Dipeptidyl-Peptidase IV Inhibitors: all 899 studies that test it

Page 1 of 9. Open to participants first (28), then studies with results posted, then the rest; newest registration first within each.

• Efficacy of Vildagliptin Versus Metformin in Patients With Polycystic Ovary SyndromeNot yet recruitingNCT07811011Phase 2/3
• Disease-modifying Efficacy of Sitagliptin Therapy in Early-stage Parkinson's DiseaseNot yet recruitingNCT07804381Phase 2
• Sun Yat-Sen Treatment Strategy for Enhancing Response in Muscle-invasive Bladder CancerRecruitingNCT07717242Phase 2
• Sitagliptin With Pembro in RCC and MelanomaRecruitingNCT07634380Phase 1
• Sitagliptin in Recurrent/Progressive Grade 4 GliomaRecruitingNCT07541781Phase 1
• Effects of Cofrogliptin on Beta-Cell Function in LADA PatientsNot yet recruitingNCT07460336Not applicable
• Metformin, Empagliflozin With Sitagliptin vs Linagliptin in Type 2 DiabetesEnrolling by invitationNCT07452913Phase 4
• Glycemic Variability of Combination Therapies in T2DMRecruitingNCT07442006Phase 4
• Comparative Study Between (SGLT-2i) and (DPP-4i) in the Prevention of DICRecruitingNCT07436663Phase 4
• Neoadjuvant Chemotherapy, Anti-PD-1 Antibody and Sitagliptin for Locally Advanced pMMR CRCRecruitingNCT07365592Phase 1/2
• A Multicenter, Randomized, Open-Label, Parallel-Controlled Clinical Study Comparing the Efficacy and Safety of Cofrogliptin Versus Acarbose in Drug-Naïve Patients With Type 2 DiabetesNot yet recruitingNCT07122102Not applicable
• Effect of Add-on SGLT2i, TZD, or Combination Therapy in Type 2 Diabetes Patients on DPP4 InhibitorsNot yet recruitingNCT07108985Phase 4
• Comparison Between Efficacy of Trelagliptin and Sitagliptin in Type II Diabetic PatientsEnrolling by invitationNCT07073768Phase 3
• A Phase 2 and Pharmacodynamic Study of Sitagliptin in Patients With Progressive Grade 4 GliomasRecruitingNCT07003542Phase 2
• Clinical Trial of Vildagliptin in Early Parkinson's DiseaseNot yet recruitingNCT06951334Not applicable
• Glycemic Control With Triple Pathway Approach Through Empagliflozin, Linagliptin and Metformin CombinationRecruitingNCT06862739Phase 4
• Sitagliptin or BeiDouGen Capsule Improve the Pregnancy Outcome in Patients with PCOSRecruitingNCT06587698Not applicable
• Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in BangladeshNot yet recruitingNCT06449235Phase 4
• The Bioequivalence Study of Fixed-dose Combination of Vildagliptin and Metformin HCI 50/1000 mg FCT Under Fed ConditionsNot yet recruitingNCT06244407Phase 1
• The Bioequivalence Study of Linagliptin 5 mg Film-coated Tablet in Healthy Thai VolunteersNot yet recruitingNCT06243809Phase 1
• The Effects of DPPIs on Cognitive Function of Diabetic PatientsNot yet recruitingNCT06164535Phase 4
• Efficacy of Vildagliptin Versus Metformin in Poly Cystic Ovary SyndromeRecruitingNCT06142656Phase 2/3
• A Trial of SP2086 With Hepatic InsufficiencyNot yet recruitingNCT06035406Phase 1
• Dutogliptin in Co-administration With Filgrastim in Early Recovery Post-myocardial InfarctionNot yet recruitingNCT05881382Phase 3
• Effects of Sitagliptin in Relatives of T1D PatientsNot yet recruitingNCT05219409Phase 2/3
• Sitagliptin for the Treatment of Type 2 DiabetesRecruitingNCT04495881Phase 4
• Clinical Study Evaluating Vildagliptin Versus Vildagliptin/Metformin on NAFLD With DMRecruitingNCT03925701Phase 3
• Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)RecruitingNCT02969798Not applicable
• Anti-Diabetic Medications to Fight PD and LBDCompletedNCT06263673Phase 4Results posted
