Protein Kinase Inhibitors: all 15,280 studies that test it
Page 76 of 153. Open to participants first (2,558), then studies with results posted, then the rest; newest registration first within each.
- A Trial of YL-13027 in Combination With Gemcitabine and Nab-paclitaxel in Patients With Refractory Metastatic Pancreatic CancerTerminatedNCT06199466Phase 1
- A Study to Investigate BGB-3245 (Brimarafenib) With Panitumumab in Participants With Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal CancersTerminatedNCT06194877Phase 1
- To Evaluate the Efficacy/Safety of Osimertinib Prior to CRT and Maintenance of it With Stage III, Unresectable NSCLC With EGFR MutationsActive, not recruitingNCT06194448Phase 2
- Study of Zanzalintinib (XL092) + AB521 and Zanzalintinib + AB521 + Nivolumab in Participants With Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Other Advanced Solid Tumors (STELLAR-009)TerminatedNCT06191796Phase 1
- A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid TumorsActive, not recruitingNCT06188520Phase 1/2
- A Study to Investigate Safety, Tolerability, PK and Anti-tumor Activity of TRX-221 in EGFRm NSCLC PatientsTerminatedNCT06186076Phase 1/2
- Induction and Tapering Therapy With Tofacitinib and Glucocorticoid in Patients With Polymyalgia RheumaticaCompletedNCT06172361Phase 3
- A Phase I Study of NTQ1062 in Chinese Patients With Advanced Solid TumorsCompletedNCT06172309Phase 1
- caBozantinib in Pre-treated pAtients With Metastatic COlorectal Cancer.Active, not recruitingNCT06171854Phase 2
- A Clinical Trial of TQB3015 Tablets in Patients With Advanced Malignant CancerWithdrawnNCT06165809Phase 1
- A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With AchondroplasiaCompletedNCT06164951Phase 3
- A 52-Week Study to Learn About the Safety and Effects of Ritlecitinib in Participants With Nonsegmental VitiligoActive, not recruitingNCT06163326Phase 3
- A Study of Surufatinib as Adjuvant Therapy for Pancreatic Neuroendocrine TumorsTerminatedNCT06158516Phase 2
- Efficacy and Safety of Baricitinib in Oral Lichen Planus: a Proof-of-Concept StudyActive, not recruitingNCT06158113Phase 2
- Efficacy and Safety of Oral Tofacitinib in the Treatment of Alopecia AreataCompletedNCT06157905Early Phase 1
- An ADME Study of [14C]AZD4604 and the Absolute Bioavailability of AZD4604CompletedNCT06157255Phase 1
- Beamion LUNG-2: A Study to Test Whether Zongertinib (BI 1810631) Helps People With Advanced Non-small Cell Lung Cancer With HER2 Mutations Compared With Standard TreatmentActive, not recruitingNCT06151574Phase 3
- An Drug-drug Interaction Study to Evaluate the Effects of Omeprazole 40mg on the Pharmacokinetics of SPRYCEL®CompletedNCT06145217Phase 1
- A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.Active, not recruitingNCT06143891Phase 3
- A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-naïve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)Active, not recruitingNCT06140836Phase 3
- Lenvatinib After Progression on Atezolizumab-bevacizumab in Hepatocellular CarcinomaActive, not recruitingNCT06138769Phase 2
- A 44-week Monocentric Open Study Assessing the Efficacy and Safety of Deucravacitinib in Adults With Inflammatory GenodermatosesCompletedNCT06136403Phase 2
- A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the BrainActive, not recruitingNCT06132945Phase 1
- A Study of WX390 in Patients With Advanced Solid Tumors With PIK3CA MutationsCompletedNCT06132932Phase 1/2
- Gestational Treatment With Ursodeoxycholic Acid Compared to Placebo to Reduce Severity of Gestational Diabetes Mellitus Diagnosed at 24-28 Weeks' GestationCompletedNCT06127355Phase 3
- The Mass Balance Study of LP-168 in Healthy SubjectsCompletedNCT06126861Phase 1
- A Study of AB801 Monotherapy and Combination Therapy in Participants With Advanced MalignanciesCompletedNCT06120075Phase 1
- A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With VitiligoActive, not recruitingNCT06118411Phase 3
- A Clinical Trial of TQB2450 Injection Combined With AL2846 Capsules in Patients With Advanced Solid TumorsActive, not recruitingNCT06116240Phase 1
- Perioperative TORIPALIMAB Plus LENVATINIB in Patients With Renal Cell Carcinoma Undergoing Nephrectomy (PLUTO)TerminatedNCT06114940Phase 2
- A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V2)Active, not recruitingNCT06113471Phase 3
