AbbVie: Constipation trials

The registry lists 10 Constipation studies with AbbVie as lead sponsor. 0 are open to participants now and 9 have results posted.

Phase 1 1Phase 2 3Phase 3 5Phase 4 1(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)CompletedNCT04026113Phase 3Results posted
• An Open-Label, Long-term Study to Assess the Immunogenicity of LINZESS® (Linaclotide) Administered Orally to Adult Participants With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic ConstipationCompletedNCT02590432Phase 4Results posted
• A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With ConstipationTerminatedNCT02559817Phase 2Results posted
• A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)CompletedNCT02559570Phase 2Results posted
• Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer PainCompletedNCT02270983Phase 2Results posted
• Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal BloatingCompletedNCT01642914Phase 3Results posted
• Trial of Linaclotide Administered to Patients With Irritable Bowel Syndrome With ConstipationCompletedNCT00948818Phase 3Results posted
• An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With ConstipationCompletedNCT00765999Phase 3Results posted
• Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic ConstipationCompletedNCT00765882Phase 3Results posted
• A Lactation Study in Women Who Are Breastfeeding or Pumping and Are Receiving Linaclotide TherapeuticallyCompletedNCT02220348Phase 1