Sacubitril valsartan: all 91 studies that test it
Page 1 of 1. Open to participants first (7), then studies with results posted, then the rest; newest registration first within each.
- Pulmonary REsistance Modification Under Treatment With Sacubitril/valsartaN in paTients With Heart Failure With Reduced Ejection FractionRecruitingNCT05487261Phase 4
- Sacubitril/Valsartan in PriMAry preventIoN of the Cardiotoxicity of Systematic breaST canceR trEAtMent (MAINSTREAM)RecruitingNCT05465031Phase 4
- Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/ValsartanRecruitingNCT05194111Phase 1/2
- PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm AxisRecruitingNCT04971720Phase 2/3
- The Effects of Sacubitril-Valsartan vs Enalapril on Left Ventricular Remodeling in ST-elevation Myocardial InfarctionNot yet recruitingNCT04912167Phase 3
- Angiotensin Receptor-Neprilysin Inhibition in Chagas Cardiomyopathy With Reduced Ejection Fraction: ANSWER-HF.RecruitingNCT04853758Phase 3
- Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) StudyRecruitingNCT04191681Phase 4
- Protecting With ARNI Against Cardiac Consequences of Coronavirus Disease 2019CompletedNCT04883528Phase 1/2Results posted
- Effective Study of ARNI on Ventricular Arrhythmia in HFrEF Patients With ICD or CRT-D (RHYTHM)TerminatedNCT04491136Phase 4Results posted
- Study of Efficacy of Oral Sacubitril/Valsartan in Adult Patients With Non-obstructive Hypertrophic CardiomyopathyCompletedNCT04164732Phase 2Results posted
- The ENCHANTMENT HIV StudyCompletedNCT04153136Phase 2Results posted
- Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 2CompletedNCT04113109Phase 4Results posted
- COmparing arNi and Ace For Improving Erectile Dysfunction in mEN With reduCed Ejection Fraction Heart FailureCompletedNCT03917459Phase 3Results posted
- An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan.TerminatedNCT03909295Phase 3Results posted
- Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1TerminatedNCT03738878Phase 4Results posted
- Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection FractionCompletedNCT03506412Phase 4Results posted
- Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MICompletedNCT02924727Phase 3Results posted
- randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart FailureCompletedNCT02900378Phase 3Results posted
- Effects of Sacubitril/Valsartan Therapy on Biomarkers, Myocardial Remodeling and Outcomes.CompletedNCT02887183Phase 4Results posted
- Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection FractionCompletedNCT02884206Phase 3Results posted
- Study of Effects of Sacubitril/Valsartan vs. Enalapril on Aortic Stiffness in Patients With Mild to Moderate HF With Reduced Ejection FractionCompletedNCT02874794Phase 4Results posted
- EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study)CompletedNCT02816736Phase 4Results posted
- Exercise Capacity Study of LCZ696 vs. Enalapril in Patients With Chronic Heart Failure and Reduced Ejection Fraction.CompletedNCT02768298Phase 4Results posted
- Demonstration of Reverse Remodeling Effects of Entresto. Using Echocardiography Endocardial Surface AnalysisCompletedNCT02754518Phase 4Results posted
- Description of Tolerability of LCZ696 (Sacubitril / Valsartan) in Heart Failure With Reduced Ejection Fraction (HFrEF) Treated in Real Life SettingCompletedNCT02690974Phase 4Results posted
- Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart FailureCompletedNCT02678312Phase 2/3Results posted
- Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation EventCompletedNCT02661217Phase 4Results posted
- Use of Entresto Sacubitril/Valsartan for the Treatment of Peripheral Arterial DiseaseTerminatedNCT02636283Phase 2Results posted
- Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode.CompletedNCT02554890Phase 4Results posted
- Study of Efficacy and Safety of LCZ696 in Japanese Patients With Chronic Heart Failure and Reduced Ejection FractionCompletedNCT02468232Phase 3Results posted
