Simendan: all 75 studies that test it

Page 1 of 1. Open to participants first (5), then studies with results posted, then the rest; newest registration first within each.

• Levosimendan in Acute Decompensated Heart FailureNot yet recruitingNCT07262723Phase 2/3
• Shorter Weaning From Invasive Ventilation With LevosimendanRecruitingNCT07105202Phase 4
• RCT Study of Levosimendan Improving Prognosis of Cardiac ArrestNot yet recruitingNCT05956431Phase 4
• Using TEE to Evaluate the Effect of Levosimendan on Patients With ARDS Associated With RVD During MVNot yet recruitingNCT05768230Phase 2/3
• Effect of Early Use of Levosimendan Versus Placebo on Top of a Conventional Strategy of Inotrope Use on a Combined Morbidity-mortality Endpoint in Patients With Cardiogenic ShockRecruitingNCT04020263Phase 3
• Effects of Oral Levosimendan on Respiratory Function in Patients With Amyotrophic Lateral Sclerosis (ALS): Open-Label ExtensionTerminatedNCT03948178Phase 3Results posted
• Open-Label Rollover Study of Levosimendan in PH-HFpEF PatientsCompletedNCT03624010Phase 2Results posted
• Hemodynamic Evaluation of Levosimendan in Patients With PH-HFpEFCompletedNCT03541603Phase 2Results posted
• Effects of Oral Levosimendan (ODM-109) on Respiratory Function in Patients With ALSCompletedNCT03505021Phase 3Results posted
• Levosimendan Efficacy Assessment by Cardiopulmonary Exercise Test (CPET)CompletedNCT02261948Phase 4Results posted
• Is Levosimendan Superior to Milrinone Regarding Acute Kidney Injury After Cardiac Surgery for Congenital Heart Disease?CompletedNCT02232399Phase 2Results posted
• Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary BypassCompletedNCT02025621Phase 3Results posted
• Effects of Levosimendan in Patients Eligible for Aortic Valve Replacement With Left Ventricular HypertrophyTerminatedNCT01188369Phase 4Results posted
• Myocardial Hemodynamic Effects of LevosimendanCompletedNCT00585104Phase 2Results posted
• Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal FunctionCompletedNCT07186062Phase 4
• Levosimendan as Treatment of Aneurysmal SubArachnoid HaemorrhageCompletedNCT05664191Phase 2
• Levosimendan Versus Placebo Before Tricuspid Valve Surgery in Patients With Right Ventricular DysfunctionStatus unknownNCT05233202Phase 3
• Levosimendan in Patients With Impaired Right Ventricular Function Undergoing Cardiac SurgeryStatus unknownNCT05063370Phase 2
• Effect of Levosimendan on Left Ventricular Systolic Function and Heart Failure After PCI in Patients With Acute Anterior Myocardial InfarctionStatus unknownNCT04970238Phase 4
• Effect of Levosimendan on miRNAs Regulation in the Failing HeartsStatus unknownNCT04950569Phase 4
• LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock PatientsCompletedNCT04728932Phase 3
• Levosimendan In Ambulatory Heart Failure PatientsTerminatedNCT04705337Phase 4
• The Effectiveness and Safety of Levosimendan in Patients With Severe Aortic Stenosis and Heart Failure Undergoing Transcatheter Aortic Valve ReplacementStatus unknownNCT04573049Phase 4
• Levosimendan Versus Combination With Magnesium Sulphate on Spine Protection by NIRS in Infants Undergoing CoarctectomyCompletedNCT04330755Phase 4
• Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk PatientsCompletedNCT04329624Phase 3
• Spanish Randomized Clinical Trial to Compare Levosimendan Versus Placebo in Postoperative Cardiac Surgery (SPARTANS)Status unknownNCT04179604Phase 2/3
• Interest of Levosimendan in Reducing Weaning Failures of ExtraCorporeal Life Support - ECLSTerminatedNCT04158674Phase 3
• Levosimendan Versus Milrinone in Off Pump CABG SurgeryStatus unknownNCT03855579Phase 4
• Effectiveness of a Repetitive Use of 24-hour Levosimendan Infusions in Patients With Severe Systolic Heart Failure in Order to Prevent RehospitalizationsStatus unknownNCT03764722Phase 4
• Clinical Trial in Patients Who Have Suffered a Heart Attack and Who Have Undergone Catheterization Treated With LevosimendanStatus unknownNCT03699215Phase 3
• Effect of Levosimendan or Placebo on Exercise in Advanced Chronic Heart FailureStatus unknownNCT03576677Phase 4
• Levosimendan for Cardiac Patients Undergoing Major Abdominal Cancer SurgeriesCompletedNCT03557255Phase 2
• Evaluate the Efficacy and Safety of Short-term Administration of SIMDAXStatus unknownNCT03555123Phase 3
• Repetitive Levosimendan Infusion for Patients With Advanced Chronic Heart FailureStatus unknownNCT03437226Phase 3
• Acute and Chronic Protective Effects of Peri-interventional Administration of Levosimendan in ST Elevation Myocardial InfarctionsWithdrawnNCT03022877Not applicable
