Failed Back Surgery Syndrome clinical trials
The registry lists 104 studies for Failed Back Surgery Syndrome across more than 10 countries. 17 are recruiting or about to start. 74 of them are mainly about Failed Back Surgery Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Who runs them
Moens Maarten (10) · Universitair Ziekenhuis Brussel (8) · MedtronicNeuro (6) · Poitiers University Hospital (5) · Assiut University (3) · Boston Scientific Corporation (3) · Abbott Medical Devices (3) · University of Michigan (2)
What is being tested here
Drugs under test in Failed Back Surgery Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- May 2027Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal Surgery · Centro Universitário Augusto Motta
- Aug 2027Return to Work for Persistent Spinal Pain Syndrome Type II Patients · Moens Maarten
Who these studies take
Of the 12 Failed Back Surgery Syndrome studies recruiting now, 8 (67%) set no upper age limit and 3 (25%) stop at 75 or younger. 1 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (17%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 1 (8%) |
| 18 | 11 (92%) | 11 (92%) |
| 30 | 12 (100%) | 12 (100%) |
| 40 | 12 (100%) | 12 (100%) |
| 50 | 12 (100%) | 12 (100%) |
| 65 | 11 (92%) | 11 (92%) |
| 75 | 9 (75%) | 9 (75%) |
| 85 | 8 (67%) | 8 (67%) |
Across all 104 studies, recruiting or not: 28% stop at 75 or younger and 9% at 65; 5% take children; 1% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Failed Back Surgery Syndrome studies take
Of 38 interventional studies with no phase under Failed Back Surgery Syndrome, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 23 mo12–38 · 38 studies | — | 23 mo12–52 · 36 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Results posted1
Studies
Recruiting first, then most recently updated. Showing 50 of 104. Browse all 104 → or search them.
- Open and Closed Loop DTM SCS in Patients With PSPS Type 2: ENDLESS StudyRecruitingNCT072113082 countries
- Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study)RecruitingNCT07762170Phase 41 country
- Improvement of Gait by Spinal Stimulation in Patients With Postoperative Chronic Lumbosciatalgia: Pilot Study (GaitStim)RecruitingNCT05857696Not applicable1 country
- Efficacy of Cognitive Functional Therapy in Individuals With Chronic Low Back Pain After Spinal SurgeryNot yet recruitingNCT07576062Not applicable
- Evaluation of Medication Tapering on the Sensitivity of the Spinal Cord Using Closed-Loop Spinal Cord Stimulation (Pilot Study)RecruitingNCT075026121 country
- Effects of Low Back Pain Types on Pain Severity and Quality of Life in Patients With Failed Back Surgery SyndromeRecruitingNCT074889361 country
- Return to Work for Persistent Spinal Pain Syndrome Type II PatientsRecruitingNCT05269212Not applicable1 country
- Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMARecruitingNCT057541901 country
- Effects of Active Versus Passive Recharge Burst Spinal Cord Stimulation on Pain Experience in Persistent Spinal Pain Syndrome Type 2: a Multicenter Randomized Trial (BURST-RAP Study)RecruitingNCT05421273Not applicable1 country
- Differential Target Multiplexed Spinal Cord StimulationRecruitingNCT050680111 country
- Comparing General Anesthesia, General Anesthesia With ESP Block or TLIP Block in Patients Undergoing Lumbar SurgeriesRecruitingNCT05447780Not applicable1 country
- Epidural Pulsed Radiofrequency Treatment in Failed Back Surgery SyndromeNot yet recruitingNCT06239857Not applicable
- SynerFuse Spinal Fusion and Neuromodulation Proof of Concept StudyRecruitingNCT04054401Not applicable1 country
- Effect of Catheter Type on Efficacy of Percutaneous Caudal AdhesolysisNot yet recruitingNCT06051149Not applicable
- The Effect of Mediclore as an Anti-adhesion Agent and Safety in Full-endoscopic Spine Surgery: a Preliminary StudyNot yet recruitingNCT06034041Phase 41 country
- Spinal Cord Stimulation Versus Instrumentation for FBSSRecruitingNCT05466110Not applicable1 country
- Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord StimulationNot yet recruitingNCT057129801 country
- Spinal Cord Stimulation in the Treatment of Chronic, Intractable Pain Using the Nalu™ Neurostimulation SystemCompletedNCT04503109Not applicable1 country
