An interventional study of Cross-linked sodium hyaluronate 1% and Non-cross-linked low-molecular-weight hyaluronic acid in Wound Healing After Tooth Extraction, sponsored by Cyprus Health and Social Sciences University. Completed at 1 site in Cyprus. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-04.
Sponsored by Cyprus Health and Social Sciences University · Not applicable, Interventional, and Treatment
This study compares early healing after a non-surgical tooth extraction in adults. Participants are assigned by chance to one of three groups: cross-linked hyaluronic acid placed in the extraction site using a gelatin sponge; non-cross-linked hyaluronic acid placed using a gelatin sponge; or a gelatin sponge alone. The study team measures the wound area using photographs at the time of extraction and on days 3, 7, and 14. A clinician who does not know the assigned group also assesses healing. Participants report their pain and use of pain-relief medicine. The study compares healing among the three groups.
Cyprus Health and Social Sciences University is the lead sponsor of 4 studies on the registry; none are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
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Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants receive cross-linked hyaluronic acid delivered via a gelatin sponge after non-surgical tooth extraction.
Drug: Cross-linked sodium hyaluronate 1% · Device: Gelatin sponge
Participants receive non-cross-linked hyaluronic acid delivered via a gelatin sponge after non-surgical tooth extraction.
Device: Non-cross-linked low-molecular-weight hyaluronic acid · Device: Gelatin sponge
Participants receive a gelatin sponge alone after non-surgical tooth extraction.
Device: Gelatin sponge
Cross-linked sodium hyaluronate 1% applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
Non-cross-linked low-molecular-weight hyaluronic acid applied locally to the extraction socket using a gelatin sponge after non-surgical tooth extraction.
Gelatin sponge placed in the extraction socket without hyaluronic acid after non-surgical tooth extraction.
ercentage Reduction in Wound Area
Wound area will be measured from standardized, calibrated clinical photographs using ImageJ. Percentage reduction will be calculated relative to baseline: \[(baseline wound area - follow-up wound area) / baseline wound area\] × 100. Results will be compared among the three groups over time.
Time frame: Postoperative days 0, 3, 7, and 14
Wound Healing Score (WHS)
Clinical wound healing will be assessed using the study's WHS, with a total score ranging from 0 to 9.
Time frame: Postoperative days 3, 7, and 14
Index of Postoperative Recovery (IPR)
Postoperative recovery will be assessed using the IPR measure specified in the study protocol.
Time frame: Postoperative days 3, 7, and 14
Postoperative Pain Intensity
Pain intensity will be recorded using a 10-cm visual analogue scale (VAS), where 0 indicates no pain and 10 indicates the worst pain.
Time frame: Postoperative days 1, 3, and 7
Postoperative Analgesic Consumption
The number of analgesic doses taken by each participant will be recorded in the postoperative medication log.
Time frame: Postoperative days 1-7
Plan to share: No
No publications or documents are linked to this record.
Ran from Oct 2026 to primary completion in Nov 2026, 0 months.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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Cyprus Health and Social Sciences University