Homozygous Familial Hypercholesterolemia: all 68 studies

Page 1 of 1. Open to participants first (13), then studies with results posted, then the rest; newest registration first within each.

• Phase II Clinical Trial to Evaluate the Efficacy and Safety of SYH2070 Injection in Participants With Homozygous Familial HypercholesterolemiaRecruitingNCT07591298Phase 2
• A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory DyslipidemiasRecruitingNCT07491172Phase 1
• A Dose-exploration Study of EDP167 in HoFHRecruitingNCT07489209Phase 2
• Study of Zodasiran in Adolescent Participants With Homozygous Familial HypercholesterolemiaRecruitingNCT07473843Phase 3
• The ORIGIN-FH StudyRecruitingNCT07470723Not applicable
• Assessing the Impact of Intensification of Lipid Lowering Therapy With Guidelines-based Evinacumab Administration on Coronary Plaque Volumes Measured by Coronary Computed Tomography Angiography (CCTA) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)RecruitingNCT07447648
• Evaluate the Long-term Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial HypercholesterolemiaNot yet recruitingNCT07133815Phase 2
• Study to Evaluate Safety, Tolerability and Efficacy of Inclisiran in Children With Homozygous Familial HypercholesterolemiaRecruitingNCT06597006Phase 3
• NGGT006 Gene Therapy for Homozygous Familial HypercholesterolemiaRecruitingNCT06125847Early Phase 1
• Long-term Safety and Tolerability of Inclisiran in Participants With HeFH or HoFH Who Have Completed the Pediatric ORION-16, ORION-13, ORION-20, or ORION-19 StudiesRecruitingNCT05682378Phase 3
• HoFH, the International Clinical Collaborators RegistryRecruitingNCT04815005
• Early Detection of Familial Hypercholesterolemia in ChildrenRecruitingNCT04370899
• The Rogosin Institute Homozygous Familial Hypercholesterolemia RepositoryRecruitingNCT01109368
• Study of ARO-ANG3 in Participants With Homozygous Familial Hypercholesterolemia (HOFH)TerminatedNCT05217667Phase 2Results posted
• Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)CompletedNCT04681170Phase 3Results posted
• Study to Evaluate Efficacy and Safety of Inclisiran in Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT04659863Phase 3Results posted
• Evaluate the Efficacy and Safety of Evinacumab in Pediatric Patients With Homozygous Familial HypercholesterolemiaCompletedNCT04233918Phase 3Results posted
• A Study of Inclisiran in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT03851705Phase 3Results posted
• Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-CCompletedNCT03814187Phase 3Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT03510715Phase 3Results posted
• Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT03409744Phase 3Results posted
• Efficacy and Safety of Evinacumab in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT03399786Phase 3Results posted
• Study in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT03156621Phase 3Results posted
• A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT02963311Phase 2Results posted
• A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)TerminatedNCT02651675Phase 1/2Results posted
• Safety, Tolerability and Efficacy of Evolocumab (AMG 145) in Children With Inherited Elevated Low-density Lipoprotein Cholesterol (Familial Hypercholesterolemia)CompletedNCT02624869Phase 3Results posted
• A Study to Evaluate the Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT02434497Phase 3Results posted
• Study of REGN1500 in Participants With Homozygous Familial Hypercholesterolemia (HoFH)CompletedNCT02265952Phase 2Results posted
• A Study to Evaluate the Efficacy and Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT02226198Phase 3Results posted
• Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering TherapyCompletedNCT02173158Phase 3Results posted
• Gene Analysis and Treatment Optimization in Chinese Homozygous Familial HypercholesterolemiaCompletedNCT01878604Results posted
• Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL DisordersCompletedNCT01624142Phase 2/3Results posted
• Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor AbnormalitiesCompletedNCT01588496Phase 2/3Results posted
• Safety, Tolerability and Efficacy of Microsomal Triglyceride Protein (MTP) InhibitorCompletedNCT01556906Phase 2Results posted
• Vytorin Reexamination Study (0653A-174)CompletedNCT01070966Results posted
