An observational study in Male, sponsored by Suleyman Demirel University. Completed at 1 site in Turkey (Türkiye). Open to male participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-26.
Sponsored by Suleyman Demirel University · Observational
The aim of this study evaluate the relationship between sperm count and the second-to-fourth digit ratio (2D:4D) in male patients. Additionally, the associations between body mass index, hormonal profile, hand morphometric measurements, and semen parameters were investigated. Study hypotheses:
H1. There is a significant relationship between the second-to-fourth digit ratio (2D:4D) and sperm count in male patients.
H2. There is a significant relationship between body mass index (BMI) and semen parameters in male patients.
H3. There is a significant relationship between hormonal profile and semen parameters in male patients.
H4. There is a significant relationship between hand morphometric measurements and semen parameters in male patients.
H5. There is a significant relationship between the second-to-fourth digit ratio (2D:4D) and hormonal profile in male patients.
The study was conducted on male individuals who applied to the Suleyman Demirel University Department of Obstetrics and Gynecology. It has been designed as a cross-sectional and prospective study. The parameters to be evaluated in a total of 22 participants (n=22) are: Demographics, BMI, semen parameters, hand measurements, 2D:4D ratios and hormonal data.
Suleyman Demirel University is the lead sponsor of 127 studies on the registry; 36 are open to participants now.
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22
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Exclusion Criteria:
One-time measurements were planned. For each male participant, measurements of the demographics, Body Mass Index (BMI), semen parameters, hand measurements, 2D:4D ratios and hormonal data.
Other: Group 1
The study included male individuals aged 18 years and older. Individuals with a history of index or ring finger fractures, finger injuries, arthritis, gout, or rheumatic diseases affecting the hands or fingers, left-handedness, and lack of semen analysis were excluded.All assessments for this group will be conducted by the doctor.Participation rates and measurements were recorded regularly. For each participant,For each participant, BMI, semen parameters, hand measurements, and 2D:4D ratios were evaluated. Hormonal data were also assessed.
Hand and finger lengths (2d:4d)
Measurements were taken using standardized digital palm photographs taken with the hand placed on a metric surface at a height of 50 cm. The images were analyzed using ImageJ v1.50 software according to international anthropometric protocols (ISAK, WHO, NASA, and the Anthropometric Standardization Reference Guide). Hand length (HL - distance from the wrist crease at the radiocarpal joint to the distal tip of the third finger), hand width (HW - maximum distance between the second and fifth metacarpal heads), wrist width (WW - distance between the radial and ulnar styloid processes), 2D (distance from the metacarpophalangeal crease of the index finger to the fingertip), and 4D (distance from the metacarpophalangeal crease of the ring finger to the fingertip) were measured. The 2D:4D ratio was calculated by dividing the length of the second finger by the length of the fourth finger.
Time frame: Baseline (Day 0)
Semen analysis
Semen samples were collected by masturbation after 2-7 days of sexual abstinence using sterile containers and allowed to liquefy for 30 minutes at 37°C. Ejaculate volume (EjVol) was measured in mL by direct volume assessment and classified as hypospermia (\<1.5 mL), normo-volume (1.5-5 mL), or hyperspermia (\>5 mL). Sperm concentration (SC) was calculated as total sperm count/semen volume and categorized as severe oligozoospermia (\<5 million/mL), mild-moderate oligozoospermia (5-15 million/mL), normozoospermia (15-200 million/mL), or polyspermia (\>200 million/mL).Total motility (ABC) was defined as the percentage of progressive (A+B) and non-progressive (C) motile sperm and classified as severe asthenozoospermia (\<20%), moderate motility impairment (20-39%), borderline normal motility (40-60%), and good motility (\>60%). Progressive motility (PM) was evaluated as severe (\<10%), reduced (10-31%), normal (32-50%), or good (\>50%).
Time frame: Baseline (Day 0)
Hormone analysis
Hormone levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) from fasting venous serum samples, and the relationships between hand/finger lengths and ratios were evaluated.Hormonal evaluation included the examination of folic acid (FA), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), and total testosterone (TT) levels.
Time frame: Baseline (Day 0)
Plan to share: No — The data for objectives of the research will be compared after they are received.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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