- A Study to Evaluate Efficacy and Safety of Povorcitinib in Participants With Nonsegmental Vitiligo (STOP-V1)Active, not recruitingNCT06113445Phase 3
- A Study of TAK-279 in Healthy Chinese AdultsCompletedNCT06111547Phase 1
- A Study of Lenvatinib, Pembrolizumab, and Fulvestrant in People With Breast CancerActive, not recruitingNCT06110793Phase 1/2
- Neratinib In Combination With Chemotherapy/Trastuzumab/Pembrolizumab In HER2 Gastroesophageal CancerActive, not recruitingNCT06109467Phase 2
- Neoadjuvant Camrelizumab With Dalpiciclib for Resectable Head and Neck Squamous Cell CarcinomasStatus unknownNCT06109207Phase 1
- A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 60 Weeks of Treatment With a Withdrawal and Retreatment PeriodCompletedNCT06108544Phase 3
- Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS MutationActive, not recruitingNCT06106308Phase 2
- Study of the Tolerability and Pharmacokinetics of Oral Doses of SAR442168 With a Food Effect Investigation in Healthy Adult ParticipantsCompletedNCT06106074Phase 1
- A Study to Learn About the Study Medicine Called PF-07220060 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of TreatmentActive, not recruitingNCT06105632Phase 2
- A Study of PLB1001 Enteric Capsules in the Treatment of sGBM/IDH Mutant Glioblastoma Patients With the ZM Fusion Gene (FUGEN).Active, not recruitingNCT06105619Phase 2/3
- A Study of Pirtobrutinib (LY3527727 [LOXO-305]) Versus Placebo in Participants With Relapsing Multiple SclerosisWithdrawnNCT06104683Phase 2
- A Study of Avutometinib for People With Solid Tumor CancersActive, not recruitingNCT06104488Phase 1
- A Study of [14C]-LOXO-783 in Healthy Adult ParticipantsCompletedNCT06102512Phase 1
- A Study of LNK01001 Capsule in Moderately to Severely Active Rheumatoid ArthritisCompletedNCT06099535Phase 2
- Study of EYP-1901 in Patients With Diabetic Macular Edema (DME)CompletedNCT06099184Phase 2
- A Trial to Study the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Dermatosis Papulosa Nigra (DPN)Active, not recruitingNCT06099080Phase 2
- Pilot Study on Trametinib for Surgical Unruptured AVMsWithdrawnNCT06098872Phase 2
- Regorafenib With Temozolomide With or Without RT in MGMT-Methylated, IDH Wild-type GBM PatientsCompletedNCT06095375Phase 1
- A Study of Vedolizumab With Tofacitinib in Adults With Ulcerative Colitis (UC)Active, not recruitingNCT06095128Phase 4
- Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met ProteinWithdrawnNCT06093503Phase 3
- Effect of Ursodeoxycholic Acid Supplementation on Liver Regeneration on Right Lobe Donor HepatectomyCompletedNCT06091787Not applicable
- A Study to Evaluate the Drug Levels, Metabolism, and Removal of BMS-986322 in Healthy Adult Male ParticipantsCompletedNCT06088264Phase 1
- A Study About How Well TAK-279 Works and Its Safety in Participants With Moderate-to-severe Plaque Psoriasis During 52 Weeks of TreatmentCompletedNCT06088043Phase 3
- Phase 2 Study to Evaluate the Efficacy of Regorafenib in Specific GIST Mutation Subsets (KIT Exon 17, 18, or 14 Mutation and SDHB Deficient GIST) in the Post-imatinib Second-line Setting.Active, not recruitingNCT06087263Phase 2
- A Study of LNK01001 Capsule in Patients With Ankylosing SpondylitisCompletedNCT06085534Phase 2
- A Study of LNK01001 Capsule in Patients With Moderate to Severe Atopic DermatitisCompletedNCT06085521Phase 2
- DZD9008 PK Study in Hepatic Impairment SubjectsCompletedNCT06084104Phase 1
- PhI/II Study of Amivantamab and Tepotinib Combo in MET-altered Non-small Cell Lung CancerActive, not recruitingNCT06083857Phase 1/2
- Neratinib and Trastuzumab Biosimilar in Patients with HER2 Mutated Advanced Solid CancersCompletedNCT06083662Phase 2
- TGRX-326 Chinese Phase III for Advanced Non-small Cell Lung Cancer (NSCLC)Active, not recruitingNCT06082635Phase 3
- Study of BEBT-908 in Subjects With Advanced Hematological TumorsCompletedNCT06082596Phase 1
- Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell CarcinomaActive, not recruitingNCT06082167Phase 2/3
- Sirolimus for Improving Social Abilities in People With PTEN Germline MutationsWithdrawnNCT06080165Phase 1/2
- Study of BEBT-908 in the Relapsed or Refractory Diffuse Large B-cell Lymphoma SubjectsCompletedNCT06074107Phase 2
- Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)Active, not recruitingNCT06073821Phase 3
