An Early Phase 1 interventional study of Leukocyte Platelet Rich Fibrin in Partially Edentulous Maxilla, sponsored by The University of Texas Health Science Center at San Antonio. Not yet recruiting at 1 site in United States. Open to participants aged 18 Years to 85 Years. Per ClinicalTrials.gov, last updated 2026-09-23.
Sponsored by The University of Texas Health Science Center at San Antonio · Early Phase 1, Interventional, and Treatment
An examination of the participants mouth is done first. If they do not have enough bone to place a dental implant as a tooth replacement, and they have chosen sinus augmentation to treat this issue during implant placement a leukocyte platelet rich fibrin (L-PRF) will be performed instead of using other available options. The only difference from usual care is that L-PRF alone will be used as the bone formation material and two additional x-rays, Cone Beam Computed Tomography (CBCTs) will be taken right after the procedure and then again six months after treatment. CBCT is a special type of 3D X-ray commonly used in dentistry and oral surgery. Unlike traditional X-rays, which create flat 2D images, CBCT produces detailed 3D images of your teeth, jawbone, nerves, and nearby tissues.
Prior to surgery, a detailed radiographic assessment is performed utilizing a limited volume CBCT and periapical radiographs (PA). During the implant planning phase, a careful evaluation of the implant's positioning and angulation will be conducted based on the preoperative CBCT images. On the day of the surgical appointment, following local anesthetic administration, a full-thickness flap is elevated, facilitating access and visibility for a comprehensive assessment of the alveolar ridge and the specific site designated for implant placement. A closed sinus augmentation will be performed. Upon completion of the infracture of the sinus floor, L-PRF will be introduced into the osteotomy and precisely propelled into the sinus. Implants placement will follow placement of the L-PRF.
Exclusion Criteria:
Partially edentulous patients requiring maxillary sinus augmentation for dental implant placement
Biological: Leukocyte Platelet Rich Fibrin
L-PRF does not directly induce bone formation within the maxillary sinus; rather, it serves as an autologous biologic scaffold that facilitates the regenerative process
Also known as: L-PRF
Maxillary Sinus Volume using 2D imaging
Regular x-rays are used to take measurements
Time frame: Baseline to 6 months
Maxillary Sinus Volume using 3D imaging
3D CBCT images are used for measurements
Time frame: Baseline to 6 months
Plan to share: Yes — At the end of the study, all study databases will be de-identified and archived at the Graduate Periodontics UT Health San Antonio.
Supporting information: Study protocol, Sap
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This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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The University of Texas Health Science Center at San Antonio