Drug
Calderasib clinical trials
Also written MK-1084.
- studies test it
- 10
- open now
- 5
- in phase 3
- 5
- first study started
- 2024
Keep track of what changes. Save the calderasib studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Development codes
- MK-1084
- 10
Studies by the year they started
10 studies that test it; most in 2025 (5)
| Year | Studies |
|---|---|
| 2024 | 3 |
| 2025 | 5 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 5
- Phase 3
- 5
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 10 · Other 0
Often tested with
Tested in the same studies.
Studies
Open first, then newest update. How each study uses calderasib is read from its arms, and is right about nine times in ten.
Testing it · 10
- A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06345729Written as Calderasib
- A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07554339Written as Calderasib
- MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07431827Written as Calderasib
- A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06997497Written as Calderasib
- A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)RecruitingPhase 3Merck Sharp & Dohme LLCNCT07190248Written as Calderasib
- A Study of Calderasib (MK-1084) in Participants With Hepatic Impairment and Healthy Volunteers (MK-1084-017)CompletedPhase 1Merck Sharp & Dohme LLCNCT07219550Written as Calderasib
- A Clinical Study of Calderasib (MK-1084) With Rosuvastatin and Metformin in Healthy People (MK-1084-016)CompletedPhase 1Merck Sharp & Dohme LLCNCT07222098Written as Calderasib
- A Study of Calderasib (MK-1084) Human Absorption, Distribution, Metabolism, and Excretion in Healthy Adult Participants (MK-1084-006)CompletedPhase 1Merck Sharp & Dohme LLCNCT06687759Written as [14C]Calderasib
- A Clinical Study of Calderasib (MK-1084) in Participants With Renal Impairment (MK-1084-010)CompletedPhase 1Merck Sharp & Dohme LLCNCT06814119Written as Calderasib
- A Study of Calderasib (MK-1084) With Midazolam and Digoxin in Healthy Participants (MK-1084-009)CompletedPhase 1Merck Sharp & Dohme LLCNCT06575933Written as Calderasib
Given in every arm · 7 — calderasib is usual care beside what is tested
- A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)RecruitingPhase 1Merck Sharp & Dohme LLCNCT05067283Written as Calderasib
- A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)RecruitingPhase 2Merck Sharp & Dohme LLCNCT07209111Written as Calderasib
- A Clinical Study of MK-1084 With Other Treatments for Non-small Cell Lung Cancer (MK-3475-01F)RecruitingPhase 1/2Merck Sharp & Dohme LLCNCT07286149Written as MK-1084
- KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)RecruitingPhase 2Merck Sharp & Dohme LLCNCT07252739Written as MK-1084
- Study of MK-0472 in Participants With Advanced/Metastatic Solid Tumors (MK-0472-001)Active, not recruitingPhase 1Merck Sharp & Dohme LLCNCT05853367Written as MK-1084
- A Study to Evaluate the Effect of Food, Formulation, and a Proton Pump Inhibitor (PPI) on Calderasib (MK-1084) in Healthy Adult Participants (MK-1084-003)CompletedPhase 1Merck Sharp & Dohme LLCNCT06619314Written as Calderasib
- A Study of the Effect of Itraconazole and Phenytoin on Calderasib (MK-1084) in Healthy Adults (MK-1084-008)CompletedPhase 1Merck Sharp & Dohme LLCNCT06719557Written as Calderasib
Codes
What other systems call calderasib · ClinicalTrials.gg INT018612
- UNII (FDA) YQF4ART47CCALDERASIBConfirmed FDA, Wikidata
- Wikidata Q140528731calderasibConfirmed FDA, Wikidata
- NCI Thesaurus C185288CalderasibOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | YQF4ART47C | CALDERASIB | Confirmed FDA, Wikidata |
| Wikidata | Q140528731 | calderasib | Confirmed FDA, Wikidata |
| NCI Thesaurus | C185288 | Calderasib | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.