An interventional study of Microscope-Assisted Endodontic Surgery in Periapical Lesions, sponsored by University of Medicine and Pharmacy at Ho Chi Minh City. Completed at 2 sites in Vietnam. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by University of Medicine and Pharmacy at Ho Chi Minh City · Not applicable, Interventional, and Treatment
This study aimed to evaluate clinical and periapical radiographic healing following endodontic surgery using a surgical microscope.
An uncontrolled longitudinal clinical intervention study was conducted in patients requiring endodontic surgery. All surgical procedures were performed using a surgical microscope, ultrasonic instruments, and mineral trioxide aggregate (MTA) root-end filling.
Postoperative healing was evaluated through clinical examinations and periapical radiographs at scheduled follow-up visits over a 3-month period. The study assessed clinical healing, radiographic healing, changes in periapical radiolucency, and overall treatment success.
University of Medicine and Pharmacy at Ho Chi Minh City is the lead sponsor of 121 studies on the registry; 41 are open to participants now.
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All participants underwent microscope-assisted endodontic surgery for teeth with periapical lesions and were followed for 3 months to assess clinical and radiographic healing.
Procedure: Microscope-Assisted Endodontic Surgery
Endodontic surgery was performed under a surgical microscope. The procedure included flap elevation, ultrasonic osteotomy, removal of periapical inflammatory tissue, resection of the apical 3 mm of the root, ultrasonic preparation of a 3-mm-deep root-end cavity, and root-end filling with MTA Repair HP. The surgical flap was repositioned and sutured.
Clinical Healing
Clinical healing was assessed according to the criteria of Gutmann and Harrison (1994) and classified into three categories: complete, uncertain, and unsatisfactory healing. Complete healing was defined as the absence of pain, infection, swelling, sinus tract, tenderness on palpation or percussion, tooth mobility, periodontal pocket communication with the root apex, and adverse effects on adjacent teeth. Uncertain healing was defined by at least one of the following: vague intermittent symptoms, pressure or swelling sensation at the surgical site, mild pain on palpation, percussion, or chewing, or discomfort when applying pressure with the tongue. Unsatisfactory healing was defined by at least one of the following: severe pain, infection, swelling, sinus tract, severe tenderness on palpation or percussion, tooth mobility, periodontal pocket communication with the root apex, or adverse effects on adjacent teeth.
Time frame: 1 and 3 months after surgery
Radiographic Healing
Periapical radiographic healing was assessed using study-defined criteria based on Rud (1972) and Molven (1987). Three components were evaluated: the apical periodontal ligament space and lamina dura, periapical radiolucency, and bone regeneration. Healing was classified as complete (restoration of a continuous lamina dura and complete bone regeneration), incomplete (reduced radiolucency with bone regeneration, irregular margins, and an asymmetric radiolucency separated from the periodontal ligament space), uncertain (reduced, round or semicircular radiolucency continuous with the periodontal ligament space), or unsatisfactory (unchanged or increased radiolucency). Complete healing required all three components to be complete; incomplete healing required at least one incomplete component with all others complete; uncertain healing required at least one uncertain component and no unsatisfactory component; and unsatisfactory healing required at least one unsatisfactory component.
Time frame: 1 and 3 months after surgery
Plan to share: No
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Ran from Jul 2024 to primary completion in Jul 2025, 12 months.
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This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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