Assistance Publique - Hôpitaux de Paris: Anemia, Sickle Cell trials

The registry lists 49 Anemia, Sickle Cell studies with Assistance Publique - Hôpitaux de Paris as lead sponsor. 16 are open to participants now and 0 have results posted.

Phase 1 3Phase 2 8Phase 3 6Phase 4 2No phase 35(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Adaptive Platform Trial for Pain Management in Sickle Cell Vaso-Occlusive CrisisNot yet recruitingNCT07826988Phase 4
• Pleuropulmonary Ultrasound Imaging in Patients With Sickle Cell Disease in a Vaso-occlusive Crisis. "ECHODREP"Not yet recruitingNCT07782489
• Standard of Care Comparative Arm of Phase 1/2 Gene Therapy Trial DREPAMIR" in Severe Sickle Cell Disease PatientsNot yet recruitingNCT07752043Not applicable
• CPAP for Hypoxemic Acute Chest Syndrome in Sickle Cell DiseaseNot yet recruitingNCT07703566Not applicable
• Epidemiology of Invasive Bacterial Infections in Children With Sickle Cell Disease in France Between 2020 and 2025Not yet recruitingNCT07639008
• Efficacy Safety Study of Gene Therapy for Sickle Cell DiseaseSCD Using Autologous CD34+ Cells Transduced ex Vivo, Carrying a Corrected Globin Gene and a Silencing RNA.RecruitingNCT07432867Phase 1/2
• Long-term Endurance Training in Sickle Cell Disease Patients: Impact on Clinical Profile, Physical Fitness, and Quality of Life.RecruitingNCT06823219Not applicable
• Efficacy and Safety of Tocilizumab for Acute Chest Syndrome Treatment in Patients With Sickle Cell DiseaseRecruitingNCT06818266Phase 3
• Awake Prone Positioning for Severe Acute Chest SyndromeNot yet recruitingNCT06698120Not applicable
• Lung Ultrasound in Pediatric Acute Chest SyndromeRecruitingNCT06497153
• Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion ExplorationsRecruitingNCT06418256
• Comparative Health Status and Quality of Life of Patients With Sickle Cell Disease (SCD) Who Underwent Matched-sibling Hematopoietic Stem Cell Transplantation Versus Non Transplanted SCD Case-control PatientsNot yet recruitingNCT06351462Not applicable
• Early-goal Directed Automated Red Blood Cell Exchange for Acute Chest Syndrome in Sickle Cell DiseaseNot yet recruitingNCT06214845Not applicable
• Development of Non-Invasive Prenatal Diagnosis for Single Gene DisordersRecruitingNCT06147414
• Hemolysis Related Complications in SCD. A Phase II Study With VoxelotorRecruitingNCT05199766Phase 2
• High-flow Oxygen for Vaso-occlusive Pain CrisisRecruitingNCT03976180Not applicable
• Cohort Study of Sickle Cell Patients Evaluating Analgesic Strategies and Their ConsequencesCompletedNCT06650059
• The Montreal Cognitive Assessment.Test in Adults With Sickle Cell DiseaseCompletedNCT05347043Not applicable
• Nasopharyngeal Bacterial Carriage and Antibiotic Resistance in Children With Sickle Cell Disease in Ile-De-FranceStatus unknownNCT05197205Not applicable
• Severe Acute Respiratory Syndrome CoV 2 COVID-19 Survey and Vaccination Coverage in the Sickle Cell Population in Ile-De-FranceStatus unknownNCT05153044Not applicable
• Interest of Famotidine in Children With Sickle Cell DiseaseCompletedNCT05084521Phase 2/3
• Observational Prospective Study Measuring the Impact of the Use of a Hypnotic Script Associated With Virtual Reality on the Pain of the Child's Sickle Cell During a Vaso-occlusive CrisisCompletedNCT04917120Not applicable
• Prevalence and Pathophysiology of Systemic Arterial Pressure Abnormalities in Childhood Sickle Cell DiseaseStatus unknownNCT04911049
