Cytokinetics: Heart Failure trials

The registry lists 13 Heart Failure studies with Cytokinetics as lead sponsor. 2 are open to participants now and 7 have results posted.

Phase 1 1Phase 2 8Phase 3 4(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEFRecruitingNCT06793371Phase 2
• Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection FractionRecruitingNCT06736574Phase 3
• Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart FailureCompletedNCT03759392Phase 3Results posted
• Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection FractionCompletedNCT02929329Phase 3Results posted
• Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection FractionCompletedNCT02695420Phase 2Results posted
• COSMIC-HF - Chronic Oral Study of Myosin Activation to Increase Contractility in Heart FailureCompletedNCT01786512Phase 2Results posted
• Pharmacokinetics of Oral CK-1827452 in Patients With Stable Heart FailureCompletedNCT00941681Phase 2Results posted
• Phase II Study of the Effect of CK-1827452 Injection on Myocardial EfficiencyTerminatedNCT00748579Phase 2Results posted
• A Study of CK-1827452 Infusion in Stable Heart FailureCompletedNCT00624442Phase 2Results posted
• Omecamtiv Mecarbil Post-trial Access StudyWithdrawnNCT04464525Phase 3
• A Pharmacokinetic and Pharmacodynamic Study of Omecamtiv Mecarbil in Healthy VolunteersCompletedNCT01380223Phase 1
• Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)CompletedNCT01300013Phase 2
• Pharmacokinetic Study of Omecamtiv Mecarbil in Heart Failure PatientsWithdrawnNCT01077167Phase 2