ClinicalTrials.gg
RecruitingNCT07932054Updated Nov 12, 2026

Immune Reconstitution Characteristics and Influencing Factors Following Umbilical Cord Blood Transplantation

An observational study in Transplant-Related Disorder, sponsored by Institute of Hematology & Blood Diseases Hospital, China. Recruiting at 1 site in China. Per ClinicalTrials.gov, last updated 2026-11-12.

Sponsored by Institute of Hematology & Blood Diseases Hospital, China · Observational

Updated Nov 12, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
280
Sex
All
01

Study summary

This study collects immune reconstitution data of umbilical cord blood transplant recipients at multiple time points after transplantation to explore the characteristics and relevant influencing factors of immune reconstitution.

02

Conditions studied

  • Transplant-Related Disorder
03

In context

Lead sponsor

Institute of Hematology & Blood Diseases Hospital, China is the lead sponsor of 412 studies on the registry; 291 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients receiving umbilical cord blood transplant

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. umbilical cord blood transplant;
  2. Patients have to sign an form before the start of the research procedure.

Exclusion criteria

Exclusion Criteria:

Patients who are ineligible for the study due to other factors, or will bear great risk if participating in the study.

Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
280 participants (estimated)
Target follow-up
1 Year
Patient registry
Yes
06

What researchers measure

Primary outcomes

  1. The quantity and diversity of immune cells

    The quantity and diversity of immune cells such as T cells, B cells, and NK cells within one year after transplantation in the overall patients, adult patients, and pediatric patients.

    Time frame: On post-transplant days 30 ± 3, 60 ± 3, 90 ± 3, 120 ± 3, 180 ± 7, 270 ± 7, and 360 ± 7

Secondary outcomes

  1. Incidence of engraftment syndrome

    Incidence of engraftment syndrome in the overall patients, adult patients, and pediatric patients

    Time frame: 1 year post-transplant

  2. Incidence of infections

    Incidence of engraftment syndrome in the overall patients, adult patients, and pediatric patients

    Time frame: 1 year post-transplant

  3. Incidence of relapse

    Incidence of engraftment syndrome in the overall patients, adult patients, and pediatric patients

    Time frame: 1 year post-transplant

  4. Incidence of non-relapse mortality

    Incidence of engraftment syndrome in the overall patients, adult patients, and pediatric patients

    Time frame: 1 year post-transplant

  5. Incidence of graft-versus-host disease

    Incidence of engraftment syndrome in the overall patients, adult patients, and pediatric patients

    Time frame: 1 year post-transplant

  6. survival

    Incidence of engraftment syndrome in the overall patients, adult patients, and pediatric patients

    Time frame: 1 year post-transplant

07

Study locations

1 of 1 sites recruiting
08

References and documents

Study documents

PDFs hosted by the registry, ClinicalTrials.gov.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Oct 2026 (actual). Primary completion is estimated for May 2028, 18 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 6, 2026
First posted
Nov 12, 2026
StartActual
Oct 16, 2026
Primary completionEst.
May 1, 2028
CompletionEst.
May 1, 2029
Last update
Nov 12, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Nov 12, 2026
Show all 1 update
  1. Nov 12, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07932054
Responsible party
Sponsor
First posted
Nov 12, 2026
Start date
Oct 16, 2026
Primary completion
May 1, 2028 (estimated)
Completion
May 1, 2029 (estimated)
Last update
Nov 12, 2026

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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