- Burst Spinal Cord Stimulation (Burst-SCS) StudyTerminatedNCT03718325Not applicable1 country
- Caudal Epidural With or Without Lumbar Sympathetic Block for Redo Lumbar SurgeryCompletedNCT07199816Not applicable1 country
- Spinal Cord Stimulation Combined With Exercise in Persistent Spinal Pain SyndromeCompletedNCT06272539Not applicable1 country
- Restoring Segmental Lumbar Lordosis After Failed Previous Fusion at the Same LevelActive, not recruitingNCT07050290Not applicable1 country
- Exploring Neurosphere's Remote Monitoring and Virtual Clinic Features in Improve Quality of Life and Reduce CostsCompletedNCT066475761 country
- Sensory Testing of Multiple Forms of Spinal Cord Stimulation for PainCompletedNCT04732325Not applicable1 country
- Evaluation of Online Tool (E-TOOL SCS) in Spinal Cord StimulaionCompletedNCT062290151 country
- Central Nervous System Amplification in Lumbar Failed Back Surgery SyndromeCompletedNCT034441681 country
- Study on Failed Back Surgery Syndrome Pathway Optimization: A Focus on Patient Identification, Chronicization Factors and Outcome PredictorsCompletedNCT02964130Not applicable1 country
- EuroPainClinicsStudy IX ( EPCS IX )CompletedNCT07411950Not applicable1 country
- Sub-threshold DRG Stimulation vs Sham in Established RespondersCompletedNCT07170722Not applicable1 country
- Subthreshold SCS or BMTActive, not recruitingNCT05169047Not applicable1 country
- Persistent Post-Lumbar Surgery Pain Syndrome (PSPS) Type II is a Common Condition Encountered in Pain Units, With Limited Available Therapeutic Options. Epidural Pulsed Radiofrequency (PRF) Administered Via Catheter Has Demonstrated Greater Efficacy Compared to the Transforaminal Approach. This RandCompletedNCT07156513Not applicable1 country
- Efficacy and Safety of Sodium Hyaluronate Gel Combined With Sodium Bicarbonate Versus Sodium Bicarbonate Alone in Prevention of Failed Back Surgery SyndromeActive, not recruitingNCT06999993Phase 2/31 country
- Caregiver Burden and Correlation With Clinical Outcome in Spinal Cord Stimulation for Chronic Neuropathic PainCompletedNCT047377461 country
- Effectiveness and Safety of Percutaneous Adhesiolysis Using Rac'z Catheter Versus Navi Catheter in Management of Failed Back Surgery SyndromeCompletedNCT05018377Not applicable1 country
- Objective Data on Daily Activity in Patients Treated with SCS: the Intellis StudyCompletedNCT047103554 countries
- High Voltage VS Standard Voltage Radiofrequency in a Patient With Failed Back Surgery SyndromeCompletedNCT05563636Not applicable1 country
- The Effect of Central Sensitization in Radicular Pain in Patients With Failed Low Back Surgery SyndromeCompletedNCT065089181 country
- Intraoperative Neuromonitoring Recording With a Novel SCS Paddle: Phase IICompletedNCT05459324Not applicable1 country
- Coordinated Reset Spinal Cord StimulationWithdrawnNCT04997278Not applicable1 country
- Management of Pain Associated With Failed Back Surgery SyndromeCompletedNCT05324761Phase 41 country
- Intraoperative Neuromonitoring Recording With a Novel SCS PaddleCompletedNCT05045625Not applicable1 country
- Determining the Prognostic Value of Continuous Intrathecal InfusionCompletedNCT03523000Phase 41 country
- Evaluation of an Effectiveness and Safety of the Electroacupuncture in the Management of Intractable Neuropathic PainCompletedNCT03315598Not applicable1 country
- Patient Profiling and Outcome Assessment in Spinal Cord Stimulation for Chronic Back and/or Leg PainStatus unknownNCT053496951 country
- EuroPainClinicsStudy IXCompletedNCT04686903Not applicable1 country
- EuroPainClinics® Study II (Prospective Trial)CompletedNCT02459392Not applicable1 country
- Study Comparing Conventional, Burst and High Frequency (HF) Spinal Cord Stimulation (SCS) in Refractory Failed Back Surgery Syndrome (FBSS) Patients After a 32-contact Surgical Lead ImplantationCompletedNCT03014583Not applicable1 country
- Long Term Follow up of Failed Back Surgery Syndrome(FBSS)CompletedNCT049059271 country
- Epidural Steroid Injections in Post-lumbar Surgery Syndrome After Single-level DiscectomyCompletedNCT05099796Not applicable1 country
- NAPS: Non-awake Versus Awake Placement of Spinal Cord StimulatorsCompletedNCT022845421 country