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CompletedNCT07912697Updated Nov 3, 2026

Triple Outcome Evaluation of Red Teff Intervention for Infant Anemia, Environmental Health, and Economic Feasibility in Ethiopia: A Self-controlled Pre-post Study

An interventional study of Red teff (Eragrostis teff) porridge in Anaemia, sponsored by Debre Markos University. Completed at 1 site in Ethiopia. Open to participants aged 6 Months to 59 Months. Per ClinicalTrials.gov, last updated 2026-11-03.

Sponsored by Debre Markos University · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Registered 1 year 8 months after the study started (first participant enrolled Feb 2025, registered Oct 2026).
Updated Nov 3, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
32
Allocation
Not applicable
Ages
6 Months to 59 Months
Sex
All
01

Study summary

Background. Childhood anemia affects more than 40% of under-five children in Ethiopia, where iron supplementation has achieved limited success and locally grounded, sustainable strategies are needed. Red teff (Eragrostis tef) is an iron-rich, gluten-free staple crop. We evaluated whether a red teff porridge improves hemoglobin in anemic infants and toddlers, and quantified its cost and potential environmental impact relative to animal-source iron-rich foods.

Methods. In a self-controlled pre-post feeding trial in East Gojjam Zone, Ethiopia, anemic children received 42 g home-prepared red teff porridge providing about 77 mg iron per day for 60 days. The primary outcome, the change in hemoglobin, was analyzed with covariate-adjusted models (n = 32 after excluding one implausible value), with covariates selected on biological grounds and additionally screened by cross-validated LASSO. The cost and greenhouse-gas emissions (GHGE) of red teff were compared with beef, lamb and egg per milligram of absorbed iron and per gram of protein, with substitution and sensitivity analyses.

02

Conditions studied

  • Anaemia

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03

In context

Anemia

1,810 studies on the registry are indexed under Anemia; 215 are open to participants now.

This study's enrollment of 32 is below the median of 117 across 1,336 interventional studies indexed under Anemia.

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Lead sponsor

Debre Markos University is the lead sponsor of 2 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
6 Months to 59 Months
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Chldren diagnosed with anemia.

Exclusion criteria

Exclusion Criteria:

Child who had any physical deformities ,/AIDS, diabetes mellitus and cancer.

Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

HIV

The human immunodeficiency virus, which weakens the immune system.

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05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
32 participants (actual)

Study arms

  • Experimental
    Those children whose Hgb <11 g/dL where an arm group.

    In this study, children were provided with 42 g of porridge prepared from red teff daily for 60 days

    Dietary Supplement: Red teff (Eragrostis teff) porridge

Interventions

  • Dietary supplementRed teff (Eragrostis teff) porridge

    In each household, mothers/caregivers were educated how they prepare porridge made from Red teff (Eragrostis teff). For single serving a total of 50 g of red teff flour was mixed with 50 mL of water in a small plastic bowl to form a slurry, which was then set aside. In a stainless-steel pan, 50 mL of distilled water was boiled. Once the water boiled the slurry was added to the pan and cooked for 15 minutes at 90°C with continuous stirring to prevent coagulation and sticking. After cooking, the porridge was removed from the heat and prepared for child consumption. According to the fact that non-heme iron has a bioavailability of 10-15%, and the recommended daily allowance of iron for children aged 1-3 years is 7 mg/day. In this study, children were provided with 42 g of porridge daily for 60 days.

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What researchers measure

Primary outcomes

  1. mean Hemoglobin level of children

    Time frame: It was assessed after 60 days

07

Study locations

1 site
  • Debre Markos Health Center
    Debre Mark’os, Amhara 269, Ethiopia
08

References and documents

Related links

Individual participant data

Plan to share: No

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Nov 3, 2026
Show all 1 update
  1. Nov 3, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07912697
Lead sponsor
Debre Markos University
Collaborators
Tsinghua University
Responsible party
Melese Linger Endalifer (Assistant Professor, Debre Markos University) — Principal investigator
First posted
Nov 3, 2026
Start date
Feb 9, 2025
Primary completion
Apr 19, 2025
Completion
Apr 19, 2025
Last update
Nov 3, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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