Aliskiren: all 132 studies that test it

Page 1 of 2. Open to participants first (1), then studies with results posted, then the rest; newest registration first within each.

• Evaluation of a Renin Inhibitor, Aliskiren, Compared to Enalapril, in C3 GlomerulopathyRecruitingNCT04183101Phase 2
• The Effects of Renin Inhibition on Fibrinolytic Balance and Endothelial FunctionCompletedNCT03115853Phase 4Results posted
• Comparison of Aliskiren vs Negative Controls on Aortic Stiffness in Patients With MFSCompletedNCT01715207Phase 3Results posted
• 8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With HypertensionCompletedNCT01570686Phase 4Results posted
• Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With HypertensionCompletedNCT01519635Phase 4Results posted
• Shiga Microalbuminuria Reduction Trial-2CompletedNCT01461499Phase 4Results posted
• Effect of Short Term Aliskiren Treatment in Kidney Transplant PatientsTerminatedNCT01437943Phase 4Results posted
• Aliskiren Effect on Aortic Plaque ProgressionTerminatedNCT01417104Phase 2/3Results posted
• Effect of the Direct Renin Inhibitor Aliskiren on Endothelial Function and Arterial Stiffness in Diabetic SubjectsTerminatedNCT01349114Phase 4Results posted
• To Study the Effects of Aliskiren on Albuminuria and Various Biomarkers in Patients With NephropathyTerminatedNCT01302899Phase 2Results posted
• Effects of Aliskiren in Elderly Hypertensive Chronic Kidney Disease (CKD) PatientsCompletedNCT01284114Phase 4Results posted
• A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly PeopleTerminatedNCT01259297Phase 3Results posted
• Assessment of Renin Inhibition on Insulin Sensitivity, Diastolic Function and Aortic ComplianceTerminatedNCT01252238Not applicableResults posted
• Clinical Pharmacology of Aliskiren in Combination With Cyclosporine in Cardiac TransplantationTerminatedNCT01235910Phase 4Results posted
• ALiskiren or Losartan Effects on bioMARKers of Myocardial RemodelingCompletedNCT01176032Phase 4Results posted
• The Effect of Aliskiren on Endothelial Function in Pre-Diabetes and DiabetesCompletedNCT01165983Not applicableResults posted
• An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of AgeCompletedNCT01151410Phase 3Results posted
• Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of AgeCompletedNCT01150357Phase 3Results posted
• Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney DiseaseTerminatedNCT01129557Phase 4Results posted
• A Study to Investigate the Pharmacodynamic and Pharmacokinetic Interaction Between Aliskiren and Furosemide in Patients With Heart FailureCompletedNCT01125514Phase 2Results posted
• Aldosterone and the Metabolic SyndromeCompletedNCT01103245Phase 1Results posted
• Assessment of Aliskiren/Amlodipine and Amlodipine on Ankle Foot Volume (AFV) in Patients With HypertensionTerminatedNCT01080768Phase 2Results posted
• The Effect of Tekturna on Endothelial Function and Endothelial Progenitor Cells in Patients With Early AtherosclerosisTerminatedNCT01067326Phase 3Results posted
• Efficacy of Aliskiren Compared to Ramipril in the Treatment of Moderate Systolic Hypertensive PatientsCompletedNCT01042392Phase 4Results posted
• Effects of Aliskiren on Patient With Heart Failure and a Normal Ejection FractionCompletedNCT00982033Phase 4Results posted
• Vitamin D Deficiency in Patients With HypertensionTerminatedNCT00974922Phase 4Results posted
• The Effect of Renin Inhibition on Nerve Function in DiabetesCompletedNCT00935064Not applicableResults posted
• Aliskiren and Valsartan vs Valsartan Alone in Patients With Stage II Systolic Hypertension and Type II Diabetes MellitusCompletedNCT00927394Phase 4Results posted
• Effects of Aliskiren, Ramipril, and the Combination on Levels of Angiotensin II in Patients With Decompensated Systolic Heart FailureCompletedNCT00923156Phase 2Results posted
• Six Months Efficacy and Safety of Aliskiren Therapy on Top of Standard Therapy, on Morbidity and Mortality in Patients With Acute Decompensated Heart FailureCompletedNCT00894387Phase 3Results posted
• Efficacy and Safety of Aliskiren 300 mg Compared to Telmisartan 80 mg After 1 Week of Treatment WithdrawalCompletedNCT00865020Phase 4Results posted
• Efficacy and Safety of Aliskiren Administered in Combination With Amlodipine Versus Amlodipine Alone in African American Patients With Stage 2 HypertensionCompletedNCT00853957Phase 4Results posted