• To Assess Safety of Fixed Dose Combination of Dapagliflozin and Saxagliptin in Type 2 Diabetes Mellitus PatientsCompletedNCT04445714Phase 4Results posted
• A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 DiabetesCompletedNCT04017832Phase 3Results posted
• Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1TerminatedNCT03738878Phase 4Results posted
• This Study in Healthy People Tests Whether Taking a Low Strength of Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate PillsCompletedNCT03629054Phase 1Results posted
• A Study to Determine the Bioequivalence of Alogliptin and Pioglitazone When Administered as Individual Tablets and as Fixed-Dose Combination (FDC)-SYR-322-4833 BL Tablets to Healthy Russian ParticipantsCompletedNCT03501277Phase 1Results posted
• Diabetes Study of Linagliptin and Empagliflozin in Children and Adolescents (DINAMO)TMCompletedNCT03429543Phase 3Results posted
• Sitagliptin and the Risk for Hypoglycaemia in Type 2 Diabetes PatientsCompletedNCT03359590Phase 2Results posted
• A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer)TerminatedNCT03337698Phase 1/2Results posted
• A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)TerminatedNCT03281369Phase 1/2Results posted
• An Efficacy Study of Canagliflozin or Sitagliptin to Determine Glucose Variability in Mexican Participants With Type 2 Diabetes Mellitus Inadequately Controlled on MetforminCompletedNCT03267576Phase 4Results posted
• This Study Tests Whether Taking the Medicines Empagliflozin, Linagliptin, and Metformin Together in 1 Pill is the Same as Taking Them in Separate Pills. The Study is Done in Healthy Men and Women and Measures the Amount of Each Medicine in the BloodCompletedNCT03259490Phase 1Results posted
• Treatment Preference for Weekly Dipeptidyl Peptidase-4 (DPP-4) Inhibitors Versus Daily DPP-4 Inhibitors in Participants With Type 2 Diabetes MellitusCompletedNCT03231709Phase 4Results posted
• Study to Evaluate Safety and Efficacy of Dapagliflozin and Saxagliptin in Patients With Type 2 Diabetes Mellitus (T2DM) Aged 10 to Below 18 Years OldCompletedNCT03199053Phase 3Results posted
• Safety and Efficacy of Bexagliflozin Compared to Sitagliptin as Add-on Therapy to Metformin in Type 2 Diabetes SubjectsCompletedNCT03115112Phase 3Results posted
• SNP Study of DPP-4 and GLP-1R in Chinese People (Including Diabetes Patients)CompletedNCT03108521Phase 4Results posted
• Study of the QOL Evaluation of Trelagliptin in Patients With Type 2 Diabetes MellitusCompletedNCT03014479Phase 4Results posted
• Interaction of Bexagliflozin With Metformin, Glimepiride and SitagliptinCompletedNCT02956044Phase 1Results posted
• Efficacy and Safety of Teneligliptin in Combination With Metformin in Chinese Patients With Type 2 Diabetes MellitusCompletedNCT02924064Phase 3Results posted
• Treatment of Diabetes in Patients With Systolic Heart FailureCompletedNCT02920918Phase 4Results posted
• Mechanistic Evaluation of Glucose-lowering Strategies in Patients With Heart FailureCompletedNCT02917031Phase 4Results posted
• Efficacy and Safety of Teneligliptin in Chinese Patients With Type 2 Diabetes MellitusCompletedNCT02916706Phase 3Results posted
• Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)CompletedNCT02906709Phase 4Results posted
• Linagliptin Add-on to Insulin Background TherapyCompletedNCT02897349Phase 3Results posted
• Phase 3 Alogliptin Pediatric StudyCompletedNCT02856113Phase 3Results posted
• Empa/Lina FDC Food Effect Study (Japan)CompletedNCT02815644Phase 1Results posted
