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Not yet recruitingNCT07875855Updated Oct 15, 2026

MRI-Based Artificial Intelligence Prediction of Fluoroscopic C-Arm Angles for Lumbar Transforaminal Epidural Steroid Injections

An observational study in Lumbar Radicular Pain and Artifical Intelligence, sponsored by Marmara University. Not yet recruiting. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-10-15.

Sponsored by Marmara University · Observational

Updated Oct 15, 2026Newly registeredGo to Updates ↓
Study type
Observational
Model
Other
Time perspective
Prospective
Enrollment
80
Ages
18 Years to 75 Years
Sex
All
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Study summary

This study aims to prospectively evaluate the accuracy of artificial intelligence (AI) in predicting fluoroscopic C-arm oblique and craniocaudal angles from pre-procedural lumbar magnetic resonance (MR) images for lumbar transforaminal epidural steroid injections (TFESI). The AI predictions will be compared to the final reference C-arm angles determined by an experienced operator during the procedure.

Read the detailed description

Lumbar transforaminal epidural steroid injection (TFESI) is an interventional pain treatment commonly used for lumbar radicular pain. It requires appropriate fluoroscopic visualization of the targeted nerve root and neural foramen to safely advance the needle. During the procedure, the fluoroscopic C-arm must be positioned at appropriate oblique and craniocaudal angles to optimally visualize the target anatomical structures. The required C-arm angles vary among patients due to individual anatomical features such as vertebra and pedicle morphology, facet joint structure, vertebral rotation, and lumbar lordosis. Currently, these angles are determined based on operator experience and sequential fluoroscopic images, often requiring multiple repositioning attempts and additional radiation exposure. Since many patients undergo lumbar MR imaging prior to TFESI, utilizing anatomical information from these existing images could help predict patient-specific initial C-arm angles. This study will use an AI-based system (ChatGPT) to evaluate standard T2-weighted lumbar MR images and predict the optimal oblique and craniocaudal C-arm angles. The operating physician will be blinded to the AI predictions and will determine the C-arm positioning based solely on their clinical evaluation. The study aims to evaluate whether AI can accurately predict these angles and to determine if prediction accuracy varies based on the target lumbar level and patient characteristics.

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Conditions studied

  • Lumbar Radicular Pain
  • Artifical Intelligence

Keywords

  • Lumbar Transforaminal Epidural Steroid Injection (TFESI)
  • Artificial Intelligence.
  • Fluoroscopic C-arm Angles
  • Lumbar MRI
03

In context

Lead sponsor

Marmara University is the lead sponsor of 590 studies on the registry; 135 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

dult patients scheduled for unilateral or bilateral, single or multi-level TFESI due to lumbar radicular pain as part of routine clinical practice.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Being between 18-75 years of age.
  • Scheduled for TFESI due to lumbar radicular pain as part of routine clinical practice based on clinical and imaging findings.
  • Planned for unilateral or bilateral, single or multi-level TFESI.
  • Having appropriate quality lumbar MR images obtained within the last 6 months prior to the procedure.
  • Providing written informed consent.

Exclusion criteria

Exclusion Criteria:

  • History of spinal surgery at the target lumbar level that could significantly alter anatomy and fluoroscopic imaging (e.g., instrumentation, fusion, or significant bone resection).
  • Presence of severe scoliosis or structural spinal deformity affecting the standard TFESI technique or standard fluoroscopic projections.
  • Significant motion, metal, or other imaging artifacts on lumbar MR images.
  • Inadequate quality of any of the pre-defined standardized sagittal, parasagittal, or axial T2-weighted images in the current MRI examination.
  • Inability to perform or cancellation of the planned TFESI procedure for any reason.
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Study design

Observational model
Other
Time perspective
Prospective
Enrollment
80 participants (estimated)
Target follow-up
3 Weeks
Patient registry
Yes

Interventions

  • OtherAI based evaluation

    AI-based evaluation of pre-procedural T2-weighted lumbar MR images to predict optimal fluoroscopic C-arm angles (oblique and craniocaudal)

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What researchers measure

Primary outcomes

  1. The absolute error (in degrees) between the AI-predicted oblique and craniocaudal C-arm angles and the reference angles determined by the operator during the procedure

    The absolute error (in degrees) between the AI-predicted oblique and craniocaudal C-arm angles and the reference angles determined by the operator during the procedure

    Time frame: Baseline

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Study locations

No study locations are listed for this record.

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References and documents

Study documents

  • Protocol and statistical analysis plan · Oct 11, 2026

Documents are hosted by the registry — open the source record to download them.

09

Updates

1 registry update since Sep 25, 2026
Registered
First appeared on the registry. No changes since
Oct 15, 2026
Show all 1 update
  1. Oct 15, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

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Registry details

Key details

Study ID
NCT07875855
Lead sponsor
Marmara University
Responsible party
Halis Uğur (Resident Physician, Marmara University) — Principal investigator
First posted
Oct 15, 2026
Start date
Dec 1, 2026 (estimated)
Primary completion
May 1, 2027 (estimated)
Completion
Dec 1, 2027 (estimated)
Last update
Oct 15, 2026

Study contacts

Savaş Şencan, Assoc. Prof. of Algology, M.D
Contact
savas-44@hotmail.com
+905370665713
Halis Uğur, Resident Physician, M.D.
Contact
halis.ugur.93@gmail.com
+905531363454

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.

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