An interventional study of Subfascial Endoscopic Perforator Surgery(SEPS) and Open Perforator Ligation(Stab Avulsion) in Varicose Veins of Lower Limb, sponsored by King Edward Medical University. Recruiting at 1 site in Pakistan. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2026-10-14.
Sponsored by King Edward Medical University · Not applicable, Interventional, and Treatment
The goal of this study is to compare two surgical treatments for lower limb varicose veins: subfascial endoscopic perforator surgery (SEPS) and open perforator ligation. Patients undergoing treatment for lower limb varicose veins will receive one of these surgical procedures. The study will compare postoperative outcomes, recovery, and complications between the two groups to determine which surgical approach provides better outcomes.
King Edward Medical University is the lead sponsor of 80 studies on the registry; 25 are open to participants now.
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Exclusion Criteria:
Participants in this group will undergo subfascial endoscopic perforator surgery (SEPS) for treatment of incompetent perforator veins associated with lower limb varicosities. The procedure involves endoscopic identification and division of incompetent perforating veins through small incisions, with the aim of reducing venous reflux and improving clinical outcomes.
Procedure: Subfascial Endoscopic Perforator Surgery(SEPS)
Participants in this group will undergo conventional open surgical ligation(Stab Avulsion) and division of incompetent perforating veins for treatment of lower limb varicosities. The clinical and postoperative outcomes will be compared with those of participants undergoing SEPS.
Procedure: Open Perforator Ligation(Stab Avulsion)
Participants in this group will undergo subfascial endoscopic perforator surgery (SEPS) for treatment of incompetent perforator veins associated with lower limb varicosities. The procedure involves endoscopic identification and division of incompetent perforating veins through small incisions, with the aim of reducing venous reflux and improving clinical outcomes.
Participants in this group will undergo conventional open surgical ligation(Stab Avulsion) and division of incompetent perforating veins for treatment of lower limb varicosities. The clinical and postoperative outcomes will be compared with those of participants undergoing SEPS
Venous Clinical Severity Score
Change in Venous Clinical Severity Score (VCSS) from baseline to postoperative follow-up will be assessed to compare clinical improvement between patients undergoing subfascial endoscopic perforator surgery and open perforator ligation.
Time frame: 1 and 2 months follow up
Recurrence of Lower Limb Varicosities
Presence of recurrent varicosities in the treated limb during follow-up after surgery.
Time frame: 1 month
Postoperative Wound Complications
Occurrence of wound infection, wound dehiscence, hematoma, or delayed wound healing following surgery.
Time frame: Within 30 days after surgery
Visual Analogue Scale for Pain
Postoperative pain will be assessed using the Visual Analogue Scale (VAS), with pain intensity recorded at follow-up and compared between the subfascial endoscopic perforator surgery and open perforator ligation groups.
Time frame: 24 hours
Started Jul 2026 (actual). Primary completion is estimated for Dec 2026, 5 months after the start.
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From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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King Edward Medical University