• Evaluation of Virtual Reality to Save Morphinic in the Treatment of Vaso-occlusive Seizures of Sickle Cell Patients Consulting in the Emergency RoomCompletedNCT04756375Not applicable
• Autonomic Nervous System and Sickle Cell DiseaseCompletedNCT04062409
• Comparison of Allogeneic Matched Related Haematopoietic Stem Cell Transplantation After a Reduced Intensity Conditioning Regimen With Standard of Care in Adolescents and Adults With Severe Sickle Cell DiseaseStatus unknownNCT04046705Phase 3
• Safety and Efficacy of Gene Therapy of the Sickle Cell Disease by Transplantation of an Autologous CD34+ Enriched Cell Fraction That Contains CD34+ Cells Transduced ex Vivo With the GLOBE1 Lentiviral Vector Expressing the βAS3 Globin Gene in Patients With Sickle Cell Disease (DREPAGLOBE)CompletedNCT03964792Phase 1/2
• Combined Use of a Respiratory Broad Panel Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Hospitalized Sickle-cell Adults With Acute Chest Syndrome.CompletedNCT03919266Not applicable
• Music Therapy in Sickle Cell Disease Vaso-occlusive CrisisStatus unknownNCT03639805Not applicable
• Transillumination Device for Peripheral Intravenous Placement in Patients With Sickle Cell Disease (PERFID)CompletedNCT03477552Not applicable
• Quality of Care of Children With Sickle Cell Disease (SCD) Screened at Birth in FranceCompletedNCT03119922
• Oxygen Therapy and Pregnancy in Sickle Cell DiseaseCompletedNCT02813850Phase 3
• Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal EventsCompletedNCT02539771Not applicable
• Immunogenicity Study of an Anti-pneumococcal Vaccination Strategy in Patients With Sickle Cells DiseaseCompletedNCT02274415Phase 2
• Assessment of Tolerance of Mobilizing Peripheral Hematopoietic Stem Cells by Plerixafor in Sickle Cell PatientsCompletedNCT02212535Phase 1/2
• Multicenter Observational Study on Myocardial Iron Overload in 3 Multitransfused PopulationsCompletedNCT01911871
• Future of Spermatogenesis in Men With Sickle Cell Disease Medically TreatedCompletedNCT01609192Phase 4
• Sleep Respiratory Disorders Evaluation in Sickle Cell Disease ChildrenCompletedNCT01565954
• Non Invasive Positive Pressure Ventilation for Prevention of Acute Chest Syndrome in Sickle Cell DiseaseTerminatedNCT01501643Not applicable
• Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral VasculopathyCompletedNCT01340404Not applicable
• Albuminuria Reduction With Renin Angiotensin System Inhibitors in SCA PatientsCompletedNCT01195818Not applicable
• Angiotensin-converting Enzyme Inhibitors and Early Sickle Cell Renal Disease in ChildrenTerminatedNCT01096121Not applicable
• Nitric Oxide Therapy for Acute Chest Syndrome in Sickle Cell Disease ChildrenCompletedNCT01089439Phase 2
• Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic StrategyCompletedNCT00874172Not applicable
• Inflammatory Response to Hydroxyurea Therapy in Sickle Cell DiseaseCompletedNCT00784082
• Sickle Cell Disease and Endothelial Progenitor Cells (EPCs)CompletedNCT00783627
• Effect of Inhaled Nitric Oxide in Acute Chest Syndrome (INOSTA Study)CompletedNCT00748423Phase 2/3
• Evaluation of the Lung Capillary Blood Volume in Children With Sickle Cell DiseaseCompletedNCT00560261Phase 3
• Evaluation of the Prevalence of Pulmonary Hypertension in Adult Patients With Sickle Cell DiseaseStatus unknownNCT00434902