• Safety and Efficacy of Aliskiren on the Progression of Atherosclerosis in Coronary Artery Disease PatientsCompletedNCT00853827Phase 3Results posted
• Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart FailureCompletedNCT00853658Phase 3Results posted
• Efficacy and Safety of Aliskiren in Patients With Mild to Moderate Hypertension During ExerciseCompletedNCT00819767Phase 2Results posted
• Direct Renin Inhibition Effects on Atherosclerotic BiomarkersCompletedNCT00818779Phase 4Results posted
• 8 Weeks Study to Evaluate the Efficacy and Safety of Valsartan in Combination With Aliskiren Compared to Valsartan Alone in Patients With Stage 2 HypertensionCompletedNCT00809926Phase 4Results posted
• Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for HypertensionCompletedNCT00797862Phase 3Results posted
• Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes MellitusCompletedNCT00787605Phase 4Results posted
• Efficacy of Aliskiren in the Treatment of Diabetic Macular EdemaTerminatedNCT00768040Phase 2Results posted
• Efficacy and Tolerability of an Aliskiren-based Treatment Algorithm in Patients With Mild to Moderate HypertensionCompletedNCT00765947Phase 4Results posted
• Efficacy and Safety of Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Moderate-severe HypertensionCompletedNCT00765674Phase 3Results posted
• Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older PopulationCompletedNCT00760266Phase 4Results posted
• Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Amlodipine in Essential HypertensionCompletedNCT00739973Phase 3Results posted
• Efficacy and Safety of Aliskiren 75 mg, 150 mg, and 300 mg in Elderly Patients With Essential Hypertension When Given With a Light Meal in a 8 Week Placebo-controlled StudyCompletedNCT00706134Phase 3Results posted
• A Long Term Safety Study to Test the Combination of Aliskiren/ Amlodipine / Hydrochlorothiazide in Participants With Essential HypertensionCompletedNCT00667719Phase 3Results posted
• A Clinical Study to Evaluate Renal Hemodynamic Responses to Aliskiren in Patients With Type 2 Diabetes MellitusCompletedNCT00660309Phase 4Results posted
• Efficacy and Safety of Once Daily Dosing of Aliskiren (300 mg (qd) Once a Day) to Twice Daily Dosing of Aliskiren (150 mg (Bid) Twice a Day) in Treating Moderate Hypertension.CompletedNCT00654875Phase 4Results posted
• A Study Evaluating the Gastrointestinal (GI) Safety and Tolerability of Aliskiren Compared to Ramipril in Essential HypertensionCompletedNCT00631917Phase 4Results posted
• Combined Renin Inhibition/Beta-blockadeTerminatedNCT00627861Not applicableResults posted
• Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (Core and Extension Phases)TerminatedNCT00549757Phase 3Results posted
• Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic SyndromeTerminatedNCT00542269Phase 4Results posted
• Safety and Efficacy of Aliskiren 300 mg, 150 mg and 75 mg in Patients With Essential Hypertension Compared to Ramipril 5 mgCompletedNCT00529451Phase 3Results posted
• Effects of Aliskiren and Amlodipine on the Renin-Angiotensin System (RAS) and Lipid/Carbohydrate Metabolism in Obese Patients With HypertensionTerminatedNCT00498433Phase 2Results posted
• Effect of High and Low Sodium Diets on Blood Pressure in Hypertensive Patients Treated With AliskirenCompletedNCT00441064Phase 4Results posted
• Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic SyndromeCompletedNCT00417170Phase 2Results posted
• Safety and Efficacy of Aliskiren in Post Myocardial Infarction Patients (ASPIRE)CompletedNCT00414609Phase 3Results posted
• Efficacy and Safety of Aliskiren and Valsartan Versus Placebo in Patients Stabilized Following an Acute Coronary SyndromeCompletedNCT00409578Phase 2Results posted
• A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the ElderlyCompletedNCT00368277Phase 3Results posted
• Role of ALiskiren, a Direct Renin Inhibitor, in Preventing Atrial Fibrillation in Patients With a Pacemaker; RALF.Status unknownNCT02909166Phase 3
• Influence of Aliskiren on Albuminuria After Kidney TransplantationCompletedNCT02446548Not applicable
• Aliskiren Study of Safety and Efficacy in Senior HypertensivesWithdrawnNCT01922141Phase 4
• Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular HypertrophyStatus unknownNCT01893788Phase 4