• A Study of the Safety and Efficacy of Sitagliptin Addition During Metformin Up-titration (MK-0431-848)CompletedNCT02791490Phase 3Results posted
• An Exploratory Study of the Effects of Trelagliptin and Alogliptin on Glucose Variability in Patients With Type 2 Diabetes MellitusCompletedNCT02771093Phase 4Results posted
• Bioequivalence of a Fixed Dose Combination Tablet of Empagliflozin/Linagliptin Compared With the Free Combination of Empagliflozin Tablet and Linagliptin Tablet in Healthy Male and Female SubjectsCompletedNCT02758171Phase 1Results posted
• Sitagliptin in Non-Diabetic Patients Undergoing General SurgeryCompletedNCT02741687Phase 4Results posted
• Randomized Sitagliptin Withdrawal Study (MK-0431-845)CompletedNCT02738879Phase 3Results posted
• Sitagliptin for Prevention of Acute Graft Versus-Host Disease After Allogeneic Hematopoietic Stem Cell TransplantationCompletedNCT02683525Phase 2Results posted
• DPP4 Inhibition & Beta Cell FunctionCompletedNCT02683187Phase 1Results posted
• A Multi-Center, Randomized, Double-Blind, Phase III Trial to Evaluate the Safety and Efficacy of Saxagliptin Co-administered With Dapagliflozin Compared to Saxagliptin or Dapagliflozin All Given as add-on Therapy to Metformin in Subject With Type 2 DiabetesCompletedNCT02681094Phase 3Results posted
• Remission Evaluation of a Metabolic Intervention in Type 2 Diabetes With Sitagliptin (REMIT-Sita)CompletedNCT02623998Phase 3Results posted
• ESR-15-11293 - Saxa/Dapa, Safety and Efficacy StudyCompletedNCT02613897Not applicableResults posted
• Continuous Glucose Monitoring to Assess Glycemia in Chronic Kidney Disease - Changing Glucose ManagementCompletedNCT02608177Not applicableResults posted
• Double-blind Sitagliptin Add-on Study in Japanese Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Ipragliflozin (MK-0431J-842)CompletedNCT02577016Phase 3Results posted
• Ipragliflozin Add-on Long-term Study in Japanese Participants With Type 2 Diabetes Mellitus on Sitagliptin (MK-0431J-849)CompletedNCT02564211Phase 3Results posted
• Sitagliptin for Hyperglycemia in Patients With T2DM Undergoing Cardiac SurgeryCompletedNCT02556918Phase 4Results posted
• A Study to Evaluate the Effect of Dapagliflozin With and Without Saxagliptin on Albuminuria, and to Investigate the Effect of Dapagliflozin and Saxagliptin on HbA1c in Patients With Type 2 Diabetes and CKDCompletedNCT02547935Phase 2/3Results posted
• Sitagliptin Therapy and Kinetics of Inflammatory MarkersCompletedNCT02536248Phase 3Results posted
• A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838)CompletedNCT02532855Phase 3Results posted
• Sitagliptin for Reducing Inflammation and Immune ActivationCompletedNCT02513771Phase 2Results posted
• A Phase 3, Randomized, Double-blind, Parallel-group, Comparative Study and a Phase 3, Multicenter, Open-label, Long-term Study of SYR-472 (25 mg) in Patients With Type 2 Diabetes Mellitus Complicated by Severe Renal Impairment or End-stage Renal DiseaseCompletedNCT02512068Phase 3Results posted
• Vildagliptin Versus Dapagliflozin on GlucagonCompletedNCT02475070Phase 4Results posted
• Efficacy and Safety of Dapagliflozin and Dapagliflozin Plus Saxagliptin in Combination With Metformin in Type 2 Diabetes Patients Compared With SulphonylureaCompletedNCT02471404Phase 4Results posted
• Linagliptin's Effect on CD34+ Stem CellsCompletedNCT02467478Phase 4Results posted
• Sitagliptin in Non-Diabetic Patients Undergoing Cardiac SurgeryCompletedNCT02443402Phase 4Results posted
• A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin AloneCompletedNCT02419612Phase 3Results posted
