Drug
KRAS G12D Inhibitor HRS-4642 clinical trials
Also written HRS-4642.
- studies test it
- 11
- open now
- 9
- in phase 3
- 0
- first study started
- 2022
Keep track of what changes. Save the KRAS G12D Inhibitor HRS-4642 studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
Studies by the year they started
11 studies that test it; most in 2026 (4)
| Year | Studies |
|---|---|
| 2022 | 1 |
| 2024 | 3 |
| 2025 | 3 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 5
- Phase 2
- 10
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 8
Jiangsu HengRui Medicine Co., Ltd. (2) · Fudan University (2) · Shanghai Zhongshan Hospital (2) · West China Hospital (1) · Changhai Hospital (1) · Henan Cancer Hospital (1) · The First Affiliated Hospital with Nanjing Medical University (1) · Shanghai Hengrui Pharmaceutical Co., Ltd. (1)
Often tested with
Tested in the same studies.
Adebrelimab (3) · Notiretatug rezetecan (2) · Nimotuzumab (1) · Fluorouracil/Liposomal Irinotecan/Leucovorin/Oxaliplatin Regimen (1) · SHR-1701 (1) · Anti-CTLA-4 Monoclonal Antibody SHR-8068 (1) · Xelox (1) · HRS-7058 (1)
Studies
Open first, then newest update. How each study uses KRAS G12D Inhibitor HRS-4642 is read from its arms, and is right about nine times in ten.
Testing it · 11
- An Exploratory Clinical Study of HRS-4642 in Combination With Immunotherapy and Chemotherapy for Pancreatic CancerRecruitingPhase 2Shanghai Zhongshan HospitalNCT06938282Written as HRS-4642
- A Phase II Study of HRS-4642 Combined With AG (Nab-paclitaxel and Gemcitabine) as Conversion Therapy for Locally Advanced Pancreatic CancerRecruitingPhase 2The First Affiliated Hospital with Nanjing Medical UniversityNCT07438106Written as HRS-4642 Injection
- Neoadjuvant HRS-4642 Plus Chemotherapy With or Without Immunotherapy for Pancreatic CancerNot yet recruitingPhase 2Changhai HospitalNCT07691593Written as HRS-4642+NALIRIFOX
- Umbrella Trial of Neoadjuvant Therapy for Locally Advanced Colorectal CancerNot yet recruitingPhase 2Fudan UniversityNCT07503639Written as HRS-4642
- HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid TumorsRecruitingPhase 1/2Shanghai Hengrui Pharmaceutical Co., Ltd.NCT07296341Written as HRS-4642;Adebrelimab Injection; nab-paclitaxel; gemcitabine
- Exploratory Platform Research on Precision Therapy of Advanced Pancreatic CancerRecruitingPhase 2Fudan UniversityNCT06547736Written as SHR-A2102, HRS4642 and Adebrelimab
- A Study of HRS-4642 in Combination With Antineoplastic Agents in Advanced Solid TumorsRecruitingPhase 1/2Jiangsu HengRui Medicine Co., Ltd.NCT06520488Written as HRS-4642
- Clinical Trial of HRS-4642 Plus SHR-A2102 in Patients With Advanced Solid TumorsNot yet recruitingPhase 1/2Henan Cancer HospitalNCT06955390Written as SHR-A2102+HRS-4642
- A Study of HRS-4642 Monotherapy or in Combination With Adebrelimab in the Treatment of Advanced Biliary Tract Tumors.RecruitingPhase 2Shanghai Zhongshan HospitalNCT06620848Written as HRS-4642 monotherapy
- HRS-4642 Combined With Nimotuzumab in the Treatment of Recurrent or Metastatic Pancreatic Ductal AdenocarcinomaActive, not recruitingPhase 1/2West China HospitalNCT06773130Written as HRS-4642
- Phase I Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D MutationActive, not recruitingPhase 1Jiangsu HengRui Medicine Co., Ltd.NCT05533463Written as HRS-4642
Given in every arm · 3 — KRAS G12D Inhibitor HRS-4642 is usual care beside what is tested
- HRS-4642 With Nimotuzumab and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer PatientsRecruitingPhase 2Zhejiang UniversityNCT06770452Written as HRS-4642
- Exploratory Clinical Study of HRS-4642 Combined With Adebrelimab in the Treatment of Advanced Pancreatic Ductal AdenocarcinomaRecruitingPhase 1/2Fudan UniversityNCT06427239Written as HRS-4642
- A Study of HRS-4642 in Patients With Advanced Solid Tumors Harboring KRAS G12D MutationActive, not recruitingPhase 1/2Jiangsu HengRui Medicine Co., Ltd.NCT06385678Written as HRS-4642