An interventional study of Fluid bolus administration in Kidney Transplant, sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-11-03.
Sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Not applicable, Interventional, and Treatment
The NEPHRON study is a prospective, randomized controlled trial evaluating the use of an automated fluid management system during kidney transplantation. A total of 48 adult patients will be randomly assigned to either an Assisted Fluid Management (AFM) group or a standard care group. The primary objective is to compare the total volume of intravenous fluids administered during surgery. Secondary outcomes include intraoperative hypotension, vasopressor requirements, postoperative kidney function, and complications. The study aims to assess whether AFM-guided therapy can optimize intraoperative fluid administration in kidney transplant recipients.
Kidney transplantation is a treatment for patients with advanced kidney disease. During surgery, maintaining adequate blood pressure and giving the right amount of intravenous fluids are important to support blood circulation and the function of the transplanted kidney.
Giving too much or too little fluid may lead to complications. New monitoring systems can help anesthesiologists decide when patients may benefit from receiving additional fluids.
The aim of the NEPHRON study is to investigate whether a computer-assisted fluid management system can improve the management of intravenous fluids during kidney transplantation compared with standard care.
This study will include 48 adult patients undergoing kidney transplantation at Fondazione Policlinico Universitario A. Gemelli IRCCS in Rome, Italy.
Participants will be randomly assigned to one of two groups. In the first group, anesthesiologists will use a computer-assisted system that provides real-time recommendations about fluid administration. In the second group, anesthesiologists will manage fluid administration using standard blood pressure and circulation monitoring parameters.
The main outcome will be the total amount of intravenous fluids administered during surgery.
The researchers will also compare blood pressure changes, the use of medications to support blood pressure, kidney function after transplantation, urine output, and postoperative complications.
The study aims to determine whether computer-assisted fluid management can help anesthesiologists provide more appropriate fluid treatment during kidney transplantation.
Fondazione Policlinico Universitario Agostino Gemelli IRCCS is the lead sponsor of 952 studies on the registry; 541 are open to participants now.
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age > 18 yo
Exclusion Criteria:
refuse to consent heart failure with \< 35% Severe Cardiac Valvular diseases
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Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
LVEF (left ventricular ejection fraction)
The share of blood the heart’s main pumping chamber (the left ventricle) pushes out with each beat, measured by an echocardiogram (heart ultrasound) or a MUGA scan. About 50–70% is normal.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
fluid will be administered based on the assisted fluid management system
Device: Fluid bolus administration
fluid will be administered based on standard hemodyamic monitoring
fluid challenge will be performed according to artificial intelligence
amount of fluids
Time frame: during syrgery
No study locations are listed for this record.
Plan to share: Yes
No publications or documents are linked to this record.
Start is estimated for Jan 2027; primary completion for Jan 2028, 12 months later.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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