An interventional study of Iron-Folic Acid and Zinc Supplementation and Vitamin C Supplementation in Iron Deficiency Anaemia Due to Dietary Causes, Folic Acid Deficiency Anemia, Dietary and Anemia, sponsored by Patuakhali Science and Technology University. Completed at 1 site in Bangladesh. Open to female participants aged 11 Years to 19 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-29.
Sponsored by Patuakhali Science and Technology University · Not applicable, Interventional, and Prevention
Anemia and iron-folic acid (IFA) deficiencies are major nutritional concerns among adolescent girls in environmentally vulnerable coastal communities of Bangladesh. However, evidence on anemia prevalence and health outcomes in relation to iron-folic acid (IFA) supplement receipt remains limited.
Objectives: This study aimed to assess IFA deficiency-related health problems and the impact of IFA supplementation on hematological, nutritional, and overall health outcomes among adolescent girls in coastal Bangladesh Methods: A randomized controlled trial study was conducted among 440 adolescent girls from Patuakhali, Bagerhat, Noakhali, and Cox's Bazar districts of Bangladesh. In each district, 60 participants were assigned to the IFA intervention group and 60 to the control group. The intervention group received IFA for three months, with assessments of hemoglobin, anemia, nutritional status, and health outcomes.
1,810 studies on the registry are indexed under Anemia; 215 are open to participants now.
This study's enrollment of 440 is above the median of 117 across 1,336 interventional studies indexed under Anemia.
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Only coastal teenage girls between the ages of 11 and 19 who had resided in the study area for at least a year before data collection were included. Participants who provided /assent by legal guardian and were willing to participate in the intervention and also complete the three-month follow-up assessment were included in the study.
Exclusion Criteria:
Participants were excluded if they had severe chronic illnesses or diagnosed medical conditions that could affect on hematological status, were currently receiving iron, folic acid, or other micronutrient-containing supplements/medications, or had incomplete baseline or follow-up data required for analysis
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Arm 1 - Intervention group
Dietary Supplement: Iron-Folic Acid and Zinc Supplementation
Participants received Vitamin C 500 mg daily for three months
Dietary Supplement: Vitamin C Supplementation
Participants received daily capsules containing 47 mg elemental iron, 500 µg folic acid, and 22.5 mg zinc for three months. Adherence and adverse events were monitored.
Participants received Vitamin C 500 mg daily for three months.
Change in Hemoglobin Concentration from Baseline to 3 Months
Change in hemoglobin concentration from baseline to the 3-month follow-up assessment. Hemoglobin concentration will be measured using a calibrated automated hematology analyzer. The change will be calculated as the hemoglobin concentration at 3 months minus the baseline hemoglobin concentration.
Time frame: Baseline to 3 months
Plan to share: No — Individual participant data (IPD) will not be shared with other researchers. The study data will be used for the planned analyses and reporting of study findings. Data sharing may be considered in the future, subject to ethical approval, institutional policies, and protection of participants' confidentiality.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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