Simlukafusp alfa clinical trials
Also written RO6874281.
- studies test it
- 5
- open now
- 0
- in phase 3
- 0
- first study started
- 2015
How each study uses simlukafusp alfa has had a first review. Readers can ask us to read every study one by one.Ask us to read each study
Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
5 studies that test it; most in 2017 (2)
| Year | Studies |
|---|---|
| 2015 | 1 |
| 2017 | 2 |
| 2018 | 1 |
| 2019 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 5 · Other 0
Often tested with
Tested in the same studies.
Gemcitabine (2) · Albumin-Bound Paclitaxel (1) · Paclitaxel (1) · Cobimetinib (1) · PEGPH20 (1) · Motixafortide (1) · Selicrelumab (1) · Bevacizumab (1)
Studies
Open first, then newest update. How each study uses simlukafusp alfa has had a first review, but it may not be perfect: check the study record before relying on it for anything important, and report a problem from its row. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 5
- A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)CompletedPhase 1/2Hoffmann-La RocheNCT03193190Written as RO6874281Report a problem
- A Study to Evaluate Safety and Therapeutic Activity of RO6874281 in Combination with Pembrolizumab, in Participants with Advanced or Metastatic MelanomaCompletedPhase 1Hoffmann-La RocheNCT03875079Written as RO6874281Report a problem
- Basket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants With Advanced and/or Metastatic Solid TumorsTerminatedPhase 2Hoffmann-La RocheNCT03386721Written as simlukafusp alfaReport a problem
- Study to Evaluate Safety, Pharmacokinetics and Therapeutic Activity of RO6874281 as a Combination Therapy in Participants With Unresectable Advanced and/or Metastatic Renal Cell Carcinoma (RCC)CompletedPhase 1Hoffmann-La RocheNCT03063762Written as RO6874281Report a problem
- A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)CompletedPhase 1Hoffmann-La RocheNCT02627274Written as RO6874281Report a problem
Tested with established drugs · 3 — they are given beside it
- A Study to Evaluate Safety and Therapeutic Activity of RO6874281 in Combination with Pembrolizumab, in Participants with Advanced or Metastatic MelanomaCompletedPhase 1Hoffmann-La RocheNCT03875079Written as RO6874281Report a problem
- Study to Evaluate Safety, Pharmacokinetics and Therapeutic Activity of RO6874281 as a Combination Therapy in Participants With Unresectable Advanced and/or Metastatic Renal Cell Carcinoma (RCC)CompletedPhase 1Hoffmann-La RocheNCT03063762Written as RO6874281Report a problem
- A Study Evaluating Safety, Pharmacokinetics, and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)CompletedPhase 1Hoffmann-La RocheNCT02627274Written as RO6874281Report a problem
Tested in a combination · 2 — another drug in the study is under test too
- A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)CompletedPhase 1/2Hoffmann-La RocheNCT03193190Written as RO6874281Report a problem
- Basket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants With Advanced and/or Metastatic Solid TumorsTerminatedPhase 2Hoffmann-La RocheNCT03386721Written as simlukafusp alfaReport a problem
Given beside what is tested · 1 — usual care or a partner of the new treatment
Codes
What other systems call simlukafusp alfa · ClinicalTrials.gg INT016571
- UNII (FDA) FL08SGO9XASIMLUKAFUSP ALFAOne source FDA
- NCI Thesaurus C129383Simlukafusp AlfaOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | FL08SGO9XA | SIMLUKAFUSP ALFA | One source FDA |
| NCI Thesaurus | C129383 | Simlukafusp Alfa | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.