• RAS Quantification in Patients With Aliskiren or CandesartanCompletedNCT01827202Phase 4
• RAAS Inhibitor Drugs in Dialysis PatientsStatus unknownNCT01635387Phase 4
• Pharmacokinetics, Safety and Tolerability of Aliskiren (SPP100) in Patients With End Stage Renal Disease on Hemodialysis and Matched Healthy SubjectsCompletedNCT01568775Phase 1
• The Effect of Various Types of the Renin-angiotensin-aldosterone System Blockade on ProteinuriaCompletedNCT01541267Phase 4
• Study on Anti-inflammatory Effect of Anti-hypertensive Treatment in Patients With Small AAA's and Mild HypertensionTerminatedNCT01425242Not applicable
• Comparison of Amlodipine and Aliskiren in Diabetic Hypertensive Patient With Blood Pressure Not Controlled by LosartanWithdrawnNCT01409408Phase 4
• Aliskiren or Amlodipine in Hypertensive Hemodialysed PatientsStatus unknownNCT01394770Phase 4
• Aliskiren on Retinal Vasculature Treatment StudyCompletedNCT01318395Phase 3
• The Effect of Aliskiren and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis PatientsStatus unknownNCT01305850Phase 4
• Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart FailureStatus unknownNCT01298258Not applicable
• Influence of Aliskiren on ProteinuriaCompletedNCT01219413Phase 4
• A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA NephropathyStatus unknownNCT01184599Phase 4
• Significance of Regional Ventriculo-arterial Coupling in Patients With Chronic Heart FailureStatus unknownNCT01156207Phase 4
• Aliskiren Combined With Losartan in Proteinuric, Non-diabetic Chronic Kidney DiseaseCompletedNCT01150201Phase 4
• Treatment of Adiposity Related hypErTension (TARGET)CompletedNCT01138423Phase 4
• Aliskiren in Combination With Amlodipine in Hypertensive Patients Not Responding to Angiotensin Receptor Blocker (ARB) Plus AmlodipineCompletedNCT01113047Phase 3
• Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive DiabeticsStatus unknownNCT01095822Phase 4
• Aliskiren in Patients With Idiopathic Membranous NephropathyWithdrawnNCT01093781Not applicable
• Efficacy and Safety of Combination Therapy of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Stage II HypertensionCompletedNCT01070030Phase 4
• Evaluation of Aliskiren Efficacy by Different Methods of Blood Pressure MeasurementsTerminatedNCT01060865Phase 4
• A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients.CompletedNCT01056731Phase 4
• Effects of Aliskiren/Amlodipine Versus Amlodipine Monotherapy on Ankle-foot Volume in Hypertensive PatientsStatus unknownNCT01048047Phase 4
• Add-on Aliskiren Treatment in Patients With Chronic Congestive Heart FailureStatus unknownNCT01040494Phase 4
• Evaluating the Effect of Aliskiren Versus HCTZ on Coronary Flow Reserve in Hypertensive Type II DiabeticsWithdrawnNCT00994253Phase 4
• Triple Blockade of the Renin Angiotensin Aldosterone System in Diabetic (Type 1&2) Proteinuric PatientsTerminatedNCT00961207Phase 4
• Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive PatientsCompletedNCT00939588Phase 2
• Effect of Light Meal on Pharmacokinetic and Pharmacodynamics of Aliskiren in Patients With Mild to Moderate HypertensionCompletedNCT00933920Phase 1
• Aliskiren for Proteinuric IgAN Despite Angiotensin BlockadeCompletedNCT00922311Phase 4
• Safety and Efficacy Study of Add On Aliskiren in Patients With Heart Failure and Renal ImpairmentTerminatedNCT00881439Phase 2
• Aliskiren for Immunoglobulin A (IgA) NephropathyCompletedNCT00870493Phase 3
• The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)CompletedNCT00856960Phase 1
• Aliskiren and Renin Inhibition in Diastolic Heart FailureWithdrawnNCT00773084Not applicable
• Aliskiren's Effect on Arterial Stiffness and Platelet Function in Patients With Diabetes Mellitus (DM)Status unknownNCT00732407Not applicable
• Aliskiren and Muscle Sympathetic Nerve ActivityStatus unknownNCT00719316Phase 4
• Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium DietCompletedNCT00518765Phase 3
• Effects of Aliskiren, Irbesartan, and the Combination in Hypertensive Patients With Type 2 Diabetes and Diabetic NephropathyCompletedNCT00464880Phase 1/2
• Study to Assess the Optimal Renoprotective Dose of Aliskiren in Hypertensive Patients With Type 2 Diabetes and Incipient or Overt NephropathyCompletedNCT00464776Phase 1/2

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