An observational study in Acute Respiratory Failure (ARF), sponsored by Izmir Katip Celebi University. Completed at 1 site in Turkey (Türkiye). Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Izmir Katip Celebi University · Observational
Acute respiratory failure is a condition in which the lungs cannot provide enough oxygen or remove enough carbon dioxide from the blood. Noninvasive ventilation supports breathing through a mask. However, this treatment may not provide enough support for some patients.
This study aims to evaluate whether work of breathing (WOB), which describes the effort needed to breathe, can help predict noninvasive ventilation failure in patients with acute respiratory failure. WOB assessments will be compared between patients in whom noninvasive ventilation succeeds and those in whom it fails. The findings may help healthcare professionals identify patients who are less likely to benefit from this treatment and may need closer monitoring or additional breathing support.
1,721 studies on the registry are indexed under Emergencies; 335 are open to participants now.
This study's enrollment of 200 is below the median of 351 across 726 observational studies indexed under Emergencies.
Browse Emergencies studies →Izmir Katip Celebi University is the lead sponsor of 198 studies on the registry; 41 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Adults aged 18 years or older presenting to the emergency department with acute respiratory failure of any etiology for which noninvasive mechanical ventilation is indicated. Patients meeting the study eligibility criteria will undergo work of breathing (WOB) assessment at NIV initiation and 2 hours after initiation and will be followed until hospital discharge or in-hospital death to determine whether endotracheal intubation becomes necessary despite NIV treatment.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Patients with acute respiratory failure receiving noninvasive ventilation as part of routine clinical care. Work of breathing (WOB) will be assessed to evaluate its ability to predict noninvasive ventilation failure. Patients will be followed until hospital discharge or in-hospital death, whichever occurs first. WOB findings will be compared between patients with noninvasive ventilation success and those with noninvasive ventilation failure.
Noninvasive Ventilation Failure Requiring Endotracheal Intubation
Noninvasive ventilation (NIV) failure is defined as the development of a clinical need for endotracheal intubation despite NIV treatment. Work of breathing (WOB) will be assessed at NIV initiation and 2 hours after initiation. The predictive performance of WOB at each assessment time point for NIV failure will be evaluated.
Time frame: From NIV initiation until hospital discharge or in-hospital death, whichever occurs first; WOB assessed at NIV initiation and 2 hours.
Plan to share: No — There is currently no plan to share individual participant data with other researchers. Study findings will be disseminated through scientific publications and presentations using aggregate data.
Ran from May 2024 to primary completion in Sep 2026, 28 months.
Of 310 non-industry observational studies under Emergencies, half reached primary completion within 14 months of starting (the median), counting those still running; a quarter within 5 and three quarters within 30. This study's 28 months is above that.
Counting every sponsor, half of 321 studies reached it within 14 months; a quarter within 5 and three quarters within 30.
Emergencies covers many different conditions, not one, so the studies compared here vary widely. Read these figures as a rough guide.
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.
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