• Effects of Levosimendan on Cellular Metabolic Alterations in Patients With Septic ShockStatus unknownNCT02963454Not applicable
• Effects of Levosimendan, Milrinone and Norepinephrine on Left and Right Ventricular Function in Septic ShockStatus unknownNCT02640846Phase 4
• Effects of Levosimendan in Acute Kidney Injury After Cardiac SurgeryCompletedNCT02531724Phase 4
• Effects of ODM-109 on Respiratory Function in Patients With Amyotrophic Lateral SclerosisCompletedNCT02487407Phase 2
• Changes in Cardiac Deformation Following Physiologic Alterations and Inotropic Support.CompletedNCT02408003Not applicable
• Preoperative Levosimendan in CABG Patients With Poor LV FunctionCompletedNCT02184819Phase 3
• Levosimendan Versus Dobutamine for Renal Function in Heart FailureCompletedNCT02133105Phase 3
• Levosimendan Versus Dobutamine in Cardiopatic Patients Undergoing Major Non Cardiac SurgeryStatus unknownNCT02012946Phase 4
• The Effects of Levosimendan During Mitral Valve SurgeryCompletedNCT01969071Phase 4
• Effects of Levosimendan on Diaphragm Function in Mechanically Ventilated PatientsStatus unknownNCT01721434Phase 2/3
• Levosimendan in Acute Kidney Injury StudyCompletedNCT01720030Phase 2/3
• Assessment of Hemodynamic Response in Cardiopulmonary Bypass Graft After Cardiopulmonary Bypass Using Transesophegeal EchocardiographyCompletedNCT01616069Phase 4
• Comparison of the Administration of Levosimendan and Placebo in the Preparation of Critical Patients for Heart SurgeryCompletedNCT01595737Phase 4
• Two Inodilators Postsurgery in NeonatesCompletedNCT01576094Phase 1/2
• Intermittent Intravenous Levosimendan in Ambulatory Advanced Chronic Heart Failure PatientsCompletedNCT01536132Phase 4
• Intracoronary Administration of Levosimendan in Cardiac Surgery PatientsTerminatedNCT01500785Phase 4
• Prophylactic Administration of Levosimendan in Patients Undergoing Coronary SurgeryCompletedNCT01318460Phase 4
• Efficacy and Safety of Levosimendan in Severe Acute Heart Failure in Critical ChildrenTerminatedNCT01301313Phase 2
• ELEVATE Early LEvosimendan Vs Usual Care in Advanced Chronic hearT failurETerminatedNCT01290146Phase 3
• The Effects of Levosimendan on Haemodynamics in Patients Undergoing Elective Aortic Valve Replacement (AVR)Together With Coronary Artery Bypass Grafting (CABG) SurgeryCompletedNCT01210976Phase 4
• Levosimendan Administration in Neonates With Transposition of the Great ArteriesCompletedNCT01120106Phase 2
• Effect of Levosimendan on Respiratory Muscle Function in Healthy SubjectsCompletedNCT01101620Not applicable
• Efficacy and Safety of Pulsed Infusions of Levosimendan in Outpatients With Advanced Heart FailureStatus unknownNCT01065194Phase 3
• Preoperative Levosimendan and Heart FailureWithdrawnNCT01022983Phase 4
• Levosimendan in High Risk Patients Undergoing Cardiac SurgeryCompletedNCT00994825Phase 4
• Long-Term Intermittent Administration of Levosimendan in Patients With Advanced Heart FailureStatus unknownNCT00988806Phase 4
• Effects of Levosimendan on Microcirculation in Septic ShockCompletedNCT00800306Phase 2
• Effects of Oral Levosimendan on Ambulatory Electrocardiographic VariablesCompletedNCT00698763Phase 2
• Levosimendan in Congenital Cardiac SurgeryCompletedNCT00695929Not applicable
• Levosimendan and Myocardial ProtectionCompletedNCT00610350Phase 4
• Prophylactic Use of Levosimendan Versus Milrinone in Open Heart Surgery in InfantsStatus unknownNCT00549107Phase 2
• Survival of Patients With Acute Heart Failure in Need of Intravenous Inotropic Support: a Multicentre, Parallel-Group, Randomised, Double-Blind, Double-Dummy Study of Levosimendan Versus Dobutamine in Patients With Acute Heart Failure.CompletedNCT00348504Phase 3
• Levosimendan in Acute Heart Failure Following Acute Myocardial Infarction.CompletedNCT00324766Phase 4
• Efficacy and Safety of Treatment With Simdax® Versus Dobutrex® in Decompensated Heart Failure Patients.CompletedNCT00219388Phase 4
• Study of Blood Concentrations and Physiologic Effects of Levosimendan Given During Heart SurgeryTerminatedNCT00166127Phase 3
• Levosimendan in High Risk Heart Valve SurgeryCompletedNCT00154115Phase 4
• Peroral Levosimendan in Chronic Heart FailureCompletedNCT00130884Phase 2
• Levosimendan Pretreatment for Weaning Patients From Cardio-Pulmonary BypassCompletedNCT00130871Phase 2
• Levosimendan Versus Dobutamine in Shock PatientsStatus unknownNCT00093301Phase 2/3
• Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure.CompletedNCT00048425Phase 3

← Simendan overview