Klippel-Trenaunay-Weber Syndrome clinical trials
The registry lists 8 studies for Klippel-Trenaunay-Weber Syndrome across more than 10 countries. 4 are recruiting or about to start. 2 of them are mainly about Klippel-Trenaunay-Weber Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
Children's Hospital Medical Center, Cincinnati (1) · Kaken Pharmaceutical (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Sonablate (1) · Boston Children's Hospital (1) · University Hospital, Tours (1) · Relay Therapeutics, Inc. (1) · Mayo Clinic (1)
Who develops what
Save this setEvery programme with a company-led study here in the last two years, whatever its size: 2 programmes from 2 companies, 0 with this as their studies’ main aim; 1 with a live phase 3 study; 0 primary completions in the next 12 months.
Comparator & background therapies
What other companies’ phase 2+ studies give as the comparator or the background here (its leading trial sponsor and partners left out): a sign of what new drugs are measured against, not by itself the standard of care, its prescriptions or its market.
None given by two companies or more yet.
Programmes
“Meets, by arms” reads each study’s arms: vs its arm against the therapy’s; + X vs a combination against it; added to it plus the therapy against the therapy; studied with given together only. The next primary completion is the next phase-3 study’s when there is one.
The 2 programmes — sign in to see the whole list, free: filter by phase and aim, sort by late development, direct comparisons or the next primary completion.
Primary completion in the next 12 months (0)
Live phase 2 and 3 studies of these programmes. Primary completion is when the main measure’s data collection ends, as the registry states it (most are estimates); results come later, if they are announced.
None in the next 12 months.
Read from ClinicalTrials.gov, industry-led studies. Main aim: this is the study’s judged main condition; named, not the main aim: the sponsor names it, the study is about something else; registry mapping only: only the registry’s mapping put it here. Leading trial sponsor is the company leading the most industry studies of a drug, a measure of trial activity, not of rights. Phase 4 trial recorded: a phase 4 study exists somewhere; approval here is not checked. Not read yet: approvals and labels, exclusivity, licences, line of therapy, academic comparators, sales.
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
Who these studies take
Of the 4 Klippel-Trenaunay-Weber Syndrome studies recruiting now, 4 (100%) set no upper age limit and 0 (0%) stop at 75 or younger. 4 (100%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (100%) | 4 (100%) |
| 18 | 4 (100%) | 4 (100%) |
| 30 | 4 (100%) | 4 (100%) |
| 40 | 4 (100%) | 4 (100%) |
| 50 | 4 (100%) | 4 (100%) |
| 65 | 4 (100%) | 4 (100%) |
| 75 | 4 (100%) | 4 (100%) |
| 85 | 4 (100%) | 4 (100%) |
Across all 8 studies, recruiting or not: 13% stop at 75 or younger and 13% at 65; 75% take children; 0% are for women only and 0% for men only; 0% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 8 of 8. search them.
- A Phase 2 Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, in Adults and Children With PIK3CA Related Overgrowth Spectrum and Malformations Driven by PIK3CA Mutation (The ReInspire Study)RecruitingNCT06789913Phase 210 countries
- A Study to Investigate Efficacy and Safety of KP-001 Compared With Placebo in Patients Aged ≥2 Years With Common VM, Common LM, or KTS/CLOVES SyndromeRecruitingNCT07285005Phase 33 countries
- Lymphatic Anomalies Registry for the Assessment of Outcome DataRecruitingNCT023995271 country
- Identification of Biomarkers for Patients with Vascular AnomaliesRecruitingNCT030011801 country
- National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)CompletedNCT055638311 country
- Safety of the Sonablate HIFU System for the Ablation of Incompetent Veins of the PeripheryActive, not recruitingNCT06642051Not applicable1 country
- French National Cohort of Children With Port Wine StainCompletedNCT01364857Not applicable1 country
- Vascular Anomaly Pathology and Genomics Biopsy StudyCompletedNCT04836884Not applicable1 country