsyCompletedNCT03754582Phase 2Results posted
• Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic SeizuresCompletedNCT03288129Phase 4Results posted
• Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study)CompletedNCT03201900Phase 3Results posted
• Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic SeizuresCompletedNCT02849626Phase 3Results posted
• Study of Perampanel as Adjunctive Treatment for Inadequately Controlled Seizures Associated With Lennox-Gastaut SyndromeTerminatedNCT02834793Phase 3Results posted
• Trial Evaluating the Efficacy and Safety of Perampanel Added to Monotherapy in Participants With Partial Onset Seizures With or Without Secondary GeneralizationCompletedNCT02726074Phase 4Results posted
• A Study With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Perampanel (E2007) Administered as an Adjunctive Therapy in Subjects With Refractory Partial-onset SeizuresCompletedNCT01618695Phase 3Results posted
• A Study to Evaluate the Safety and Tolerability and Explore the Efficacy of Zonisamide as add-on Therapy in Elderly Patients With Refractory Partial SeizuresTerminatedNCT01546688Phase 4Results posted
• A Efficacy and Safety Study of Adjunctive Perampanel in Primary Generalized Tonic Clonic SeizuresCompletedNCT01393743Phase 3Results posted
• A Study to Assess the Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Extension Study)CompletedNCT01136954Phase 3Results posted
• A Long-term Extension Study of E2007 in Patients With Refractory Partial Seizures Uncontrolled With Other Anti-Epileptic Drugs (AEDs)CompletedNCT00903786Phase 2Results posted
• An add-on Study of E2007 in Patients With Refractory Partial Seizures Uncontrolled With Other Anti-epileptic Drugs (AEDs)CompletedNCT00849212Phase 2Results posted
• Assessing The Long-Term Safety And To Explore The Long-Term Efficacy Of Zonisamide As Monotherapy In Newly Diagnosed Partial SeizuresCompletedNCT00848549Phase 3Results posted
• Evaluation of the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial SeizuresCompletedNCT00735397Phase 3Results posted
• Evaluating Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial SeizuresCompletedNCT00700310Phase 3Results posted
• Evaluating the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial SeizuresCompletedNCT00699972Phase 3Results posted
• To Evaluate The Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial SeizuresCompletedNCT00699582Phase 3Results posted
• Efficacy and Safety of Adjunctive Zonisamide in Myoclonic Seizures Associated With Idiopathic Generalised EpilepsyTerminatedNCT00693017Phase 3Results posted
• Adjunctive Zonisamide in Primary Generalised Tonic Clonic SeizuresTerminatedNCT00692003Phase 3Results posted
• Efficacy and Safety of Adjunctive Zonisamide in Paediatric Partial Onset Seizures (CATZ Study)CompletedNCT00566254Phase 3Results posted
• Open-Label Extension Study of Rufinamide Given as Adjunctive Therapy in Patients With Refractory Partial SeizuresTerminatedNCT00448539Phase 3Results posted
• Exploring the Safety And Tolerability of Doses of E2007 up to a Maximum of 12 mg In Patients With Refractory Partial SeizuresCompletedNCT00416195Phase 2Results posted
• 4-Year Open-Label Extension Phase of the Parallel-Group Study of E2007 in Patients With Refractory Partial SeizuresCompletedNCT00368472Phase 2Results posted
• Rufinamide Given as Adjunctive Therapy in Participants With Refractory Partial SeizuresCompletedNCT00334958Phase 3Results posted
• Evaluating the Efficacy and Safety of Zonisamide in the Treatment of Partial SeizuresCompletedNCT00327717Phase 3Results posted
