Protein Kinase Inhibitors: all 15,278 studies that test it
Page 118 of 153. Open to participants first (2,558), then studies with results posted, then the rest; newest registration first within each.
- Bioavailability Study of Sirolimus Tablets 2 mg Under Fasting ConditionCompletedNCT02296749Phase 1
- A Pharmacokinetics (PK) and Safety Study to Determine the Effect of Repeat Dosing of Trametinib on Combined Oral Contraceptive (Norethindrone Plus Ethinyl Estradiol) in Female Subjects With Solid TumorsWithdrawnNCT02292732Phase 1
- Study of Safety and Efficacy of LEE011 and Ceritinib in Patients With ALK-positive Non-small Cell Lung Cancer.CompletedNCT02292550Phase 1
- Duvelisib With Obinutuzumab in Patients With CLL/SLL Previously Treated With a BTKi (SYNCHRONY)TerminatedNCT02292225Phase 1
- Trametinib in Combination With Sorafenib in Patients With Advanced Hepatocellular CancerCompletedNCT02292173Phase 1
- Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid CancerWithdrawnNCT02289144Phase 2
- Sorafenib Concurrent With Yttrium-90 Transarterial Radioembolization in Patients With Advanced Hepatocellular CancerWithdrawnNCT02288507Phase 1
- Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have Completed Curative-Intent TreatmentWithdrawnNCT02287727Phase 2
- Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's TransformationWithdrawnNCT02285244Phase 2
- Clinical Trial to Evaluate the Safety and Effectiveness of GDC-0032 When Given Alongside TamoxifenCompletedNCT02285179Phase 1/2
- Icotinib as the Adjunctive Treatment After Surgery in Stage I-IIIB Lung Adenocarcinoma Patients With EGFR Gene MutationStatus unknownNCT02283424Phase 4
- Cetuximab + BYL719 + IMRT (Intensity-Modulated Radiation Therapy) in Stage III/IVB Head and Neck Squamous Cell Cancer (HNSCC)CompletedNCT02282371Phase 1
- Blood Detection of EGFR Mutation For Iressa TreatmentStatus unknownNCT02282267Not applicable
- Nilotinib in Cognitively Impaired Parkinson Disease Patients 001CompletedNCT02281474Phase 1
- Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG)TerminatedNCT02279576Phase 2
- A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051bCompletedNCT02279433Phase 1
- BIBF1120 in Patients With Advanced FGFR3 Mutated,Overexpressed,or Wild Type Urothelial CarcinomaStatus unknownNCT02278978Phase 2
- Combination of Icotinib and Gemcitabine as First-line Treatment in Pancreatic CancerStatus unknownNCT02278458Phase 1
- Study of WNT974 in Combination With LGX818 and Cetuximab in Patients With BRAF-mutant Metastatic Colorectal Cancer (mCRC) and Wnt Pathway MutationsCompletedNCT02278133Phase 1/2
- Personalized Adaptive Radiation Therapy With Individualized Systemic Targeted Therapy (PARTIST) for Locally Advanced, Non-small Cell Lung Cancer With Genomic Driver MutationsWithdrawnNCT02277457Early Phase 1
- Safety, Tolerability, Pharmacokinetics and Anti-tumour Activity of AC0010 in Advanced Non Small Cell Lung CancerStatus unknownNCT02274337Phase 1/2
- Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line TreatmentWithdrawnNCT02274012Phase 2
- Trial of AEB071 in Combination With BYL719 in Patients With MelanomaCompletedNCT02273219Phase 1
- Study of Chemotherapy Plus Icotinib to Treat EGFR Mutation-positive Non-small-cell Lung CancerStatus unknownNCT02272127Phase 2
- A Study to Evaluate the Effects of Ibrutinib on Cardiac Repolarization in Healthy ParticipantsCompletedNCT02271438Phase 1
- Crenolanib in Combination With Sorafenib in Patients With Refractory or Relapsed Hematologic MalignanciesCompletedNCT02270788Phase 1
- Study to Evaluate Safety and Activity of Crizotinib With Temozolomide and Radiotherapy in Newly Diagnosed GlioblastomaCompletedNCT02270034Phase 1
- Trial of PCI-32765 (BTK Inhibitor) in Combination With Carfilzomib in Relapse/Refractory Mantle Cell LymphomaTerminatedNCT02269085Phase 1
- Efficacy and Safety of Dacomitinib in the Treatment of Skin Squamous Cell CancerStatus unknownNCT02268747Phase 2
- Dovitinib in Combination With Imatinib in Patients With Gastrointestinal Stromal TumorsWithdrawnNCT02268435Phase 1
- Treatment-free Remission Accomplished With Dasatinib in Patients With CMLStatus unknownNCT02268370Phase 2
- Phase Ib/II Study of Sulfatinib in Treating Advanced Neuroendocrine TumorsCompletedNCT02267967Phase 1
- Safety and Tolerability of ODM-203 in Subjects With Advanced Solid TumoursCompletedNCT02264418Phase 1
- Intermittent LGX818 and MEK162 in Treating Patients With Metastatic Melanoma Who Have BRAFV600 MutationsWithdrawnNCT02263898Phase 2
