An interventional study of Preoxygenation by Breathing via the tip of a tube hold in the mouth (= Tube Tip In the Mouth (TTIM) and Preoxygenation via Face mask in Preoxygenation, sponsored by Copenhagen University Hospital, Rigshospitalet. Not yet recruiting. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Copenhagen University Hospital, Rigshospitalet · Not applicable, Interventional, and Other
Determining the subjective experience of receiving pre-oxygenation with either a face-mask or with the tip of the tube in the mouth (TTIM = TubeTipIn Mouth)
Background:
Before anesthesia and other procedures the patients are offered additional oxygen. The traditional method is to let the patient breathe oxygen-enriched air or pure oxygen via a face mask for a period of time.
Some patients feel that this procedure is uncomfortable, leads to loss of control or is even claustrophobic.
An alternative is to let the patient breathe a similar oxygeenriched air via a plastic tube that the patient holds in the hand and places in the mouth. This is called Tube Tip In the Mouth (TTIM)
In the study the investigators ask healthy subjects to breathe via a face mask and via a tube in random order.
After having tried this the subject expresses his feeling of comfort/discomfort, of loss of control and of possibe feeling of claustrophobia for each method
Copenhagen University Hospital, Rigshospitalet is the lead sponsor of 39 studies on the registry; 14 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Anesthesiologists participating in an airway course at Rigshosptalet, Copenhagen
Exclusion Criteria:
Un-willingness to participate Contraindication to brief hyperoxia
In this arm the subject receives oxygen via the tip of the tube in the mouth first - followed by via a face mask
Procedure: Preoxygenation by Breathing via the tip of a tube hold in the mouth (= Tube Tip In the Mouth (TTIM)
The subject has preoxygenation via Face mask first
Procedure: Preoxygenation via Face mask
Preoxygenation by Breathing via the tip of a tube hold in the mouth (= Tube Tip In the Mouth (TTIM)
Preoxygenation via Face mask
Comfort
The participants reports on a 10-point scale from 1 = "Not uncomfortable at all" to 10 = Unbearable uncomfortable"
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Feeling of loss of control
The participants reports on a 10-point scale from 1 = "No loss of control" to 10 = "Complete loss of control"
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Feeling of claustrophobia
The participants reports on a 10-point scale from 1 = "no claustrophobia at all to 10 "Unbearable claustrophobia"
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
End expiratory O2 obtained during the preoxygenation
The End expiratory O2 obtained during the preoxygenation as measured via the anaesthesia machine
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Preference of technique
The fraction of participants who prefer the TTIM (Tube Tip In Mouth) preoxygenation method over the face mask method
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Consider TTIM preferable for some patients
The fraction of participants who considers that the TTIM techniques is preferable for some patients
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Considers that TTIM should be the default technique for preoxygenation
The fraction of participants that considers that TTIM should be the default technique for preoxygenation (instead of face mask preoxygenation)
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Would consider implementing TTIM in own practice Yes/no
The fraction of participants who would consider implementing TTIM in his own practice when giving preoxygenation to others in the future
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
Number of encounters that the participating anaesthesiologist in his career has had patients who disliked the mask and would probably have preferred Tube tip in mouth (TTIM) as preoxygenation?
Number of encounters that the participating anaesthesiologist in his career has had patients who disliked the mask and would probably have preferred Tube tip in mouth (TTIM) as preoxygenation?
Time frame: From the start of the preoxygenation-procedure until the end of the preoxygenation-procedure
No study locations are listed for this record.
Plan to share: Yes — The raw data of the results for the primary and seconday outcomes will be shared upon request
Supporting information: Clinical study report
Time frame: The data will be available after publication of the results in a PubMed-indexed journal
Access criteria: Upon request we will send all relevant information
No publications or documents are linked to this record.
Start is estimated for Nov 2026; primary completion for Dec 2026, 1 month later.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Copenhagen University Hospital, Rigshospitalet