- A 104-Week Study of Ritlecitinib Oral Capsules in Adults With Nonsegmental Vitiligo (Active and Stable) Tranquillo 2Active, not recruitingNCT06072183Phase 3
- AMG510 (sotorasib) Plus Lenvatinib As Second-line Treatment in Patients with KRASG12C Mutant, Metastatic NSCLCWithdrawnNCT06068153Phase 2
- Zanubrutinib in Primary Cold Agglutinin DiseaseActive, not recruitingNCT06067048Phase 2
- Study of TT-00420 (Tinengotinib) in Subjects With Cholangiocarcinoma Who Failed or Relapsed to Chemotherapy and FGFR InhibitorActive, not recruitingNCT06057571Phase 2
- Evaluation of DASATINIB Monotherapy Efficacy in Acute Myeloid Leukemia Patients Refractory to VENETOCLAX-AZACITIDINESuspendedNCT06055621Phase 2
- Belumosudil and Rituximab for Primary Treatment of Chronic Graft-Versus-Host-DiseaseSuspendedNCT06046248Phase 2
- Relative Bioavailability and Effect of Food Study With an Oral Mini-tablet Formulation of Filgotinib in Healthy SubjectsCompletedNCT06043739Phase 1
- Phase 3b Study to Assess the Efficacy, Safety, and Tolerability of Remibrutinib in Comparison to Placebo, With Omalizumab as Active Control, in Adult CSU Patients, Followed by an Open-label 52-week Optional Extension.Active, not recruitingNCT06042478Phase 3
- Study of Favezelimab Coformulated With Pembrolizumab (MK-4280A) in Participants With Selected Solid Tumors (MK-4280A-010)CompletedNCT06036836Phase 2
- Phase III Study of SY-5007, a RET Inhibitor, in Patients With Locally Advanced or Metastatic RET Fusion-positive NSCLCActive, not recruitingNCT06031558Phase 3
- Sorafenib In Egyptian Patients With Hepatocellular Carcinoma.CompletedNCT06030895Not applicable
- Study of Tilpisertib Fosmecarbil in Participants With Moderately to Severely Active Ulcerative ColitisActive, not recruitingNCT06029972Phase 2
- A Study to Evaluate the Effect of Food on LOXO-783 in Healthy ParticipantsCompletedNCT06028425Phase 1
- Phase II Trial of Trilaciclib, Pembrolizumab, Gemcitabine and Carboplatin in Metastatic Triple-Negative Breast CancerActive, not recruitingNCT06027268Phase 2
- A Study to Evaluate Drug-Drug Interaction of TQ05105 TabletsCompletedNCT06024915Phase 1
- Evaluating Rapamycin Treatment in Alzheimer's Disease Using Positron Emission TomographyCompletedNCT06022068Phase 1/2
- Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABACompletedNCT06020014Phase 2
- Osimertinib Combined With Aspirin Neoadjuvant Therapy for Resectable EGFR Mutated NSCLC Patients.Status unknownNCT06018688Phase 2
- Senolytics to Improve Osteoporosis TherapyCompletedNCT06018467Phase 2
- A Phase Ⅱ Study Assessing the Safety and Efficacy of PLB1004 in EGFR ex20ins Mutation Patients With Advanced and Metastatic Non-small Cell Lung Cancer(NSCLC)Active, not recruitingNCT06015503Phase 2
- Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung CarcinomaSuspendedNCT06014827Phase 2
- Effect of Food on the Pharmacokinetics of ORIC-114CompletedNCT06012721Phase 1
- A Study of Lorlatinib in Combination With Ramucirumab in People With Lung CancerActive, not recruitingNCT06007937Phase 1/2
- Regorafenib in Combination With Pembrolizumab or Pembrolizumab for MSI-H Colorectal CancerTerminatedNCT06006923Phase 2
- A Relative Bioavailability and Food Effect Study of TYRA-300-B01 Capsule and Tablet Formulations in Healthy Adult ParticipantsActive, not recruitingNCT06006702Phase 1
- A Study of REC-4881 in Participants With Cancers Which Have an AXIN1 or APC MutationTerminatedNCT06005974Phase 2
- A Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of AB801 in Healthy VolunteersCompletedNCT06004921Phase 1
- A Trial to Evaluate Efficacy, Safety, and Pharmacokinetics of Delgocitinib Cream in Chinese Adults and Adolescents With Moderate to Severe Chronic Hand EczemaCompletedNCT06004050Phase 3
- Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial TreatmentTerminatedNCT05999968Phase 1
- A Clinical Study of TQB3912 Tablets in Patients With Advanced Malignant TumorCompletedNCT05997342Phase 1
- Study of Ribociclib Administered Concurrently With Postoperative Radiation Therapy in Patients With High-Risk, HR+/HER2- Breast CancerActive, not recruitingNCT05996107Phase 1
- A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy AdultsCompletedNCT05995249Phase 1
- Study of Brexucabtagene Autoleucel Plus Dasatinib in Adults With Acute Lymphoblastic LeukemiaActive, not recruitingNCT05993949Phase 1
- A Study of TAK-279 in Adults With or Without Kidney ProblemsCompletedNCT05992155Phase 1