- The Tolerability and Effects of AZD0530 in Individuals With or Without a Family History of AlcoholismCompletedNCT02262026Phase 1
- Phase II Study on Axitinib in Advanced Solitary Fibrous TumorCompletedNCT02261207Phase 2
- Phase I, Dose Study to Look at the Safety and Pharmacokinetics of AZD8835 in Patients With Advanced Solid TumoursCompletedNCT02260661Phase 1
- Efficiency of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)CompletedNCT02260505Phase 3
- Sorafenib Plus Vitamin K1 Versus Sorafenib in Advanced Hepatocellular CarcinomaCompletedNCT02259647Not applicable
- Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in PhaseTerminatedNCT02258607Phase 1
- Safety, Pharmacodynamics, Pharmacokinetics, and Efficacy of GS-9901 in Adults With Relapsed or Refractory Follicular Lymphoma, Marginal Zone Lymphoma, Chronic Lymphocytic Leukemia, or Small Lymphocytic LymphomaTerminatedNCT02258555Phase 1
- Study of Itacitinib in Combination With Docetaxel in Subjects With Non-Small Cell Lung CancerTerminatedNCT02257619Phase 2
- Everolimus and Brentuximab Vedotin in Treating Patients With Relapsed or Refractory Hodgkin LymphomaTerminatedNCT02254239Phase 1
- COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma PatientsCompletedNCT02253420Phase 1
- Safety and Tolerability of Combined Treatment With Nilotinib and Ruxolitinib in CML and Ph+ ALL PatientsCompletedNCT02253277Phase 1
- A Study of Safety and Pharmacokinetics of Volitinib With Docetaxel in Patients With Advanced Gastric CancerCompletedNCT02252913Phase 1
- Open-Label, Non Randomized Phase 2 Study With Safety Run-InCompletedNCT02249429Phase 2
- Patient Preference for Everolimus in Combination With Exemestane or Capecitabine in Combination With BevacizumabCompletedNCT02248571Phase 4
- Everolimus and Temozolomide in Advanced Gastroenteropancreatic Neuroendocrine Carcinoma (G3)CompletedNCT02248012Phase 2
- Momelotinib Combined With Capecitabine and Oxaliplatin in Adults With Relapsed/Refractory Metastatic Pancreatic Ductal AdenocarcinomaTerminatedNCT02244489Phase 1
- Everolimus and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory Hematologic CancerCompletedNCT02240719Phase 1
- A Study of LY2157299 in Participants With Unresectable Hepatocellular Cancer (HCC)CompletedNCT02240433Phase 1
- Study of Afuresertib Combined With Paclitaxel in Gastric CancerCompletedNCT02240212Phase 1
- HGG-TCP (High Grade Glioma - Tumor Concentrations of Protein Kinase Inhibitors)Status unknownNCT02239952Not applicable
- A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid LeukemiaCompletedNCT02236013Phase 1
- A Study Conducted in Subjects With Relapsed/Refractory Multiple Myeloma (MM); to Determine Dose of Afuresertib in Combination With Carfilzomib (Part 1) and to Investigate the Safety, Pharmacokinetic and Clinical Activity of the Combination Compared With Carfilzomib Alone (Part 2)TerminatedNCT02235740Phase 1
- Efficacy and Safety of XG-102 in Reduction of Post-cataract Surgery Intraocular InflammationCompletedNCT02235272Phase 3
- Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) EradicationStatus unknownNCT02233049Phase 2
- A Study of BBI503 in Adult Patients With Advanced Urologic MalignanciesWithdrawnNCT02232646Phase 2
- A Study of BBI503 in Adult Patients With Advanced Hepatobiliary CancerCompletedNCT02232633Phase 2
- A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal TumorsTerminatedNCT02232620Phase 2
- Phase 2 Study to Assess Activity & Safety of Front-line Ibrutinib + Rituximab in Unfit Chronic Lymphocytic LeukemiaCompletedNCT02232386Phase 2
- Dabrafenib and Trametinib Before and After Surgery in Treating Patients With Stage IIIB-C Melanoma With BRAF V600 MutationActive, not recruitingNCT02231775Phase 2
- Lapatinib Plus Trametinib in KRAS Mutant NSCLCCompletedNCT02230553Phase 1/2
- Early Phase Evaluation of ABC294640 in Patients With Refractory/Relapsed Diffuse Large B-cell Lymphoma or Kaposi SarcomaWithdrawnNCT02229981Phase 1/2
- Safety and Efficacy of Donafenib in Patients With Advanced Hepatocellular CarcinomaCompletedNCT02229071Phase 1/2
- A Study of DCC-2701 in Participants With Advanced Solid TumorsTerminatedNCT02228811Phase 1
- Oral Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors, AZD3759 or AZD9291, in Patients Who Have Advanced Non-Small Cell Lung CancerCompletedNCT02228369Phase 1
- Ceritinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Locally Advanced or Metastatic Pancreatic CancerCompletedNCT02227940Phase 1
