An interventional study of Erector spinae plane block with 10 ml of 0.25% isobaric bupivacaine and Erector spinae plane block with 20 ml of 0.25% isobaric bupivacaine in Equivalent Concentrations, Different Volumes and Bupivacaine, sponsored by Mansoura University. Completed at 1 site in Egypt. Open to female participants aged 25 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-10-13.
Sponsored by Mansoura University · Not applicable, Interventional, and Treatment
This study aimed to compare and evaluate the efficiency of different volumes and equivalent concentrations of bupivacaine in erector spinae plane block in reducing the Postoperative pain after modified radical mastectomy.
Breast cancer is the most common cancer among women all over the world . Acute Postoperative pain is an integrated risk factor for the development of chronic post-mastectomy pain where 40% of women after breast cancer surgery will have severe acute Postoperative pain and 50% will develop chronic post-mastectomy pain with impaired quality of life.
The erector spinae plane block (ESPB) is a new technique that has been recently described in the control of chronic pain with neuropathic component of the chest wall and for pain control in thoracoscopic surgery.
Mansoura University is the lead sponsor of 1,115 studies on the registry; 184 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Patients received rector spinae plane block with 10 ml of 0.25% isobaric bupivacaine
Drug: Erector spinae plane block with 10 ml of 0.25% isobaric bupivacaine
Patients received rector spinae plane block with 20ml of 0.25% isobaric bupivacaine
Drug: Erector spinae plane block with 20 ml of 0.25% isobaric bupivacaine
Patients received erector spinae plane block with 10 ml of 0.25% isobaric bupivacaine
Patients received erector spinae plane block with 20 ml of 0.25% isobaric bupivacaine
Total analgesic requirements
An additional dose of 25 µg IV fentanyl was given if visual analog scale (VAS)\>3.
Time frame: 24 hours postoperatively
Time of first analgesic request
Time of first analgesic request was recorded from the end of surgery till first dose of fentanyl consumption
Time frame: 24 hours postoperatively
Degree of pain
Each patient will be instructed about postoperative pain assessment with the visual analogue score (VAS). VAS (0 represents "no pain" while 10 represents "the worst pain imaginable").
Time frame: 24 hours postoperatively
Heart rate
Heart rate was recorded from every 15 minutes till 24 hours postoperatively
Time frame: 24 hours postoperatively
Mean arterial blood pressure
Mean arterial blood pressure was recorded from every 15 minutes till 24 hours postoperatively
Time frame: 24 hours postoperatively
Incidence of postoperative complications
Incidence of postoperative complications like nausea, vomiting, respiratory depression, and pneumothorax were recorded.
Time frame: 24 hours postoperatively
Plan to share: Yes — The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
Supporting information: Study protocol
Time frame: After the end of study for one year.
Access criteria: The data will be available upon a reasonable request from the corresponding author.
No publications or documents are linked to this record.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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