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RecruitingNCT07900204Updated Oct 28, 2026

Digestion and Absorption of Postbiotic Regulatory Proteins

An interventional study of Inactivated Probiotics and Placebo in Protein Utilization, sponsored by Wecare Probiotics Co., Ltd.. Recruiting at 1 site in China. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-10-28.

Sponsored by Wecare Probiotics Co., Ltd. · Not applicable, Interventional, and Treatment

Updated Oct 28, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
100
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
All
01

Study summary

The goal of this clinical trial is to find out whether a daily postbiotic supplement can help healthy, physically active adults digest and absorb dietary protein better. The main question we aim to answer is: does taking a postbiotic for 12 weeks increase the levels of essential amino acids in the blood after eating a protein-rich meal? Participants will be randomly assigned to one of two groups. One group will receive the postbiotic supplement, and the other group will receive a placebo (a substance with no active therapeutic effect). Everyone will take their assigned supplement once daily for 12 weeks. During the study, participants will have regular health checks, including body composition and muscle strength tests, provide stool samples, and complete a protein tolerance test with blood samples taken before and after the meal. This study is important because it explores whether a postbiotic can help active adults get more benefit from the protein they eat, potentially offering a new way to support muscle and digestive health.

02

Conditions studied

  • Protein Utilization
03

In context

Lead sponsor

Wecare Probiotics Co., Ltd. is the lead sponsor of 67 studies on the registry; 23 are open to participants now.

Browse Wecare Probiotics Co., Ltd. studies →

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Age: 18-45 years; open to all genders;
  2. Body weight has remained stable over the preceding 3 months (change \< 5%);
  3. Willing to maintain their previous dietary and exercise habits with minimal change during the study period;
  4. Have maintained regular training over the past 3 months, with an average of ≥ 3 sessions/week and each session lasting ≥ 30 minutes;
  5. Voluntarily participate and sign a written form, and be able to complete follow-up visits, blood sampling, stool sampling, and questionnaire completion as required.

Exclusion criteria

Exclusion Criteria:

  1. History of or current presence of severe gastrointestinal disorders (e.g., inflammatory bowel disease, significant malabsorption following gastrointestinal surgery), or other conditions that the investigator deems likely to affect nutrient absorption or the assessment of intestinal parameters;
  2. Use of antibiotics or probiotics within the past 4 weeks;
  3. Use of any protein powder, BCAA, creatine, HMB, etc., within the past 4 weeks;
  4. Use of medications that affect protein metabolism (e.g., , androgenic drugs) within the past 4 weeks;
  5. Presence of severe cardiovascular, hepatic, renal, or metabolic disorders (e.g., uncontrolled hypertension, diabetes mellitus), or conditions that contraindicate participation in the physical performance test;
  6. History of severe musculoskeletal injury or recent surgery within the past 3 months;
  7. Pregnancy or lactation status;
  8. Other conditions under which the investigator deems participation in this study unsuitable, or where adherence to study protocols is unlikely.
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

Corticosteroids (steroids)

Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.

Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
100 participants (estimated)

Study arms

  • Placebo comparator
    Placebo Group

    Dietary Supplement: Placebo

  • Experimental
    Postbiotic group

    Dietary Supplement: Inactivated Probiotics

Interventions

  • Dietary supplementInactivated Probiotics

    Evaluate changes in postprandial plasma essential amino acid response, body composition, muscle-related markers, gut barrier function, and gut microbiota before and after the intervention.

  • Dietary supplementPlacebo

    Placebo

06

What researchers measure

Primary outcomes

  1. Postprandial plasma essential amino acid (EAA) response

    A standardized protein load test

    Time frame: 12 weeks (fasting at 0 min, postprandial at 60 min, and postprandial at 120 min)

07

Study locations

1 of 1 sites recruiting
08

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reached

Start is estimated for Oct 2026; primary completion for Jan 2027, 2 months later.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 21, 2026
First posted
Oct 28, 2026
StartEst.
Oct 14, 2026
Primary completionEst.
Jan 6, 2027
CompletionEst.
Mar 6, 2027
Last update
Oct 28, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 28, 2026
Show all 1 update
  1. Oct 28, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

09

Registry details

Key details

Study ID
NCT07900204
Lead sponsor
Wecare Probiotics Co., Ltd.
Responsible party
Sponsor
First posted
Oct 28, 2026
Start date
Oct 14, 2026 (estimated)
Primary completion
Jan 6, 2027 (estimated)
Completion
Mar 6, 2027 (estimated)
Last update
Oct 28, 2026

Study contacts

Fei Xu
Contact
xu.fei@haut.edu.cn
+ 86 13671979116

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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