An interventional study of Air filtration systems without filters (sham) in Cardiovascular (CV) Risk, sponsored by Michigan State University. Recruiting at 1 site in United States. Open to participants aged 21 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-09.
Sponsored by Michigan State University · Not applicable, Interventional, and Basic science
Obesity and exposure to fine particulate matter (particles of aerodynamic diameter less than 2.5 µm, PM2.5) air pollution are established risk factors for cardiovascular (CV) morbidity and mortality. This proposed pilot project seeks to assess interactions between PM2.5 exposure, obesity, CV health, and dietary antioxidant in subjects with obesity.
This proposed intervention study will investigate (1) whether the use of portable air filtration systems (PAFS), by lowering PM2.5 exposures, will improve CV risk factors in subjects with obesity; and (2) whether antioxidant levels will modify the association between PM2.5 exposure and blood pressure. Our project will help validate the benefits of novel strategies to employ PAFS. Positive results would represent a key step in forming the evidence base required to promote more wide-scale PAFS use; in the long term, given their low cost and burden, PAFS use could be up-scaled to help protect diverse populations.
Michigan State University is the lead sponsor of 143 studies on the registry; 27 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants are exposed to unfiltered air (sham) via air filtration systems in the bedroom and main living space of each residence.
Device: Air filtration systems without filters (sham)
Participants were exposed to high-efficiency (HEPA) filtered air via air filtration systems in the bedroom and main living space of each residence.
Device: Air filtration systems without filters (sham)
Subjects were exposed to high-efficiency filtered air.
Brachial blood pressure
Time frame: Daily for 28 days, between 8-10 AM, starting 24 hours after air filtration systems are placed
C-reactive protein
Blood samples for inflammatory marker (high-sensitivity C-reactive protein)
Time frame: Day 1 and Day 28 of each 4-week intervention period.
Carotenoid
non-invasive optical measurement of skin carotenoid levels
Time frame: Day 1 and Day 28 of each 4-week intervention period.
Plan to share: No
No publications or documents are linked to this record.
Started Jun 2025 (actual). Primary completion is estimated for Oct 2026, 16 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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