An interventional study of In-Person Group Singing and instructional sing-along video series in Elderly and Coronary Arterial Disease (CAD), sponsored by Medical College of Wisconsin. Not yet recruiting at 1 site in United States. Open to participants aged 55 Years to 89 Years. Per ClinicalTrials.gov, last updated 2026-10-19.
Sponsored by Medical College of Wisconsin · Not applicable, Interventional, and Other
Unlike traditional physical exercise, the impact of singing on cardiovascular health has not been extensively studied. Endothelial dysfunction predicts cardiovascular events, and physical exercise improves vascular endothelial function. In a rigorously conducted randomized, cross-over control study, our team is the first to demonstrate that 30 minutes of solo singing improves endothelial function acutely, regardless of singing expertise. Changes were more robust in subjects with baseline endothelial dysfunction (i.e., those with established coronary artery disease). The improvements occurred in microvascular, but not macrovascular, endothelial function. The observed change in microvascular function translates into a \~25% reduction in cardiovascular disease (CVD) risk, which is comparable to traditional cardiac rehabilitation program participation.
Based on our prior research, the overall objective of the planned future RCT is to test our central hypothesis that habitual singing over several weeks, similar to habitual exercise, will lead to sustained and favorable vascular adaptation, thereby lowering CVD risk. The overall objective of this project, titled "GrOup singing or solo singing To improve Vascular health in Older adults wIth Coronary artery disEase (GOT VOICE): A Feasibility Study", is to refine and protocolize the singing interventions and test the feasibility of our future trial design.
Medical College of Wisconsin is the lead sponsor of 546 studies on the registry; 120 are open to participants now.
Of its 74 completed or terminated interventional studies of FDA-regulated products, 57 (77%) have results posted.
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Exclusion Criteria:
Group singing sessions are conducted in an in-person format. Intake forms will be used to assess musical preference, prior music experience, and pertinent medical conditions to consider. Songs will be selected based on music preference of the subjects. At the start of each session, the music therapist will review the importance of singing and lead the group in taking deep breaths together. Throughout sessions, the therapist will encourage subjects to sing as much as possible, explaining that it's not about how they sound but how they feel. Initially, the group singing format will be 40 minutes of singing (includes a vocal warm-up), three times weekly, for a total of 12 weeks. The total singing time is the same as in the solo singing video arm. Based on focus group feedback, the formats could change. However, we will aim to keep total singing time the same (i.e., 120 minutes of singing per week). Each week, the group will also get a health education document to review.
Behavioral: In-Person Group Singing
Participants in this arm watch and sing to an online video series independently. The video series is created by a professor of voice with older students in the videos. We plan to use REDCap to deliver the assigned videos at set times and frequencies and display the videos in an embedded audio player for the subjects. Use of REDCap will allow us to track when subjects are watching the videos with reminders sent up to five times. We will also include 2 questions at the end on how much they enjoyed the video (scale 1-10) and how much of the 40 minutes were sung. Inserting questions at the end confirms that participants likely viewed the entire video. Each week, the group will also get a health education document to review.
Behavioral: instructional sing-along video series
Participants receive a weekly health education document to review.
Behavioral: Weekly health education
12-weeks of group singing in-person, 3 times weekly with additional weekly health education
12-week solo singing video series done independently, 3 times weekly with additional weekly health education
One health education topic will be provided for participants to review weekly in the form of a document
Participant adherence
Participant attendance (out of 36 total sessions) by those enrolled
Time frame: 12 weeks
Retention rate
Proportion of enrolled subjects who complete all 3 study visits during the 6 months of study participation.
Time frame: 6 months
Dropout rate (acceptability)
Percent of enrolled subjects who drop out of study participation during the 12 weeks of active study participation
Time frame: 12 weeks
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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