An interventional study of electromyography (EMG) of genioglossus (GG) in Invasive Mechanical Ventilation and Extubation Time, sponsored by Fondazione IRCCS Policlinico San Matteo di Pavia. Not yet recruiting at 1 site in Italy. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-25.
Sponsored by Fondazione IRCCS Policlinico San Matteo di Pavia · Not applicable, Interventional, and Other
Muscle activity in the upper airway is influenced by specific states such as anesthesia, sleep, wakefulness, and the phases of respiration. The hypoglossal nerve, which innervates the genioglossus muscle, receives input from the brain's sleep-wake center, respiratory pattern-generating neurons, chemoreceptors, and airway negative pressure receptors. Preliminary activation of the genioglossus muscle and other upper airway dilators by the hypoglossal nerve occurs approximately 50-200 ms before innervation of the phrenic motor neurons and the subsequent action of the diaphragm. The forward movement of the genioglossus increases the stiffness and diameter of the upper airway, effectively counteracting collapse forces during inspiration. Assessing genioglossus function could prove critical in determining the optimal timing for extubation. This requires a methodology to evaluate the upper airway by measuring genioglossus activity in intubated patients. In the future, this could provide an objective measure for assessing suitability for extubation. This study explores a method for measuring the electrical activity of the upper airway muscles and the diaphragm in ventilated patients and correlates the results in a systematic view.
Fondazione IRCCS Policlinico San Matteo di Pavia is the lead sponsor of 257 studies on the registry; 114 are open to participants now.
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Procedure: electromyography (EMG) of genioglossus (GG)
Measurement of efferent neural drive from respiratory centers to upper airways using electromyography (EMG) of genioglossus (GG) in patients dependent on invasive mechanical ventilation
Proportion (with 95% confidence intervals) of participants meeting the stimulation success criterion.
Proportion (with 95% confidence intervals) of participants meeting the stimulation success criterion.
Time frame: 6 months
Proportion completing each measurement (Baseline - initial, Challenge, Baseline - subsequent).
Proportion completing each measurement (Baseline - initial, Challenge, Baseline - subsequent).
Time frame: 6 months
Change in GG-EMG amplitude from baseline to physiological challenge quantified as RMS or peak-to-peak
Change in GG-EMG amplitude from baseline to physiological challenge quantified as RMS or peak-to-peak
Time frame: between Day 1 and Day 3 recordings
Change in GG-EMG amplitude between Day 1 and Day 3 recordings
Change in GG-EMG amplitude between Day 1 and Day 3 recordings
Time frame: 1-3 days
Correlation of EMG metrics and clinical variables (e.g., sedation depth, PCO₂, neurological status)
Correlation of EMG metrics and clinical variables (e.g., sedation depth, PCO₂, neurological status)
Time frame: 6 months
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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