ClinicalTrials.gg
Not yet recruitingNCT07935304Updated Nov 13, 2026

A Study Assessing Eloralintide (LY3841136) in Healthy Participants

A Phase 1 interventional study of Eloralintide and Eloralintide in Healthy, sponsored by Eli Lilly and Company. Not yet recruiting at 2 sites in 2 countries. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-13.

Sponsored by Eli Lilly and Company · Phase 1, Interventional, and Basic science

Updated Nov 13, 2026Newly registeredGo to Updates ↓

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Phase
Phase 1
Study type
Interventional
Enrollment
90
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The main purpose of this study is to investigate the effects of where Eloralintide is subcutaneously (SC) injected into the body and to investigate how the body processes an intravenous (IV) dose of Eloralintide. Blood tests will be performed to investigate how the study drug affects the body. For each participant, the study will last about 12 weeks and will include a stay in the Clinical Research Unit (CRU) lasting 6 nights.

02

Conditions studied

  • Healthy
03

In context

Lead sponsor

Eli Lilly and Company is the lead sponsor of 2,108 studies on the registry; 153 are open to participants now.

Of its 536 completed or terminated interventional studies of FDA-regulated products, 358 (67%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Are overtly healthy as determined by medical evaluation
  • Are 18 to 65 years of age inclusive, at the time of signing the .
  • Have a (BMI) within the range of 23.0 to 40.0 kilograms per square meter (kg/m²), inclusive.
  • Have had self-reported stable weight for the 3 months prior to screening, that is, less than 5 percent (%) body weight change.

Exclusion criteria

Exclusion Criteria:

  • Have known allergies to related compounds of eloralintide, or any of the components of the formulations.
  • Have been diagnosed with Type 1 or Type 2 diabetes mellitus.
  • Have a history of any within the past 5 years except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of disease for 3 years.
  • Have a history or presence of a gastrointestinal disorder or previous surgery that impacts gastric emptying.
  • Have obesity induced by other endocrinologic disorders, or diagnosed monogenetic or syndromic forms of obesity.
  • Have a history or presence of psychiatric disorders.
  • Have a history of chronic medical conditions involving the heart, liver, or kidneys.
  • Have a history of hypocalcemia or hypercalcemia.
  • Have a medical history or current evidence of cardiac condition.
Terms in these criteria, in plain language(5)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

Cancer (malignancy)

Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.

Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.

Metastases

Cancer that has spread from where it began to other parts of the body. “Metastatic” cancer is cancer that has spread this way.

Clinically significant

Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.

05

Study design

Phase
Phase 1
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
90 participants (estimated)

Study arms

  • Experimental
    Cohort 1: Eloralintide

    Eloralintide administered subcutaneously (SC)

    Drug: Eloralintide

  • Experimental
    Cohort 2: Eloralintide

    Eloralintide administered SC

    Drug: Eloralintide

  • Experimental
    Cohort 3: Eloralintide

    Eloralintide administered SC

    Drug: Eloralintide

  • Experimental
    Cohort 4: Eloralintide

    Eloralintide administered intravenously (IV)

    Drug: Eloralintide

Interventions

06

What researchers measure

Primary outcomes

  1. Pharmacokinetics (PK): Area Under the Plasma Concentration Curve (AUC) of LY3841136 Administered Subcutaneously (SC)

    Time frame: Baseline through Day 57

  2. PK: Maximum Observed Drug Concentration (Cmax) of LY3841136 Administered SC

    Time frame: Baseline through Day 57

Secondary outcomes

  1. PK: AUC of LY3841136 Administered Intravenously (IV)

    Time frame: Baseline through Day 57

  2. PK: Cmax of LY3841136 Administered IV

    Time frame: Baseline through Day 57

07

Study locations

2 sites
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Nov 2026; primary completion for Apr 2027, 5 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 9, 2026
First posted
Nov 13, 2026
StartEst.
Nov 2026
Primary completionEst.
Apr 2027
CompletionEst.
Apr 2027
Last update
Nov 13, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Nov 13, 2026
Show all 1 update
  1. Nov 13, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07935304
Responsible party
Sponsor
First posted
Nov 13, 2026
Start date
Nov 2026 (estimated)
Primary completion
Apr 2027 (estimated)
Completion
Apr 2027 (estimated)
Last update
Nov 13, 2026

Study contacts

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Contact
LillyTrials@Lilly.com
1-317-615-4559
Physicians interested in becoming principal investigators please contact
Contact
clinical_inquiry_hub@lilly.com
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
study director · Eli Lilly and Company

Oversight

Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Nov 2026. You cannot join it, but the record below documents what was studied.

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Discussion

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Studies of the drug tested here: Eloralintide

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