An observational study in Hemolytic Anemia, Thalassemia and Iron Overload, sponsored by Assiut University. Not yet recruiting. Open to participants aged 7 Years and older. Per ClinicalTrials.gov, last updated 2026-10-20.
Sponsored by Assiut University · Observational
This cross-sectional study aims to evaluate the diagnostic performance of native T1 mapping and extracellular volume fraction for the detection of myocardial iron overload and fibrosis in patients with chronic hemolytic anemia compared with T2* relaxometry.
Patients with transfusion-dependent chronic hemolytic anemia are at risk of myocardial iron overload and fibrosis. Cardiovascular magnetic resonance T2* is the reference method for iron quantification, but native T1 mapping and extracellular volume may provide complementary information.
This observational study will perform cardiac magnetic resonance including native T1 mapping, T2*, post-contrast T1 for extracellular volume calculation, and late gadolinium enhancement in patients aged 7 years or older with chronic hemolytic anemia.
87 studies on the registry are indexed under Anemia, Hemolytic; 26 are open to participants now.
This study's planned enrollment of 54 is below the median of 105 across 24 observational studies indexed under Anemia, Hemolytic.
Browse Anemia, Hemolytic studies →Assiut University is the lead sponsor of 5,050 studies on the registry; 2,174 are open to participants now.
Of its 14 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients aged 7 years or older with confirmed transfusion-dependent chronic hemolytic anemia referred for cardiac magnetic resonance at Assiut University Hospitals.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with transfusion-dependent chronic hemolytic anemia undergoing cardiac magnetic resonance with native T1 mapping, T2\*, and extracellular volume assessment.
Native T1 value
Mean global native T1 value in milliseconds measured by modified Look-Locker inversion recovery sequence.
Time frame: Baseline
Extracellular volume fraction
Mean global extracellular volume fraction calculated from native and post-contrast T1 values corrected for hematocrit.
Time frame: Baseline
T2* value
Mean mid-septal T2\* value in milliseconds.
Time frame: Baseline
Number of patients with myocardial iron overload
Number of patients with T2\* less than 20 milliseconds.
Time frame: Baseline
Number of patients with late gadolinium enhancement
Number of patients showing late gadolinium enhancement on post-contrast images.
Time frame: Baseline
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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