Duke University: Heart Failure trials

The registry lists 55 Heart Failure studies with Duke University as lead sponsor. 5 are open to participants now and 26 have results posted.

Phase 1 2Phase 2 10Phase 3 9Phase 4 5No phase 31(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological DistressNot yet recruitingNCT07634419Not applicable
• Chronic Exogenous Ketosis in HFpEFEnrolling by invitationNCT06937320Phase 2
• Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection FractionRecruitingNCT06733012Not applicable
• Goal Concordant Care Learning LaboratoryEnrolling by invitationNCT05879211Not applicable
• Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)RecruitingNCT04278404
• Ketone Pharmacokinetic Study in HFrEFCompletedNCT05757193Phase 1Results posted
• Efficacy and Safety of ICD Remote Monitored Exercise Testing to Improve Heart Failure Outcomes: REMOTE HF-ACTIONCompletedNCT04629066Not applicableResults posted
• Splanchnic Nerve Block for Therapy of Chronic Heart Failure (Splanchnic III)CompletedNCT04575428Phase 2Results posted
• Daxor - Blood Volume AnalysisCompletedNCT04111185Not applicableResults posted
• Abdominal Nerve Blockade in Chronic Heart Failure.CompletedNCT03453151Phase 1/2Results posted
• TRANSFORM-HF: ToRsemide compArisoN With furoSemide FORManagement of Heart FailureCompletedNCT03296813Phase 3Results posted
• Inhaled Selective Pulmonary Vasodilators for Advanced Heart Failure Therapies and Lung Transplantation OutcomesCompletedNCT03081052Phase 4Results posted
• Hepatitis C Virus(HCV) Heart and Lung StudyCompletedNCT02858180Phase 4Results posted
• Predischarge Initiation of Ivabradine in the Management of Heart Failure (PRIME-HF)CompletedNCT02827500Phase 4Results posted
• EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study)CompletedNCT02816736Phase 4Results posted
• Splanchnic Nerve Anesthesia in Heart FailureCompletedNCT02669407Not applicableResults posted
• Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart FailureCompletedNCT02235077Phase 2Results posted
• Functional Impact of GLP-1 for Heart Failure Treatment (FIGHT)CompletedNCT01800968Phase 2Results posted
• Guiding Evidence Based Therapy Using Biomarker Intensified TreatmentTerminatedNCT01685840Not applicableResults posted
• Targeting Acute Congestion With Tolvaptan in Congestive Heart FailureCompletedNCT01644331Phase 3Results posted
• Palliative Care in Heart FailureCompletedNCT01589601Not applicableResults posted
• Right Ventricular (RV) Pacing in Early Post-operative Continuous Flow Left Ventricular Assist Device (LVAD)TerminatedNCT01446796Phase 4Results posted
• Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial)TerminatedNCT01169493Not applicableResults posted
• Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) StudyCompletedNCT01132846Phase 2Results posted
• Using Allopurinol to Relieve Symptoms in Patients With Heart Failure and High Uric Acid LevelsCompletedNCT00987415Phase 2Results posted
• Evaluating the Effectiveness of Sildenafil at Improving Health Outcomes and Exercise Ability in People With Diastolic Heart Failure (The RELAX Study)CompletedNCT00763867Phase 3Results posted
• Effectiveness of Ultrafiltration in Treating People With Acute Decompensated Heart Failure and Cardiorenal Syndrome (The CARRESS Study)CompletedNCT00608491Phase 3Results posted
• Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart FailureTerminatedNCT00608140Phase 3Results posted
• Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)CompletedNCT00577135Phase 3Results posted
• Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart FailureCompletedNCT00078286Phase 2/3Results posted
• Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery DiseaseCompletedNCT00023595Phase 3Results posted
• Evaluation Of A Virtual Cardiology Program To Improve Outcomes After Acute Decompensated Heart FailureCompletedNCT06592508Not applicable
• Ketones in Heart Failure With Reduced Ejection FractionCompletedNCT06195982Phase 2
• Optimizing In-hospital Use of Evidence-based Therapies for Patients With Cardio-Renal-Metabolic DiseaseCompletedNCT05781334Not applicable
• Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)WithdrawnNCT05704595Not applicable
• Lymph Drainage in Heart FailureCompletedNCT05240638Not applicable
• Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation StudyCompletedNCT03775759Not applicable
• Cardiac Rehabilitation and Metabolomics in Heart FailureCompletedNCT03743012Not applicable
• Reducing Disparities in the Quality of Advance Care Planning for Older AdultsCompletedNCT03516994Not applicable
• Effective Management of Emotional Response to Generate Well-Being Post-HF ExacerbationCompletedNCT03043261Not applicable
• Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart FailureCompletedNCT03035474Not applicable
• Mobile Health Behavioral Intervention in Patients With Heart Failure and Diabetes MellitusCompletedNCT02918175Not applicable
• Characterizing HIV-related Diastolic DysfunctionCompletedNCT02860156
• Feasibility of Cardiac Rehabilitation in Patients With Heart Failure at the Moi Teaching and Referral HospitalCompletedNCT02795936Not applicable
• Depression and Heart Failure Disease ProgressionCompletedNCT02131428
• Exercise, Heart Failure, and Type 2 DiabetesWithdrawnNCT02122835Not applicable
• Heart Failure and Regional Specific Exercise Training StimulusWithdrawnNCT02077426Not applicable
• Automated MEdical Record Driven Implantable CArdioverter-defibrillator Heart Failure Trial (AMERICA-HF)TerminatedNCT01807130Not applicable
• Preliminary Study Examining Heart Failure Patients Responses to Depression EducationTerminatedNCT01794598Not applicable
• Care Transitions for Complex Patient - Cycle 1 and Cycle 2CompletedNCT01039324Not applicable
• Centers for Education on Research and Therapeutics - Heart Failure: Targeted Intervention StudyCompletedNCT00979264Not applicable
• Coping Skills and Heart Failure: Outcomes and MechanismsCompletedNCT00873418Not applicable
• Validating PROMIS Instruments in Congestive Heart Failure Patients Receiving a Heart TransplantCompletedNCT00783848
• STARBRITE: A Randomized Pilot Trial of BNP-Guided Therapy in Patients With Advanced Heart FailureCompletedNCT00484770Phase 2
• Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart FailureCompletedNCT00047437Phase 3