- Safety and Tolerability During Open-label Treatment With LCZ696 in Patients With CHF and Reduced Ejection FractionCompletedNCT02226120Phase 3Results posted
- Safety and Tolerability of Initiating LCZ696 in Heart Failure PatientsCompletedNCT01922089Phase 2Results posted
- Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection FractionCompletedNCT01920711Phase 3Results posted
- Efficacy and Safety of LCZ696 Compared to Olmesartan in Essential Hypertensive Patients Not Responsive to OlmesartanCompletedNCT01876368Phase 3Results posted
- A Study to Evaluate the Effect of LCZ696 on Aortic Stiffness in Subjects With HypertensionCompletedNCT01870739Phase 2Results posted
- Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Asian Patients With Essential HypertensionCompletedNCT01785472Phase 3Results posted
- Study of the Safety and Efficacy of LCZ696 on Arterial Stiffness in Elderly Patients With HypertensionCompletedNCT01692301Phase 2Results posted
- Assessment of LCZ696 and Valsartan in Asian Patients With Salt-sensitive HypertensionCompletedNCT01681576Phase 2Results posted
- Efficacy and Safety of LCZ696 200 mg + Amlodipine 5 mg in Comparison With Amlodipine 5 mg in Hypertensive Patients Not Responding to AmlodipineCompletedNCT01663233Phase 3Results posted
- Safety and Tolerability and Efficacy of LCZ696 in Japanese Severe Hypertensive PatientsCompletedNCT01646671Phase 3Results posted
- Evaluation of the Metabolic Effects of LCZ696 and Amlodipine in Obese Hypertensive SubjectsCompletedNCT01631864Phase 2Results posted
- A Study of LCZ696 in Subjects With Mild and Moderate Hepatic Impairment Compared With Normal Healthy VolunteersCompletedNCT01621633Phase 2Results posted
- Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Elderly Patients With Essential HypertensionCompletedNCT01615198Phase 3Results posted
- Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate HypertensionCompletedNCT01601470Phase 2Results posted
- Efficacy and Safety of LCZ696 in Comparison to Olmesartan in Japanese Patients With Essential HypertensionCompletedNCT01599104Phase 3Results posted
- Safety and Tolerability and Efficacy of LCZ696 in Japanese Hypertensive Patients With Renal DysfunctionCompletedNCT01593787Phase 3Results posted
- Pharmacokinetics of LCZ696 in Subjects With Mild and Moderate Renal Impairment Compared to Healthy Subjects With Normal Renal FunctionCompletedNCT01569815Phase 1Results posted
- Sodium Excretion of LCZ696 in Patients With Hypertension; Heart Failure and Healthy VolunteersCompletedNCT01353508Phase 2Results posted
- An 8-week Study to Evaluate the Dose Response of AHU377 in Combination With Valsartan 320 mg in Patients With Mild-to-moderate Systolic HypertensionCompletedNCT01281306Phase 2Results posted
- A Long-term (12 Months) Safety, Tolerability and Efficacy Study of LCZ696 in Patients With Essential HypertensionCompletedNCT01256411Phase 2Results posted
- Efficacy and Safety of LCZ696 Compared to Placebo in Patients With Essential HypertensionCompletedNCT01193101Phase 2Results posted
- This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart FailureTerminatedNCT01035255Phase 3Results posted
- LCZ696 Compared to Valsartan in Patients With Chronic Heart Failure and Preserved Left-ventricular Ejection FractionCompletedNCT00887588Phase 2Results posted
- Efficacy and Safety of LCZ696A in Patients With Essential HypertensionCompletedNCT00549770Phase 2Results posted
- Effect of Sacubitril-Valsartan on Estimated Pulmonary Artery Systolic Pressure in Patients With Heart Failure With Reduced Ejection Fraction Heart FailureCompletedNCT07814482Phase 1
- Sacubitril-valsartan in Patients With Heart Failure.CompletedNCT07341893Not applicable
- Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection FractionWithdrawnNCT06536309Phase 4
