An observational study in Iron Deficiency Anemia and Parenting Intervention, sponsored by International Centre for Diarrhoeal Disease Research, Bangladesh. Enrolling by invitation at 1 site in Bangladesh. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by International Centre for Diarrhoeal Disease Research, Bangladesh · Observational
The goal of this observational follow-up study is to learn about the long-term effects of early childhood parenting interventions and iron supplementation on young adults in rural Bangladesh. The main questions it aims to answer are:
Do early psychosocial stimulation interventions and iron supplementations lead to sustained improvements in IQ, reduction in mental health and violent behavior into young adulthood?
Does the psychosocial parenting stimulation intervention generate "trickle-down" effects on younger siblings within the same families?
Participants from a previously completed cluster randomized controlled trial conducted in 30 villages in Bangladesh will be invited to participate at approximately 19 years after the original intervention. Young adults aged 20-21 years will undergo assessments of IQ, depressive symptoms, violent behavior, social support-seeking capacity, and hand grip strength. Younger siblings will also be assessed for selected outcomes to examine potential spillover effects of the original parenting intervention.
600 studies on the registry are indexed under Anemia, Iron-Deficiency; 95 are open to participants now.
This study's planned enrollment of 379 is above the median of 200 across 118 observational studies indexed under Anemia, Iron-Deficiency.
Browse Anemia, Iron-Deficiency studies →International Centre for Diarrhoeal Disease Research, Bangladesh is the lead sponsor of 206 studies on the registry; 31 are open to participants now.
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The study population will comprise young adults aged approximately 20-21 years who participated in a previously completed cluster randomized controlled trial conducted in 30 villages in rural Bangladesh. The original trial enrolled children aged 6-24 months, including iron-deficient anemic and non-anemic children, who were assigned to early childhood parenting intervention or no parenting intervention; anemic children received iron supplementation. Approximately 19 years after the original trial, eligible surviving participants who can be traced will be invited to participate in the follow-up study. Immediate adolescent siblings of the original participants aged above 15 years will also be invited to assess potential spillover effects of the early childhood parenting intervention.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Intelligence Quotient (IQ) in Young Adulthood
IQ will be assessed using the Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II). The overall IQ score will be used to evaluate the long-term effects of early childhood psychosocial stimulation and iron supplementation on cognitive functioning in young adulthood.
Time frame: At the 19-year follow-up assessment, when participants are approximately 20-21 years of age.
Depressive Symptoms in Young Adulthood
Depressive symptoms will be assessed using the Patient Health Questionnaire-9 (PHQ-9). For adolescent siblings, depressive symptoms will be assessed using the Patient Health Questionnaire for Adolescents (PHQ-A). Scores will be used to characterize depressive symptom severity.
Time frame: At the 19-year follow-up assessment; participants will be approximately 20-21 years old.
Violent Behavior Traits in Young Adulthood
Violent behavior will be assessed using the Bangla-adapted Buss-Perry Aggression Questionnaire (BPAQ). Questionnaire scores will be used to characterize aggression-related behavior and examine the long-term effects of the original interventions.
Time frame: At the 19-year follow-up assessment, when original trial participants are approximately 20-21 years of age.
Perceived Social Support
Social support will be assessed using the Oslo Social Support Scale. The resulting score will be used to characterize the perceived social support of the participants.
Time frame: At the 19-year follow-up assessment, when original trial participants are approximately 20-21 years of age.
Hand Grip Strength in Young Adulthood
Hand grip strength will be measured using a dynamometer following Southampton protocols. Measurements will be used to characterize participants' physical strength.
Time frame: At the 19-year follow-up assessment, when original trial participants are approximately 20-21 years of age.
Depressive Symptoms and Aggressive Behaviors Among Adolescent Siblings
Depressive symptoms and aggressive behaviors among participants' immediate adolescent siblings aged above 12 years will be assessed using the Patient Health Questionnaire for Adolescents (PHQ-A) and the Bangla-adapted Buss-Perry Aggression Questionnaire (BPAQ), respectively. Outcomes will be examined according to the original parenting intervention exposure to evaluate potential trickle-down effects of the early childhood intervention.
Time frame: At the 19-year follow-up assessment, among eligible immediate adolescent siblings aged above 15 years.
Plan to share: No — We will not share our data to international collaborator. They will help us in manuscript writing only.
Started Sep 2026 (actual). Primary completion is estimated for Nov 2026, 2 months after the start.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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International Centre for Diarrhoeal Disease Research, Bangladesh →