• Long Term, Follow-on Study of Lomitapide in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT00943306Phase 3Results posted
• A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)CompletedNCT00730236Phase 3Results posted
• Evaluation of the Safety, Tolerability and Efficacy of Ezetimibe on a Select Population of Filipinos With Hypercholesterolemia (Study P04748)(COMPLETED)CompletedNCT00704535Results posted
• An Open-label Extension Study to Assess the Long-term Safety and Efficacy of ISIS 301012 (Mipomersen) in Patients With Familial Hypercholesterolemia or Severe-HypercholesterolemiaCompletedNCT00694109Phase 3Results posted
• Study to Assess the Safety and Efficacy of ISIS 301012 (Mipomersen) in Homozygous Familial HypercholesterolemiaCompletedNCT00607373Phase 3Results posted
• Open Label Extension of ISIS 301012 (Mipomersen) to Treat Familial HypercholesterolemiaCompletedNCT00477594Phase 2Results posted
• A Phase 3 Study of Zodasiran in Adolescent and Adult Subjects With Homozygous Familial Hypercholesterolemia (YOSEMITE)Active, not recruitingNCT07037771Phase 3
• Evaluation of the Effect of Lomitapide Treatment on Major Adverse Cardiovascular Events (MACE) in Patients With Homozygous Familial HypercholesterolemiaActive, not recruitingNCT06832371
• A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Study Evaluating the Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT06723652Phase 3
• A Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of VSA003 in Chinese HoFH PatientsActive, not recruitingNCT06712771Phase 3
• Specified Drug-use Survey of Leqvio for s.c. Injection.Active, not recruitingNCT06275724
• Evaluate the Efficacy and Safety of SHR-1918 in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT06009393Phase 2
• Safety and Effectiveness of Evinacumab for the Treatment of Homozygous Familial HypercholesterolemiaCompletedNCT05611528Phase 3
• Evaluate the Efficacy and Safety of IBI306 in Subjects With Homozygous Familial HypercholesterolemiaStatus unknownNCT04948008Phase 2/3
• Regeneron 1331 Kinetics Sub-Study HoFHCompletedNCT04722068Not applicable
• Identifying and Genotyping Homozygous Familial Hypercholesterolemia (HoFH) PatientsCompletedNCT04148001
• A Long-term Follow-up Study to Evaluate the Safety and Efficacy of RGX-501Active, not recruitingNCT04080050
• Phase 3 Study to Evaluate the Efficacy and Safety of LIB003 With Evolocumab in HoFHCompletedNCT04034485Phase 3
• A Study to Evaluate Safety and Efficacy of IBI306, a PCSK9 Monoclonal Antibody in Chinese Subjects With Homozygous Familial HypercholesterolemiaCompletedNCT04031742Phase 2/3
• A Study to Evaluate the Safety and Efficacy of the PCSK9 Inhibitor AK102 in Patients With HoFHCompletedNCT03933293Phase 2
• Study of AKCEA-ANGPTL3-LRX (ISIS 703802) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)WithdrawnNCT03455777Phase 2
• Study of cardiovAscular Contrasted Phenotypes in Patients With FamIliaI hypercholesteRolemiaCompletedNCT03234127Not applicable
• HDL Acute Lipid Optimization in Homozygous Familial HypercholesterolemiaStatus unknownNCT03135184Not applicable
• Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication RegistryCompletedNCT03110432
• Evaluate the Efficacy and Safety of Lomitapide in Pediatric Patients With Homozygous Familial Hypercholesterolemia on Stable Lipid-lowering TherapyWithdrawnNCT02765841Phase 3
• Study to Evaluate the Effects of MBX-8025 in Patients With HoFHCompletedNCT02472535Phase 2
• Effects of Lomitapide on Carotid and Aortic AtherosclerosisWithdrawnNCT02399852
• Comparisons of Two Low-density Lipoprotein Apheresis Systems in Patients With Homozygous Familial HypercholesterolemiaCompletedNCT02286596
• LOWER: Lomitapide Observational Worldwide Evaluation RegistryCompletedNCT02135705
• Efficacy and Tolerability of Anacetrapib Added to Ongoing Lipid-Lowering Therapy in Adult Participants With Homozygous Familial Hypercholesterolemia (HoFH) (MK-0859-042)TerminatedNCT01841684Phase 3
• Effect of CER-001 on Plaque Volume in Homozygous Familial Hypercholesterolemia (HoFH) SubjectsCompletedNCT01412034Phase 2
• Dose-escalating Safety Study of ISIS 301012 in Homozygous Familial Hypercholesterolemia Subjects on Lipid Lowering TherapyCompletedNCT00280995Phase 2
• Implitapide in Patients With Homozygous Familial Hypercholesterolemia (HoFH) on Maximal Concurrent Lipid-Lowering TherapyTerminatedNCT00079846Phase 2

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