- An Open-Label, Phase I/II Study of Nilotinib (Tasigna) and MEK-162 (ARRY-162) Used in Combination for Patients With Refractory or Advanced Chronic Myeloid Leukemia and Philadelphia Positive Acute Leukemia (Protocol CAMN107AUS41T)TerminatedNCT02225574Phase 1
- Cisplatin, Docetaxel, and Nintedanib Before Surgery in Treating Patients With Previously Untreated Stage IB-IIIA Non-small Cell Lung CancerCompletedNCT02225405Phase 1
- Study to Evaluate Safety and Tolerability of Single Ascending Doses of Multiple Formulations of PF-06650833 in Healthy Subjects Under Fasted and Fed ConditionsCompletedNCT02224651Phase 1
- Phase I Study to Assess Safety of AZD6738 Alone and in Combination With Radiotherapy in Patients With Solid TumoursStatus unknownNCT02223923Phase 1
- Effect Of Modafinil And Pioglitazone On The Pharmacokinetics Of Palbociclib (PD-0332991)CompletedNCT02222441Phase 1
- Alisertib and Fulvestrant in Treating Patients With Hormone Receptor Positive Breast Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by SurgeryCompletedNCT02219789Phase 1
- Ibrutinib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Diffuse Large B-cell LymphomaCompletedNCT02219737Phase 1
- Phase 1/1b Study of MGCD516 in Patients With Advanced CancerCompletedNCT02219711Phase 1
- Phase II Trial of HM781-36B in Patients With Metastatic/Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) After Failure of or Unfit for Platinum-containing TherapyStatus unknownNCT02216916Phase 2
- A Randomized Study of AZD2014 in Combination With Fulvestrant in Metastatic or Advanced Breast CancerCompletedNCT02216786Phase 2
- Evaluation of the Tolerance of Afatinib in Combination With Docetaxel and Cisplatin in LAHNSCC Induction ChemotherapyCompletedNCT02216617Phase 1
- Ph II CABOGIST in GISTCompletedNCT02216578Phase 2
- Temsirolimus and Cetuximab in Patients With Advanced or Metastatic Solid TumorsCompletedNCT02215720Phase 1
- Dose Escalation Study in Acute Myeloid or B-Cell Acute Lymphoblastic LeukemiaWithdrawnNCT02215629Phase 1
- Icotinib With Concurrent Radiotherapy Versus Chemotherapy With Concurrent Radiotherapy in Non-small Cell Lung CancerStatus unknownNCT02215356Phase 2
- Dose-finding Study of BI 2536 Administered in Combination With Gemcitabine in Patients With Locally Advanced or Metastatic Pancreatic CancerTerminatedNCT02215044Phase 1
- Efficacy, Safety and Pharmacokinetics of BIRB 796 BS Tablets in Patients With Active Rheumatoid ArthritisTerminatedNCT02214888Phase 2
- Treatment of Port Wine Stains Using Pulsed Dye Laser, Erbium Yag Laser and Topical SirolimusTerminatedNCT02214706Not applicable
- BI 2536 BS in Patients With Advanced Solid Tumours and Repeated Administration in Patients With Clinical BenefitCompletedNCT02211872Phase 1
- Dose Escalation Study of BI 2536 BS in Patients With Advanced Solid Tumours With Repeated Administration in Patients With Clinical BenefitCompletedNCT02211859Phase 1
- Dose Escalation Study of BI 2536 With Pemetrexed in Previously Treated Patients With Non-small-cell Lung CancerCompletedNCT02211833Phase 1
- Safety and Pharmacokinetics of BIRB 796 BS Tablets Administered to Healthy Human SubjectsCompletedNCT02209805Phase 1
- BIRB 796 BS Versus Placebo in Patients With Moderate to Severs Plaque-type PsoriasisCompletedNCT02209753Phase 2
- Effects of the Quadruple Immunosuppression on Peripheral Blood Lymphocytes and Development of Anti-HLA Antibodies in Kidney TransplantStatus unknownNCT02208791Phase 4
- mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and OvarianActive, not recruitingNCT02208375Phase 1
- Study to Assess the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profiles of UCB5857 in Healthy SubjectsCompletedNCT02207595Phase 1
- Crizotinib in Combination With Enzalutamide in Metastatic Castration-resistant Prostate CancerCompletedNCT02207504Phase 1
- A Phase 0 Study of AZD1775 in Recurrent GBM PatientsCompletedNCT02207010Early Phase 1
- Erlotinib and Momelotinib for the Treatment of Epidermal Growth Factor Receptor (EGFR) Mutated EGFR Tyrosine Kinase Inhibitor (TKI) Naive Metastatic Non-Small Cell Lung Cancer (NSCLC)TerminatedNCT02206763Phase 1
- An Open Label, Single-Centre, Pilot Study of Everolimus With EBRT for the Treatment of mNET Liver MetastasisCompletedNCT02205515Phase 1/2
- KD019 and Trastuzumab in Patients With Esophagus, Gastroesophageal Junction and Stomach CancerWithdrawnNCT02205463Phase 1