• The INDORSE Study: Inhibition of Dipeptidyl Peptidase IV: Outcomes on Renal Sodium ExcretionCompletedNCT02406443Phase 4Results posted
• Risk of Nocturnal Hypoglycemia and Arrhythmias With Sitagliptin Versus Glimepiride in Patients With Type 2 DiabetesTerminatedNCT02373865Phase 4Results posted
• The Effect of LINAGLIPTIN on Inflammation, Oxidative Stress and Insulin Resistance in Obese Type 2 Diabetes SubjectsCompletedNCT02372630Phase 4Results posted
• A Phase 1, Bioequivalence Study of SYR-472 25mg and 50mg TabletsCompletedNCT02372097Phase 1Results posted
• Fatty Liver Study in Patients With Type II DiabetesTerminatedNCT02365233Phase 4Results posted
• Confirmatory Study of MT-2412 in Japanese Patients With Type 2 Diabetes (Add-on Study of Teneligliptin)CompletedNCT02354222Phase 3Results posted
• Effects of Linagliptin on Endothelial FunctionCompletedNCT02350478Phase 4Results posted
• Randomized Trial Comparing Sitagliptin to Placebo in Closed LoopCompletedNCT02328040Phase 1Results posted
• A Phase 4, Randomized, Double-blind, Parallel-group, Comparative Study and a Phase 4, Open-label, Long-term Study of SYR-472 (100 mg) in Combination With Insulin in Patients With Type 2 DiabetesCompletedNCT02324569Phase 3Results posted
• Efficacy of Sitagliptin and Glibenclamide on the Glucose Variability in Japanese Participants With Type 2 Diabetes Mellitus (MK-0431-355)CompletedNCT02318693Phase 4Results posted
• Long-term Safety Study of MP-513 as Monotherapy or in Combination With Sulfonylurea in Japanese Type 2 Diabetic PatientsCompletedNCT02314637Phase 3Results posted
• Dietary Impacts on Glucose-lowering Effects of Sitagliptin in Type 2 DiabetesCompletedNCT02312063Phase 4Results posted
• Study to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin in Combination With Metformin Compared to Sitagliptin in Combination With Metformin in Adult Patients With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Therapy AloneCompletedNCT02284893Phase 3Results posted
• Effect of Food on the Pharmacokinetics of Single Oral Dose Administration of a Fixed-Dose Combination of SYR-322 and Metformin Hydrochloride in Healthy Adult Male SubjectsCompletedNCT02276274Phase 3Results posted
• Evaluate the Efficacy and Safety of Saxagliptin in Combination With Metformin IR Compared to Saxagliptin Monotherapy and to Metformin IR Monotherapy in Drug Naive Chinese Subjects With Type 2 Diabetes Who Have Inadequate Glycaemic ControlCompletedNCT02273050Phase 3Results posted
• Sitagliptin and Glucagon CounterregulationCompletedNCT02256189Phase 4Results posted
• 24-Week, Multicenter, Randomized, Parallel-group, Open-label, Active Controlled Phase IV Study to Assess the Efficacy, Safety and Tolerability of Saxagliptin Compared With Acarbose When in Combination With Metformin in Patients With T2D Inadequately Controlled With Metformin MonotherapyCompletedNCT02243176Phase 4Results posted
• Linagliptin as Add on to Basal Insulin in the ElderlyCompletedNCT02240680Phase 4Results posted
• Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017)CompletedNCT02226003Phase 3Results posted
• Bioequivalence Study Coadministered to Healthy Subjects in the Fasted StateCompletedNCT02223065Phase 1Results posted
• Long-Term Safety Study of MT-2412 in Japanese Patients With Type 2 DiabetesCompletedNCT02220907Phase 3Results posted
• Safety and Efficacy of Saxagliptin for Glycemic Control in Non-Critically Ill Hospitalized PatientCompletedNCT02182895Phase 4Results posted

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