• A Study for Evaluating the Efficacy and Safety of Zonisamide and Lamotrigine (Lamictal) for Subjects With Refractory Simple Partial, Complex Partial or Partial With Secondary Generalized SeizuresCompletedNCT00292461Phase 3Results posted
• A Retrospective Database Study for the Development and Validation of Algorithms for Intracerebral Hemorrhage and Seizures in Alzheimer's DiseaseActive, not recruitingNCT07723950
• A Study to Evaluate the Efficacy and Safety of Perampanel Monotherapy in Untreated Participants With Focal Onset Seizures With or Without Focal to Bilateral Tonic-clonic SeizuresCompletedNCT05533814Phase 4
• A Study of Perampanel as Add-on Therapy in Adult and Adolescent Participants With Focal SeizuresCompletedNCT04257604
• A Study to Investigate Dosage, Effectiveness, and Safety of Perampanel When Used as First Add-on Therapy in Participants >=12 Years With Partial Onset Seizures With or Without Secondary Generalization or With Primary Generalized Tonic-Clonic Seizures Associated With Idiopathic Generalized EpilepsyCompletedNCT04252846
• A Study to Evaluate the Safety and Efficacy of Fycompa® (Perampanel) as Add-on Therapy in Participants With EpilepsyCompletedNCT04230044
• A Study to Evaluate the Effectiveness of Perampanel as Only Add-on Treatment in Participants With Primary or Secondarily Generalized Tonic-clonic SeizuresCompletedNCT04202159
• A Study to Evaluate Efficacy and Safety of Perampanel Administered as an Adjunctive Therapy in Pediatric Participants With Childhood EpilepsyActive, not recruitingNCT04015141Phase 2
• A Study to Assess Safety and Efficacy of Perampanel in Indian Participants as an Adjunctive Treatment in Partial Onset Seizures With or Without Secondary Generalized Seizures in Participants With Epilepsy Aged 12 Years or OlderCompletedNCT03836924
• Safety and Pharmacokinetics Study of E2007 to Treat Partial and Generalised Seizures in People With EpilepsyCompletedNCT03780907Phase 2
• Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic SeizuresCompletedNCT03059381
• Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic SeizuresCompletedNCT03059329
• Study to Investigate Dosage, Efficacy, and Safety of Perampanel Given as Monotherapy in Patients With EpilepsyCompletedNCT02736162
• To Evaluate the Effect of Perampanel on Objective and Subjective Sleep in Subjects With Insomnia and Partial Onset SeizuresWithdrawnNCT02220972Phase 4
• An Extended Access Program for PerampanelNo longer availableNCT01871233
• A Post-marketing Observational Study Of The Use Of Zonisamide (ZNS) in the Adjunctive Treatment Of Adult Patients With Partial Onset Seizures (Study E2090-E044-410) (ZOOM)CompletedNCT01830868
• A Post-marketing Study Evaluating Eslicarbazepine Acetate (ESL) as Adjunctive Treatment in Partial-Onset Seizures (Study E2093-E044-404) (EPOS)CompletedNCT01830400
• Evaluation of the Efficacy and Safety of Adjunctive Zonisamide vs Replacement With Zonisamide of the Last Added Antiepileptic DrugCompletedNCT01630057Phase 4
• A Study to Evaluate the Safety and Efficacy of Zonisamide an Antiepileptic Drug as Monotherapy or Adjunctive Therapy in Treatment of Adult Patients With Partial, Generalized or Combined Seizures.CompletedNCT01283256
• ZAGAL Study: Evaluating Effectiveness and Tolerability of Zonisamide as Adjunctive Therapy in Patients With Partial Onset Seizures Treated With Two Antiepileptic DrugsCompletedNCT00659958Phase 4
• Open Label, Zonegran (Zonisamide) In Partial Onset SeizuresCompletedNCT00215592Phase 4
• Efficacy and Safety of an add-on Treatment With Zonisamide in Adults With Focal Epileptic Seizures With or Without Secondary GeneralizationTerminatedNCT00165828Phase 4
• E2007 Given as Adjunctive Therapy in Patients With Refractory Partial SeizuresCompletedNCT00144690Phase 2