- Detoxification From the Lipid TractCompletedNCT06357104Phase 4
- Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve RegurgitationCompletedNCT05991284Phase 4
- " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fraction in ACHD "Status unknownNCT05580510Phase 2/3
- Sacubitril Valsartan in Preventing the Recurrence of Atrial Fibrillation After Ablation in Elderly Hypertensive Patients With Atrial FibrillationCompletedNCT05528419Phase 4
- Angiotensin-Neprilysin Inhibition in Hemodialysis InitiationCompletedNCT05498181Phase 2
- Open Label RCT for Chronic Severe AR : Entresto vs. CCB/ARBStatus unknownNCT05212597Phase 2
- Program of Angiotensin-Neprilysin Inhibition in Admitted Patients With Worsening Heart Failure (PREMIER)Active, not recruitingNCT05164653Phase 4
- Roxadustat Combined With Sacubitril Valsartan Sodium Tablets in the Treatment of Cardiorenal Anemia SyndromeStatus unknownNCT05053893Not applicable
- Treatment of PH With Angiotensin II Receptor Blocker and Neprilysin Inhibitor in HFpEF Patients With CardioMEMS DeviceCompletedNCT04753112Phase 3
- The Bio-Clinical Effects of the (Sacubitril-Valsartan) Combination on Patients With Chronic Heart FailureCompletedNCT04688294Phase 4
- Personalised Prospective Comparison of ARni With ArB in Patients With Natriuretic Peptide eLEvationStatus unknownNCT04687111Phase 2
- Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3CompletedNCT04649229Phase 4
- Sacubitril/Valsartan in Resistant HypertensionCompletedNCT04637152Phase 2
- Efficacy and Safety of Sacubitril/Valsartan in Maintenance Hemodialysis Patients With Heart FailureStatus unknownNCT04458285Not applicable
- Comparison of ARNI to Alternate Oral Vasodilator Therapies in Patients With Low Cardiac OutputWithdrawnNCT04206865Phase 4
- Study of Sacubitril/ValsarTan on MyocardIal OxygenatioN and Fibrosis in Heart Failure With Preserved Ejection FractionWithdrawnNCT04128891Phase 3
- Sacubitril/Valsartan in Left Ventricular Assist Device RecipientsActive, not recruitingNCT04103554Phase 4
- Effect of Angiotensin Converting Enzyme and Sacubitril Valsartan in Patients After Bone Marrow TransplantationStatus unknownNCT04092309Not applicable
- The Renin-Angiotensin-Aldosterone System in Adiposity, Blood Pressure and Glucose in African AmericansActive, not recruitingNCT03938389Phase 4
- LCZ696 in Advanced LV Hypertrophy and HFpEFCompletedNCT03928158Phase 2
- Effect of Neprilysin on Glucagon-Like Peptide-1 in Patients With Type 2 DiabetesCompletedNCT03893526Phase 4
- The Role of Sacubitril/Valsartan in Post-acute Myocardial InfarctionCompletedNCT03893435Not applicable
- Effect of Angiotensin-Neprilysin Inhibition (ARNI) on Prognosis of Chronic Heart FailureStatus unknownNCT03821701Not applicable
- Effect of ARNI in Patients With Persistent AF and Enlarged Left Atrium After Catheter AblationStatus unknownNCT03791723Not applicable
- Observation on the Effect of Sacubitril/Valsartan in Advanced Chronic Kidney Disease（CKD）Patients With Heart FailureStatus unknownNCT03771729Early Phase 1
- PDD in Type 2 Diabetes w/wo Diastolic DysfunctionCompletedNCT03744975Phase 2
- The Effects of Neprilysin on Glucagon-like Peptide-1CompletedNCT03717688Phase 4
- Role of ARNi in Ventricular Remodeling in Hypertensive LVHCompletedNCT03553810Phase 2
- Sacubitril-valsartan Versus Usual Anti-hypertensives in LVADWithdrawnNCT03279861Phase 4
- Mechanism(s) Underlying Cardiovascular Effects of ARB/NEP Inhibition - Aim 2WithdrawnNCT03005184Phase 2
- Sacubitril-valsartan and Heart Failure Patients : the ENTRESTO-SAS StudyCompletedNCT02916160Phase 4
- Pharmacological Reduction of Functional, Ischemic Mitral REgurgitationCompletedNCT02687932Phase 4
- Study of the Efficacy and Safety of LCZ696 Alone and in Combination With Amlodipine in Patients With HypertensionWithdrawnNCT01865188Phase 3
- Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable Heart FailureCompletedNCT00913653Phase 2