An interventional study of Propolis gel (10%) in Impacted Mandibular Third Molar, sponsored by I Gede Surya Septadinata. Completed at 1 site in Indonesia. Open to participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2026-10-30.
Sponsored by I Gede Surya Septadinata · Not applicable, Interventional, and Treatment
This study evaluated whether propolis could influence salivary alpha-amylase levels following surgical removal of impacted mandibular third molars (lower wisdom teeth). Salivary alpha-amylase is an enzyme that can be measured in saliva and may reflect the body's physiological response to surgical stress.
A total of 26 adults aged 20-40 years who underwent mandibular third molar surgery participated in this randomized controlled trial. Participants were allocated to two groups: 13 received propolis treatment and 13 were assigned to a control group.
Saliva samples were collected on postoperative days 1, 3, and 7 to measure changes in salivary alpha-amylase levels using an enzyme-linked immunosorbent assay (ELISA).
The study aimed to determine whether propolis treatment was associated with different postoperative salivary alpha-amylase patterns compared with the control group. The research was conducted at the Dental and Oral Hospital of Hasanuddin University, Makassar, Indonesia.
This single-center, two-arm randomized controlled trial investigated the effect of propolis treatment on postoperative salivary alpha-amylase levels in patients undergoing mandibular third molar odontectomy.
The study included 26 participants aged 20-40 years who required surgical removal of impacted mandibular third molars classified as Pell and Gregory Class II, Position A. Participants were allocated to a propolis group (n = 13) or a control group (n = 13).
The study used a posttest-only design with repeated postoperative measurements. Saliva samples were obtained on postoperative days 1, 3, and 7. Salivary alpha-amylase concentrations were determined using an enzyme-linked immunosorbent assay (ELISA).
The primary objective was to compare postoperative changes in salivary alpha-amylase levels between the propolis and control groups across the three observation periods.
The clinical procedures were conducted at the Oral and Maxillofacial Surgery Clinic of the Dental and Oral Teaching Hospital, Hasanuddin University, Makassar, Indonesia. Biochemical analysis of saliva samples was performed at the HumRC Laboratory, Faculty of Medicine, Hasanuddin University.
The study received ethical approval under reference number 073/KEPK FKG-RSGM UH/EA/XI/2024.
This is the only study on the registry with I Gede Surya Septadinata as lead sponsor.
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants underwent mandibular third molar odontectomy and received propolis gel as the study intervention. Postoperative salivary alpha-amylase levels were assessed on days 1, 3, and 7.
Drug: Propolis gel (10%)
Participants underwent mandibular third molar odontectomy without receiving the experimental propolis treatment. Postoperative salivary alpha-amylase levels were assessed on days 1, 3, and 7.
Propolis gel was administered as the experimental treatment in participants undergoing mandibular third molar odontectomy.
Salivary Alpha-Amylase Concentration
Salivary alpha-amylase concentration was measured using an enzyme-linked immunosorbent assay (ELISA) in saliva samples collected on postoperative days 1, 3, and 7. Measurements were compared between participants receiving propolis and those in the control group to evaluate differences in postoperative salivary alpha-amylase patterns.
Time frame: Postoperative days 1, 3, and 7
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Propolis