ClinicalTrials.gg
RecruitingNCT07915310Updated Nov 4, 2026

Multimodal Assessment of Sarcopenia Using Shear Wave Elastography, Dual-Energy X-ray Absorptiometry, Bioelectrical Impedance Analysis, and Physical Performance Measures

An observational study in Sacropenia, sponsored by Kaohsiung Veterans General Hospital.. Recruiting at 1 site in Taiwan. Open to participants aged 65 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-04.

Sponsored by Kaohsiung Veterans General Hospital. · Observational

Updated Nov 4, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
100
Ages
65 Years and older
Sex
All
01

Study summary

The goal of this observational study is to learn whether shear wave elastography (SWE) parameters, combined with dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), and physical performance assessments, can help diagnose sarcopenia in older adults. The main questions it aims to answer are:

  • Are SWE-derived muscle stiffness parameters associated with muscle mass, muscle strength, and physical performance?
  • Can an integrated model including SWE parameters accurately identify sarcopenia compared with the DXA-based diagnosis?

Researchers will compare participants with sarcopenia to those without sarcopenia, to see if SWE parameters differ between groups and contribute to sarcopenia prediction.

Participants will:

  • Undergo shear wave elastography of selected skeletal muscles
  • Receive a DXA scan to measure appendicular skeletal muscle mass
  • Receive a BIA measurement of body composition
  • Complete muscle strength and physical performance assessments
02

Conditions studied

  • Sacropenia

Keywords

  • Sacropenia
  • DXA
  • Body composition
  • shear wave elastography
  • BIA measurement
  • Geriatrics
03

In context

Lead sponsor

Kaohsiung Veterans General Hospital. is the lead sponsor of 107 studies on the registry; 13 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
65 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Participants will be recruited from the outpatient clinics or inpatient ward of Kaohsiung Veterans General Hospita, Taiwan.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Adults aged 65 years and older
  • Able to walk independently, with or without an assistive device
  • Able to understand study procedures and provide written
  • Able to perform related exam

Exclusion criteria

Exclusion Criteria:

  • Implanted electronic medical devices (e.g., cardiac pacemaker or defibrillator), which contraindicate BIA measurement
  • Metal implants or prostheses in the regions measured by DXA or ultrasound
  • History of fracture or surgery of the lower extremities within the past 6 months
  • Neuromuscular disease affecting skeletal muscle (e.g., stroke with residual limb weakness, Parkinson's disease, myopathy, or amyotrophic lateral sclerosis)
  • Skin lesions, wounds, or infection at the ultrasound measurement sites
  • Acute illness or hospitalization within the past 4 weeks
  • Cognitive impairment or psychiatric conditions that preclude completion of study assessments
  • Inability to complete muscle strength or physical performance tests
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • Sarcopenia

    Participants diagnosed with sarcopenia according to the Asian Working Group for Sarcopenia (AWGS) 2025 consensus, defined as concurrent low muscle strength and low DXA-measured appendicular skeletal muscle mass.

  • Non-sacropenia

    Participants who do not meet the AWGS 2025 criteria for sarcopenia.

06

What researchers measure

Primary outcomes

  1. Diagnostic accuracy of shear wave elastography parameters for sarcopenia

    Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of SWE parameters, alone and combined with BIA and physical performance measures, for identifying sarcopenia as defined by the AWGS 2025 consensus.

    Time frame: Within 2 weeks of enrollment

Secondary outcomes

  1. Appendicular skeletal muscle mass index measured by DXA

    Appendicular skeletal muscle mass divided by height squared (kg/m²), measured by dual-energy X-ray absorptiometry.

    Time frame: Within 2 weeks of enrollment

  2. Skeletal muscle mass index measured by BIA

    Appendicular skeletal muscle mass divided by height squared (kg/m²), measured by bioelectrical impedance analysis.

    Time frame: Within 2 weeks of enrollment

  3. Handgrip strength

    Maximum handgrip strength (kg) of the dominant hand measured with a handheld dynamometer.

    Time frame: Within 2 weeks of enrollment

07

Study locations

1 of 1 sites recruiting
08

References and documents

Publications

  • Chen LK, Hsiao FY, Akishita M, Assantachai P, Lee WJ, Lim WS, Muangpaisan W, Kim M, Merchant RA, Peng LN, Tan MP, Won CW, Yamada M, Woo J, Arai H. A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 Consensus Update. Nat Aging. 2025 Nov;5(11):2164-2175. doi: 10.1038/s43587-025-01004-y. Epub 2025 Nov 4. PubMed 41188603 ↗

Individual participant data

Plan to share: No — Individual participant data will not be shared publicly due to participant privacy and confidentiality requirements under Taiwan's Personal Data Protection Act and the conditions of institutional review board approval. De-identified data may be made available from the corresponding author upon reasonable request, subject to approval by the institutional review board.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Started Oct 2026 (actual). Primary completion is estimated for Dec 2026, 2 months after the start.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 28, 2026
First posted
Nov 4, 2026
StartActual
Oct 21, 2026
Primary completionEst.
Dec 2026
CompletionEst.
Apr 2027
Last update
Nov 4, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Nov 4, 2026
Show all 1 update
  1. Nov 4, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07915310
Responsible party
Ming Hsuan Huang (Attending Physician, Department of Physical Medicine and Rehabilitation, Kaohsiung Veterans General Hospital.) — Principal investigator
First posted
Nov 4, 2026
Start date
Oct 21, 2026
Primary completion
Dec 2026 (estimated)
Completion
Apr 2027 (estimated)
Last update
Nov 4, 2026

Study contacts

Ming Hsuan Huang, MD
Contact
min0711@vghks.gov.tw
+886 073422121

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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