Children's Oncology Group: Central Nervous System Neoplasms trials

The registry lists 42 Central Nervous System Neoplasms studies with Children's Oncology Group as lead sponsor. 2 are open to participants now and 12 have results posted.

Phase 1 15Phase 2 12Phase 3 5No phase 11(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Somatic Mosaicism in Twins Discordant for Childhood CancerRecruitingNCT06054295
• Project: Every Child for Younger Patients With CancerRecruitingNCT02402244
• Larotrectinib in Treating Patients With Previously Untreated TRK Fusion Solid Tumors and TRK Fusion Relapsed Acute LeukemiaActive, not recruitingNCT03834961Phase 2Results posted
• Pevonedistat, Irinotecan, and Temozolomide in Treating Patients With Recurrent or Refractory Solid Tumors or LymphomaCompletedNCT03323034Phase 1Results posted
• Nanoparticle Albumin-Bound Rapamycin, Temozolomide, and Irinotecan Hydrochloride in Treating Pediatric Patients With Recurrent or Refractory Solid TumorsCompletedNCT02975882Phase 1Results posted
• Prexasertib in Treating Pediatric Patients With Recurrent or Refractory Solid TumorsCompletedNCT02808650Phase 1Results posted
• Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade GliomasCompletedNCT02323880Phase 1Results posted
• Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other MalignancyCompletedNCT00716976Phase 3Results posted
• Radiation Therapy in Treating Young Patients With GliomasCompletedNCT00238264Phase 2Results posted
• Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed GliomasCompletedNCT00100802Phase 2Results posted
• Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell TumorCompletedNCT00085098Phase 3Results posted
• Carboplatin, Vincristine, and Temozolomide in Treating Children With Progressive and/or Symptomatic Low-Grade GliomaCompletedNCT00077207Not applicableResults posted
• Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell TumorsCompletedNCT00047320Phase 2Results posted
• Observation or Radiation Therapy and/or Chemotherapy and Second Surgery in Treating Children Who Have Undergone Surgery for EpendymomaCompletedNCT00027846Phase 2Results posted
• Studying Gene Expression and Location in Samples From Patients With Brain TumorsCompletedNCT01585389
• Studying Gene Expression in Samples From Patients With Rhabdoid TumorsCompletedNCT01553175
• Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing CancerCompletedNCT01353300
• Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or LymphomaCompletedNCT01273090Phase 1
• Collecting and Storing Tissue From Young Patients With CancerCompletedNCT00898755
• Decision Making About Participating in Pharmacokinetic Studies in Patients Enrolled in a Phase I Treatment Clinical TrialCompletedNCT00890435
• Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to TreatmentWithdrawnNCT00458744Phase 1
• Vinblastine and Carboplatin in Treating Young Patients With Newly Diagnosed or Recurrent Low-Grade GliomaCompletedNCT00352495Phase 1
• Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid TumorsCompletedNCT00138216Phase 1
• Topotecan, G-CSF, and Radiation Therapy in Treating Young Patients With Newly Diagnosed Brain Stem GliomaTerminatedNCT00107471Phase 1/2
• Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS TumorsCompletedNCT00107458Phase 1
• High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade GliomasCompletedNCT00078988Phase 3
• Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin LymphomaCompletedNCT00040911Not applicable
• Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine GliomaCompletedNCT00028795Phase 2
• Temozolomide Plus Lomustine Followed by Radiation Therapy in Treating Patients With High-Grade Malignant GliomaCompletedNCT00006024Phase 1
• Radiation Therapy Plus Carboplatin and Lobradimil in Treating Children With Newly Diagnosed Brain Stem GliomasCompletedNCT00005602Phase 1
• Combination Chemotherapy Plus Radiation Therapy in Treating Children With Newly Diagnosed Brain Stem GliomaCompletedNCT00003935Phase 1
• Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal TumorsCompletedNCT00003846Phase 2
• Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Brain Stem GliomaCompletedNCT00003625Phase 1
• Etoposide Plus Radiation Therapy Followed by Combination Chemotherapy in Treating Children With Newly Diagnosed Advanced MedulloblastomaCompletedNCT00003573Phase 2
• Vinorelbine in Treating Children With Recurrent or Refractory CancersCompletedNCT00003234Phase 2
• Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal TumorsCompletedNCT00003203Phase 2
• Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord TumorsCompletedNCT00003141Phase 1
• Gene Testing to Help in the Diagnosis and Treatment of Childhood Brain TumorsCompletedNCT00003096
• Combination Chemotherapy in Treating Children With Progressive Brain TumorsCompletedNCT00002944Phase 3
• Radiation Therapy Plus Combination Chemotherapy in Treating Children With MedulloblastomaCompletedNCT00002875Phase 3
• Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell TumorsCompletedNCT00002594Phase 2
• Development of Strategies to Increase Enrollment in Clinical Trials for Children With CancerCompletedNCT00002485