A Phase 1 interventional study of Fluticasone Propionate (FP) 10% Nasal Insert in Chronic Allergic Rhinitis, sponsored by Dianosic. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-05.
Sponsored by Dianosic · Phase 1, Interventional, and Treatment
Phase 1 study designed to evaluate the safety, tolerability and Pharmacokinetic (PK) of a fluticasone propionate (FP) 10% nasal insert in adults suffering from persistent allergic rhinitis. The nasal insert is intended to deliver FP locally. The study will consist of a 4-week treatment period (Main Phase) followed by a 22-week follow-up period (Extension Phase).
717 studies on the registry are indexed under Rhinitis, Allergic; 94 are open to participants now.
This study's planned enrollment of 25 is below the median of 68 across 552 interventional studies indexed under Rhinitis, Allergic.
Browse Rhinitis, Allergic studies →Dianosic is the lead sponsor of 2 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A planned gap after a treatment, so that its effects can lessen before the study treatment or a study assessment. Ask the study team and the doctor who prescribed it before changing any medicine.
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Childbearing potential
Able to become pregnant: from the first period until menopause, unless permanently unable to through surgery (removal of the womb, or of both ovaries or both fallopian tubes).
Criteria for people of childbearing potential usually ask for a negative pregnancy test and for contraception during the study and for a time after it.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Washout period
A planned gap after a treatment, so that its effects can lessen before the study treatment or a study assessment. Ask the study team and the doctor who prescribed it before changing any medicine.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraception
Ways of preventing pregnancy. “Highly effective” methods fail less than 1% of the time a year when used correctly — for example an IUD or an implant.
Criteria usually say which methods count and how long to keep using them after the last dose, sometimes for male participants too. Some studies accept a partner’s vasectomy if it was confirmed successful and that person is the participant’s only sexual partner.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Drug: Fluticasone Propionate (FP) 10% Nasal Insert
Nasal insert containing fluticasone propionate designed for sustained local intranasal delivery
Number of participants with (Serious) Adverse Events over the course of the treatment
Time frame: From Day 0 up to Day 194
Systemic Fluticasone Propionate concentrations
Time frame: From Day 0 up to Day 194
Change from Baseline in Reflective Total Nasal Symptom Score (rTNSS)
The Reflective Total Nasal Symptom Score assesses 4 nasal symptoms, each of them is rated from 0 (none) to 3 (Severe).
Time frame: From Day 0 up to Day 194
Change from Baseline in Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) Score
The Rhinoconjunctivitis Quality of Life Questionnaire assesses quality of life acroos 7 domains using 28 questions. Each item is scored from 0 (Not troubled or None of the time) to 6 (extremely troubled or all of the time).
Time frame: From Day 0 up to Day 180
Change from Baseline in morning cortisol levels
Time frame: From Day 0 up to Day 180
Local Fluticasone Propionate concentrations
Time frame: At Day 28 or at Day 180
Number of participants with procedure-related Adverse Events and device deficiency
Time frame: At Day 0 and Day 1
Insert placement tolerability assessed by Post-Insertion questionnaire
Time frame: At Day 0 and Day 1
No study locations are listed for this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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