Bristol-Myers Squibb: Cardiomyopathy, Hypertrophic trials

The registry lists 27 Cardiomyopathy, Hypertrophic studies with Bristol-Myers Squibb as lead sponsor. 9 are open to participants now and 8 have results posted.

Phase 1 1Phase 2 5Phase 3 6Phase 4 1No phase 15(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Evaluation of Mavacamten-Based Practice in Chinese Adults With Obstructive Hypertrophic CardiomyopathyNot yet recruitingNCT07846059
• Mavacamten Outcomes in Hypertrophic Cardiomyopathy (HCM) and the Associated Patient and Physician Experiences in the USRecruitingNCT07557498
• Effectiveness and Treatment Patterns of Mavacamten in Patients With Obstructive Hypertrophic Cardiomyopathy in Japan (MANAGE-HCM)RecruitingNCT07541833
• Mavacamten Post-marketing Surveillance in Patients With Obstructive Hypertrophic Cardiomyopathy in JapanRecruitingNCT07383025
• A Study to Assess the Real-World Effectiveness of Mavacamten in Adult Patients With Obstructive Hypertrophic Cardiomyopathy in ChinaRecruitingNCT07361289
• Real-world Patient Reported Outcomes Among Patients Treated With CamzyosRecruitingNCT06551129
• A Study to Assess the Safety of Mavacamten in Korean Patients With Symptomatic Obstructive Hypertrophic CardiomyopathyRecruitingNCT06146660
• Mavacamten Pregnancy Surveillance ProgramRecruitingNCT05939700
• A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)RecruitingNCT05489705
• A Study of Mavacamten in Non-Obstructive Hypertrophic CardiomyopathyTerminatedNCT05582395Phase 3Results posted
• A Study to Evaluate the Efficacy, Safety, and Tolerability of MYK-224 in Participants With Symptomatic Obstructive Hypertrophic CardiomyopathyTerminatedNCT05556343Phase 2Results posted
• A Study of Mavacamten in Obstructive Hypertrophic CardiomyopathyCompletedNCT05414175Phase 3Results posted
• A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction TherapyCompletedNCT04349072Phase 3Results posted
• Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEERCompletedNCT03496168Phase 2Results posted
• Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic CardiomyopathyCompletedNCT03470545Phase 3Results posted
• A Phase 2 Study of Mavacamten in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)CompletedNCT03442764Phase 2Results posted
• A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract ObstructionCompletedNCT02842242Phase 2Results posted
• Mavacamten in Obstructive Hypertrophic CardiomyopathyCompletedNCT07168655
• A Study to Assess the Treatment of Obstructive Hypertrophic Cardiomyopathy (oHCM) With Mavacamten in the USActive, not recruitingNCT07107373
• A Retrospective Cohort Study of Mavacamten Patient Support Program in CanadaCompletedNCT06549608
• COLLIGO-HCM: A Multinational Observational Study of the Real-World Effectiveness of Mavacamten Among Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM)Active, not recruitingNCT06372457
• Real-World Effectiveness of Mavacamten in CanadaCompletedNCT06338202
• A Study to Evaluate Mavacamten in Adolescents With Symptomatic Obstructive Hypertrophic CardiomyopathyActive, not recruitingNCT06253221Phase 3
• A Study to Assess Health-Related Quality of Life in Patients With Hypertrophic Cardiomyopathy in JapanCompletedNCT06181617
• A Study to Evaluate Mavacamten Impact on Myocardial Structure in Participants With Symptomatic Obstructive Hypertrophic CardiomyopathyActive, not recruitingNCT06112743Phase 4
• A Long-Term Safety Extension Study of Mavacamten in Adults Who Have Completed MAVERICK-HCM or EXPLORER-HCMCompletedNCT03723655Phase 2/3
• Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-461CompletedNCT02329184Phase 1