KRAS G12D Inhibitor VS-7375 clinical trials
Also written GFH375.
How each study uses KRAS G12D Inhibitor VS-7375 is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the KRAS G12D Inhibitor VS-7375 studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
11 studies that test it; most in 2026 (6)
| Year | Studies |
|---|---|
| 2024 | 1 |
| 2025 | 4 |
| 2026 | 6 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 11 · Other 0
Genfleet Therapeutics (Shanghai) Inc. (7) · Verastem, Inc. (4)
Often tested with
Tested in the same studies.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 6, 1 in phase 3
Studies that test KRAS G12D Inhibitor VS-7375, phase 3 first.
- Jun 2027Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic CancerPhase 3 · Genfleet Therapeutics (Shanghai) Inc.
- Apr 2027GFH375 Monotherapy and Combination Therapy as First-Line Treatment for Advanced KRAS G12D-Mutant Non-Small Cell Lung CancerPhase 2 · Genfleet Therapeutics (Shanghai) Inc.
- Jun 2027A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal CancerPhase 2 · Verastem, Inc.
- Jun 2027A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung CancerPhase 2 · Verastem, Inc.
- Jun 2027A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic CancerPhase 2 · Verastem, Inc.
- Jul 2027A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D MutationPhase 1/2 · Genfleet Therapeutics (Shanghai) Inc.
Studies
Open first, then newest update. How each study uses KRAS G12D Inhibitor VS-7375 is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 11
- A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal CancerRecruitingPhase 2Verastem, Inc.NCT07659795Written as VS-7375
- A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid TumorsRecruitingPhase 1/2Verastem, Inc.NCT07020221Written as VS-7375
- A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Non-Small Cell Lung CancerRecruitingPhase 2Verastem, Inc.NCT07659782Written as VS-7375
- A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic CancerRecruitingPhase 2Verastem, Inc.NCT07644559Written as VS-7375
- A Phase II Study of GFH375 Combined With GFS202A or GFH276 Versus GFH375 in Patients With Previously Treated Locally Advanced Unresectable or Metastatic Pancreatic Cancer Harboring KRAS G12D MutationRecruitingPhase 2Genfleet Therapeutics (Shanghai) Inc.NCT07784374Written as GFH375
- Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic CancerRecruitingPhase 3Genfleet Therapeutics (Shanghai) Inc.NCT07262567Written as GFH375
- A Study to Evaluate GFH375 Versus Docetaxel in Participants With Non-Small Cell Lung Cancer With KRAS G12D MutationRecruitingPhase 3Genfleet Therapeutics (Shanghai) Inc.NCT07668752Written as GFH375
- GFH375 Monotherapy and Combination Therapy as First-Line Treatment for Advanced KRAS G12D-Mutant Non-Small Cell Lung CancerNot yet recruitingPhase 2Genfleet Therapeutics (Shanghai) Inc.NCT07554859Written as ArmA:GFH375
- A Study of GFH375 Combined With Cetuximab or Chemotherapy in Participants With Solid Tumors Harboring KRAS G12D MutationRecruitingPhase 1/2Genfleet Therapeutics (Shanghai) Inc.NCT07259590Written as GFH375
- A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D MutationsRecruitingPhase 1/2Genfleet Therapeutics (Shanghai) Inc.NCT06500676Written as GFH375
- A Phase II Study to Evaluate GFH375 in Patients With KRAS G12D Mutant Metastatic Pancreatic CancerWithdrawnPhase 2Genfleet Therapeutics (Shanghai) Inc.NCT07026916Written as GFH375