An interventional study of High Palmitic Acid Diet and Stearic Acid Test Meal in Healthy Middle-aged Subjects and Obesity & Overweight, sponsored by Florida State University. Not yet recruiting at 1 site in United States. Open to participants aged 40 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-11-04.
Sponsored by Florida State University · Not applicable, Interventional, and Basic science
The goal of this clinical trial is to evaluate the postprandial and long-term effects of dietary stearic acid on vascular function in overweight or obese adult males and females aged 40-70 years. The main questions it aims to answer are:
Participants will:
11,522 studies on the registry are indexed under Obesity; 2,033 are open to participants now.
This study's planned enrollment of 40 is below the median of 67 across 9,006 interventional studies indexed under Obesity.
Browse Obesity studies →Florida State University is the lead sponsor of 249 studies on the registry; 47 are open to participants now.
Of its 16 completed or terminated interventional studies of FDA-regulated products, 9 (56%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Other: High Palmitic Acid Diet · Other: Stearic Acid Test Meal · Other: High Stearic Acid Diet · Other: Palmitic Acid Test Meal
Other: High Palmitic Acid Diet · Other: Oleic Acid Test Meal · Other: High Oleic Acid Diet · Other: Palmitic Acid Test Meal
On this intervention, participants will be given a diet rich in palmitic acid (\~35% kcal/d palm stearin) for 14 days.
Participants will be given a test meal containing 50 g of stearic acid-rich (\~90/\~10% cocoa butter / high-linoleic sunflower oil) fat.
Participants will be given a test meal with 50 g of oleic acid-rich (\~55/\~45% palm olein / high-oleic sunflower oil) fat.
Participants will be given a high stearic acid-rich diet (\~35% kcal/d \~90/\~10% cocoa butter / high-linoleic sunflower oil mixture) for 14 days total.
Participants will be given a high oleic acid-rich (\~35% kcal/d \~55/\~45% palm olein / high-oleic sunflower oil mixture) for 14 days total.
Participants will be given a test meal containing 50 g of stearic acid-rich (50g palm oil) fat.
Postprandial Endothelial Function after a Stearic Acid vs Oleic Acid Test Meal
Brachial artery flow-mediated dilation (FMD) as measured in % dilation after a test meal
Time frame: Day 1 of the stearic acid and oleic acid diets, after consuming the stearic acid or oleic acid test meals, respectively
Fasting Long-Term Changes Endothelial Function
Brachial artery flow-mediated dilation (FMD) as measured in % dilation
Time frame: Fasting FMD measured on day 15 after the oleic acid and stearic acid diets
Postprandial Endothelial Function after Palmitic Acid Challenge Meal
Brachial artery flow-mediated dilation (FMD) as measured in % dilation
Time frame: Day 15 after the high oleic acid and stearic acid diets, following the palmitic acid test meal
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Dec 2026; primary completion for Aug 2027, 8 months later.
Of 3,680 non-industry interventional studies with no phase under Obesity, half reached primary completion within 23 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 43. This study's planned 8 months is below that.
Counting every sponsor, half of 3,843 studies reached it within 22 months; a quarter within 10 and three quarters within 42.
Start moved once since we started tracking on Sep 25, 2026: Oct 2026 → Dec 2026, on Nov 4, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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